cardiovascular prevention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

ACAT inhibition

pactimibe
CAPTIVATE, 2009      NCTpactimibeplaceboLow risk of bias -
ACTIVATE, 2006      NCTpactimibeplaceboLow risk of bias -

anticoagulant

not classified
MacMillan, 1960   anticoagulantno anticoagulant -
Borchegrevink, 1960   anticoagulantno anticoagulant -
Clausen, 1961   anticoagulantno anticoagulant -
Harvald, 1961   anticoagulantno anticoagulant -
Conrad, 1964     anticoagulantno anticoagulant -
Wasserman, 1966   anticoagulantno anticoagulant -
Loeliger, 1967   anticoagulantno anticoagulant -
Lovell, 1967   anticoagulantno anticoagulant -
Seaman, 1969     anticoagulantno anticoagulant -
Sorensen, 1969   anticoagulantno anticoagulant -
Meuwisse,, 1969   anticoagulantno anticoagulant -
Drapkin and Merskey, 1972     anticoagulantno anticoagulant -
Sixty Plus Reinfarction, 1980   coumarin congenersplaceboLow risk of bias -
ASPECT, 1994   nicoumalone or phenprocoumonplacebo -
Breddin, 1980   phenprocoumonplaceboLow risk of bias -
dicoumarol
Apenstrom and Korsan-Bengtsen, 1964   dicoumarolno anticoagulant -
rivaroxaban
COMPASS (rivaroxaban alone), 2017    NCTrivaroxabanaspirinsecondary prevention -
COMPASS (rivaroxaban + aspirin), 2017      NCTrivaroxaban + aspirinaspirinsecondary preventionLow risk of bias -
wafarin
WARIS, 1990   warfarinplaceboLow risk of bias -
warfarin
Thrombosis Prevention trial (Warfarin), 1998        NCTwarfarinplaceboprimary preventionLow risk of bias suggesting
Thrombosis Prevention trial (W plus A), 1998        NCTwarfarin + aspirinplaceboprimary preventionLow risk of bias suggesting

antioxydants

not classified
Tepel, 2003     acetylcysteineplaceboLow risk of bias suggesting
HPS antioxidant, 2002     combinationplaceboLow risk of bias negative
WAVE (Waters), 2002     combinationplaceboLow risk of bias negative
POPADAD (antioxydant), 2008   combinationplaceboLow risk of bias negative
PHS II beta carotene, 2003          NCTcombinationplaceboLow risk of bias -
SUVIMAX, 2005     combinationplaceboLow risk of bias negative
HATS, 2001     combinationplaceboLow risk of bias negative
MVP, 1997     combinationplaceboLow risk of bias negative
PHS II (multivitamin), 2012        NCTcombinationplaceboLow risk of bias negative
ARISE, 2008      NCTsuccinobucol placeboLow risk of bias suggesting
beta carotene
ATBC beta carotene, 1994     beta caroteneplaceboLow risk of bias -
CARET beta carotene, 1996       beta caroteneplaceboLow risk of bias negative
SCP beta carotene, 1990   beta caroteneplaceboLow risk of bias negative
NSCP (Green) beta carotene, 1999     beta caroteneplaceboLow risk of bias negative
PHS beta carotene, 1996     beta caroteneplaceboLow risk of bias suggesting
WHS beta carotene, 1999        NCTbeta caroteneplaceboLow risk of bias negative
WACS beta-caroten, 2007        NCTbeta caroteneplaceboLow risk of bias negative
ATBC 2nd prev subgroup (b carotene), 1998     beta caroteneplaceboLow risk of bias negative
vitamin c
WACS vitamin C, 2007        NCTvitamin CplaceboLow risk of bias negative
PHS II vitamin C, 2008    NCTvitamin CplaceboLow risk of bias negative
vitamin e
GISSI, 1999     vitamin EcontrolRisk of bias negative
PPP, 2001     vitamin EcontrolRisk of bias negative
ATBC vitamin E, 1994     vitamin EplaceboLow risk of bias suggesting
CHAOS, 1996   vitamin EplaceboLow risk of bias suggesting
HOPE, 2000     vitamin EplaceboLow risk of bias negative
AREDS, 2001     vitamin EplaceboLow risk of bias negative
Linxian, 1993     vitamin Eplacebonegative
WACS vitamin E, 2007        NCTvitamin EplaceboLow risk of bias negative
PHS II vitamin E, 2008    NCTvitamin EplaceboLow risk of bias negative
WHS vitamin E, 2005      NCTvitamin EplaceboLow risk of bias negative
ASAP, 2000         vitamin EplaceboLow risk of bias negative
SPACE, 2000     vitamin EplaceboLow risk of bias suggesting
HOPE renal insufficiency subgroup, 2004     vitamin EplaceboLow risk of bias negative
ATBC 2nd prev subgroup (vitamin E), 1998       vitamin EplaceboLow risk of bias negative

