cardiovascular prevention  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

ACAT inhibition

pactimibe
CAPTIVATE, 2009pactimibeplaceboNCT00151788Low risk of bias -
ACTIVATE, 2006pactimibeplaceboNCT00185042Low risk of bias -

anticoagulant

not classified
MacMillan, 1960anticoagulantno anticoagulant -
Borchegrevink, 1960anticoagulantno anticoagulant -
Clausen, 1961anticoagulantno anticoagulant -
Harvald, 1961anticoagulantno anticoagulant -
Conrad, 1964anticoagulantno anticoagulant -
Wasserman, 1966anticoagulantno anticoagulant -
Loeliger, 1967anticoagulantno anticoagulant -
Lovell, 1967anticoagulantno anticoagulant -
Seaman, 1969anticoagulantno anticoagulant -
Sorensen, 1969anticoagulantno anticoagulant -
Meuwisse,, 1969anticoagulantno anticoagulant -
Drapkin and Merskey, 1972anticoagulantno anticoagulant -
Sixty Plus Reinfarction, 1980coumarin congenersplaceboLow risk of bias -
ASPECT, 1994nicoumalone or phenprocoumonplacebo -
Breddin, 1980phenprocoumonplaceboLow risk of bias -
dicoumarol
Apenstrom and Korsan-Bengtsen, 1964dicoumarolno anticoagulant -
rivaroxaban
COMPASS (rivaroxaban alone), 2017rivaroxabanaspirinsecondary preventionNCT01776424 -
COMPASS (rivaroxaban + aspirin), 2017rivaroxaban + aspirinaspirinsecondary preventionNCT01776424Low risk of bias -
COMMANDER HF ongoing rivaroxabanplaceboNCT01877915 ongoing
wafarin
WARIS, 1990warfarinplaceboLow risk of bias -
warfarin
Thrombosis Prevention trial (Warfarin), 1998warfarinplaceboprimary preventionNCT00000614Low risk of bias suggesting
Thrombosis Prevention trial (W plus A), 1998warfarin + aspirinplaceboprimary preventionNCT00000614Low risk of bias suggesting

antioxydants

not classified
Tepel, 2003acetylcysteineplaceboLow risk of bias suggesting
HPS antioxidant, 2002combinationplaceboLow risk of bias negative
WAVE (Waters), 2002combinationplaceboLow risk of bias negative
POPADAD (antioxydant), 2008combinationplaceboISRCTN53295293Low risk of bias negative
PHS II beta carotene, 2003combinationplaceboNCT00270647Low risk of bias -
SUVIMAX, 2005combinationplaceboLow risk of bias negative
HATS, 2001combinationplaceboLow risk of bias negative
MVP, 1997combinationplaceboLow risk of bias negative
PHS II (multivitamin), 2012combinationplaceboNCT00270647Low risk of bias negative
ARISE, 2008succinobucol placeboNCT00066898Low risk of bias suggesting
beta carotene
ATBC beta carotene, 1994beta caroteneplaceboLow risk of bias -
CARET beta carotene, 1996beta caroteneplaceboLow risk of bias negative
SCP beta carotene, 1990beta caroteneplaceboLow risk of bias negative
NSCP (Green) beta carotene, 1999beta caroteneplaceboLow risk of bias negative
PHS beta carotene, 1996beta caroteneplaceboLow risk of bias suggesting
WHS beta carotene, 1999beta caroteneplaceboNCT00000479Low risk of bias negative
WACS beta-caroten, 2007beta caroteneplaceboNCT00000541Low risk of bias negative
ATBC 2nd prev subgroup (b carotene), 1998beta caroteneplaceboLow risk of bias negative
vitamin c
WACS vitamin C, 2007vitamin CplaceboNCT00000541Low risk of bias negative
PHS II vitamin C, 2008vitamin CplaceboNCT00270647Low risk of bias negative
vitamin e
GISSI, 1999vitamin EcontrolRisk of bias negative
PPP, 2001vitamin EcontrolRisk of bias negative
ATBC vitamin E, 1994vitamin EplaceboLow risk of bias suggesting
CHAOS, 1996vitamin EplaceboLow risk of bias suggesting
HOPE, 2000vitamin EplaceboLow risk of bias negative
AREDS, 2001vitamin EplaceboLow risk of bias negative
Linxian, 1993vitamin Eplacebonegative
WACS vitamin E, 2007vitamin EplaceboNCT00000541Low risk of bias negative
PHS II vitamin E, 2008vitamin EplaceboNCT00270647Low risk of bias negative
WHS vitamin E, 2005vitamin EplaceboNCT00000479Low risk of bias negative
ASAP, 2000vitamin EplaceboLow risk of bias negative
SPACE, 2000vitamin EplaceboLow risk of bias suggesting
HOPE renal insufficiency subgroup, 2004vitamin EplaceboLow risk of bias negative
ATBC 2nd prev subgroup (vitamin E), 1998vitamin EplaceboLow risk of bias negative