antiplatelets drug

aspirin
JPAD, 2008      NCTaspirinno treatmentRisk of bias suggesting
PPP (diabetics sub group), 2003   aspirinno treatmentExploratory negative
British Doctor’s Trial, 1988   aspirinno treatmentprimary preventionRisk of bias negative
Primary Prevention Project, 2001     aspirinno treatmentprimary preventionRisk of bias negative
POPADAD aspirin, 2008     aspirinplaceboLow risk of bias negative
DAMAD, 1989   aspirinplaceboLow risk of bias negative
ETDRS, 1992   aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989   aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005   aspirinplaceboLow risk of bias suggesting
Physicians Health Study, 1989    NCTaspirinplaceboprimary preventionLow risk of bias suggesting
Thrombosis Prevention Trial, 1998        NCTaspirinplaceboprimary preventionLow risk of bias suggesting
HOT, 1998     aspirinplaceboprimary preventionLow risk of bias suggesting
Women’s Health Study, 2005       aspirinplaceboprimary preventionLow risk of bias suggesting
AAA, 2009     aspirinplacebosecondary preventionLow risk of bias negative
Schoop, 1983   aspirinplaceboLow risk of bias -
Hess, 1985   aspirinplacebo -
Munich A, 1975   aspirinplaceboLow risk of bias -
Munich B, 1975   aspirinplaceboLow risk of bias -
CLIPS, 2007     aspirinplaceboLow risk of bias suggesting
CDPA, 1976   aspirinplaceboLow risk of bias negative
Cardiff I, 1974   aspirinplaceboLow risk of bias negative
Cardiff II, 1979   aspirinplaceboLow risk of bias negative
Vogel, 1979   aspirinplaceboLow risk of bias suggesting
AMIS, 1980    NCTaspirinplaceboLow risk of bias suggesting
GAMIS, 1980   aspirinplaceboLow risk of bias negative
PARIS, 1980   aspirinplaceboLow risk of bias negative
JAMIS, 1999     aspirinplacebosuggesting
SAPAT, 1992   aspirinplaceboLow risk of bias suggesting
clopidogrel
CAPRIE, 1996   clopidogrelaspirinsecondary preventionLow risk of bias suggesting
CAPRIE (PAD subgroup), 1996   clopidogrelaspirinLow risk of bias suggesting
ASCET    NCTclopidogrelaspirinRisk of bias negative
CHARISMA, 2006      NCTclopidogrelplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
dipyridamol
Atlanta (Sbar), 1967   dipyridamolcontrolLow risk of bias negative
Becker, 1967   dipyridamolcontrolLow risk of bias negative
Wirecki, 1967   dipyridamolcontrolLow risk of bias negative
Hess (2), 1985   aspirin + dipyridamolplaceboLow risk of bias -
Schoop (2), 1983   aspirin + dipyridamolplaceboLow risk of bias -
VA study, 1986   aspirin + dipyridamolplaceboLow risk of bias -
Igloe, 1970   dipyridamolplaceboLow risk of bias -
Zion, 1961   dipyridamolplaceboLow risk of bias -
Kinsella, 1962   dipyridamolplaceboLow risk of bias -
Leiberman, 1964   dipyridamolplaceboLow risk of bias -
Dewar, 1961   dipyridamolplaceboLow risk of bias -
Neumann, 1964   dipyridamolplaceboLow risk of bias -
Foulds, 1960   dipyridamolplaceboLow risk of bias -
PARIS, 1980   dipyridamol + aspirinplaceboLow risk of bias negative
PARIS-II, 1986   dipyridamol + aspirinplaceboLow risk of bias negative
PARIS, 1980   dipyridamol + aspirinaspirinLow risk of bias negative
ketanserine
PACK, 1996   ketanserineplaceboLow risk of bias -
Walden, 1991   ketanserineplaceboLow risk of bias -
Thulesius, 1987   ketanserineplaceboLow risk of bias -
picotamide
Cocozza, 1995     picotamideplaceboLow risk of bias negative
ADEP, 1993   picotamideplaceboLow risk of bias -
Neirotti, 1994   picotamideplaceboLow risk of bias -
Coto, 1989   picotamideplaceboLow risk of bias -
sulfinpyrazone
Dutch, 1980   sulfinyrazoneplacebonegative
suloctidil
Adriaensen, 1976   suloctidilplaceboLow risk of bias -
Verhaeghe, 1981   suloctidilplaceboLow risk of bias -
Jones, 1982   suloctidilplaceboLow risk of bias -
Holm, 1984   suloctidilplaceboLow risk of bias -
ticagrelor
EUCLID, 2016        NCTticagrelorclopidogrelLow risk of bias -
PEGASUS 60mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
PEGASUS 90mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
ticlopidine
Birmingham-A, 1979   ticlopidineplacebonegative
London diabetes, 1983   ticlopidineplacebonegative
TIMAD, 1984   ticlopidineplacebonegative
BTRS, 1992   ticlopidineplaceboLow risk of bias negative
Nyberg, 1984   ticlopidineplaceboLow risk of bias negative
EMATAP, 1993   ticlopidineplaceboLow risk of bias -
Katsumara, 1982   ticlopidineplaceboLow risk of bias -
Aukland, 1982   ticlopidineplaceboLow risk of bias -
Stiegler, 1984   ticlopidineplaceboLow risk of bias -
Ellis, 1986   ticlopidineplaceboLow risk of bias -
Cloarec, 1986   ticlopidineplaceboLow risk of bias -
Arcan, 1988   ticlopidineplaceboLow risk of bias -
Balsano, 1989   ticlopidineplaceboLow risk of bias -
STIMS, 1990   ticlopidineplaceboLow risk of bias -
Hurlow, 1980   ticlopidineplaceboLow risk of bias -
Krause, 1980   ticlopidineplaceboLow risk of bias -
Berglund, 1985   ticlopidineplaceboLow risk of bias negative
various
CRAMPS, 2000   cloricromeneplaceboLow risk of bias -
vorapaxar
TRA-2P TIMI 50, 2012        NCTvorapaxarplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
TRA-2P TIMI 50 (no prior stroke sub group), 2012     vorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting
TRA-2P TIMI 50 (MI subgroup), 2012        NCTvorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting

CEPT inhibition

not classified
REVEAL HPS-3 TIMI-55, 2017    NCTanacetrapibplaceboLow risk of bias remark
dal-VESSEL, 2011   dalcetrapibplaceboExploratory -
dal-OUTCOMES, 2012      NCTdalcetrapibplaceboLow risk of bias negative
ACCELERATE, 2017      NCTevacetrapibplaceboLow risk of bias suggesting
anacetrapib
DEFINE, 2010    NCTanacetrapibplaceboExploratory negative
REALIZE, 2015      NCTanacetrapibplaceboLow risk of bias negative
torcetrapib
RADIANCE 1, 2007      NCTtorcetrapibplaceboExploratory negative
ILLUMINATE, 2007      NCTtorcetrapibplaceboLow risk of bias negative
RADIANCE 2, 2007     torcetrapibplaceboLow risk of bias -
ILLUSTRATE, 2007      NCTtorcetrapibplaceboExploratory negative

cholesterol lowering intervention

not classified
FACS, 2010     acute coronary syndrome early initiation -
Shalnev VI, 2007   acute coronary syndrome early initiation -
FATS, 1990    NCTintensive lipid-lowering therapydietprimary preventionExploratory negative
Sakamoto, 2006     any statinno statinacute coronary syndrome early initiation Risk of bias -