antiplatelets drug

not classified
Brittenden J ongoing ongoing
Brittenden J (2) ongoing ongoing
Fowkes FGR ongoing ongoing
McCollum CN ongoing ongoing
aspirin
JPPP ongoing aspirinno aspirinprimary preventionNCT00225849Risk of bias ongoing
JPAD, 2008aspirinno treatmentNCT00110448Risk of bias suggesting
PPP (diabetics sub group), 2003aspirinno treatmentExploratory negative
British Doctor’s Trial, 1988aspirinno treatmentprimary preventionRisk of bias negative
Primary Prevention Project, 2001aspirinno treatmentprimary preventionRisk of bias negative
POPADAD aspirin, 2008aspirinplaceboISRCTN53295293Low risk of bias negative
DAMAD, 1989aspirinplaceboLow risk of bias negative
ETDRS, 1992aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005aspirinplaceboLow risk of bias suggesting
Physicians Health Study, 1989aspirinplaceboprimary preventionNCT00000500Low risk of bias suggesting
Thrombosis Prevention Trial, 1998aspirinplaceboprimary preventionNCT00000614Low risk of bias suggesting
HOT, 1998aspirinplaceboprimary preventionLow risk of bias suggesting
Women’s Health Study, 2005aspirinplaceboprimary preventionLow risk of bias suggesting
AAA, 2009aspirinplacebosecondary preventionISRCTN66587262Low risk of bias negative
Schoop, 1983aspirinplaceboLow risk of bias -
Hess, 1985aspirinplacebo -
Munich A, 1975aspirinplaceboLow risk of bias -
Munich B, 1975aspirinplaceboLow risk of bias -
CLIPS, 2007aspirinplaceboLow risk of bias suggesting
CDPA, 1976aspirinplaceboLow risk of bias negative
Cardiff I, 1974aspirinplaceboLow risk of bias negative
Cardiff II, 1979aspirinplaceboLow risk of bias negative
Vogel, 1979aspirinplaceboLow risk of bias suggesting
AMIS, 1980aspirinplaceboNCT00000491Low risk of bias suggesting
GAMIS, 1980aspirinplaceboLow risk of bias negative
PARIS, 1980aspirinplaceboLow risk of bias negative
JAMIS, 1999aspirinplacebosuggesting
SAPAT, 1992aspirinplaceboLow risk of bias suggesting
ASCEND (aspirin) ongoing aspirinplaceboNCT00135226Low risk of bias ongoing
ACCEPT-D ongoing aspirinplaceboISRCTN48110081Risk of bias ongoing
clopidogrel
CAPRIE, 1996clopidogrelaspirinsecondary preventionLow risk of bias suggesting
CAPRIE (PAD subgroup), 1996clopidogrelaspirinLow risk of bias suggesting
ASCETclopidogrelaspirinNCT00222261Risk of bias negative
CHARISMA, 2006clopidogrelplacebo (on top aspirin)secondary preventionNCT00050817Low risk of bias suggesting
dipyridamol
Atlanta (Sbar), 1967dipyridamolcontrolLow risk of bias negative
Becker, 1967dipyridamolcontrolLow risk of bias negative
Wirecki, 1967dipyridamolcontrolLow risk of bias negative
Hess (2), 1985aspirin + dipyridamolplaceboLow risk of bias -
Schoop (2), 1983aspirin + dipyridamolplaceboLow risk of bias -
VA study, 1986aspirin + dipyridamolplaceboLow risk of bias -
Igloe, 1970dipyridamolplaceboLow risk of bias -
Zion, 1961dipyridamolplaceboLow risk of bias -
Kinsella, 1962dipyridamolplaceboLow risk of bias -
Leiberman, 1964dipyridamolplaceboLow risk of bias -
Dewar, 1961dipyridamolplaceboLow risk of bias -
Neumann, 1964dipyridamolplaceboLow risk of bias -
Foulds, 1960dipyridamolplaceboLow risk of bias -
PARIS, 1980dipyridamol + aspirinplaceboLow risk of bias negative
PARIS-II, 1986dipyridamol + aspirinplaceboLow risk of bias negative
PARIS, 1980dipyridamol + aspirinaspirinLow risk of bias negative
ketanserine
PACK, 1996ketanserineplaceboLow risk of bias -
Walden, 1991ketanserineplaceboLow risk of bias -
Thulesius, 1987ketanserineplaceboLow risk of bias -
picotamide
Cocozza, 1995picotamideplaceboLow risk of bias negative
ADEP, 1993picotamideplaceboLow risk of bias -
Neirotti, 1994picotamideplaceboLow risk of bias -
Coto, 1989picotamideplaceboLow risk of bias -
sulfinpyrazone
Dutch, 1980sulfinyrazoneplacebonegative
suloctidil
Adriaensen, 1976suloctidilplaceboLow risk of bias -
Verhaeghe, 1981suloctidilplaceboLow risk of bias -
Jones, 1982suloctidilplaceboLow risk of bias -
Holm, 1984suloctidilplaceboLow risk of bias -
ticagrelor
EUCLID, 2016ticagrelorclopidogrelNCT01732822Low risk of bias -
PEGASUS 60mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
PEGASUS 90mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
ticlopidine
Birmingham-A, 1979ticlopidineplacebonegative
London diabetes, 1983ticlopidineplacebonegative
TIMAD, 1984ticlopidineplacebonegative
BTRS, 1992ticlopidineplaceboLow risk of bias negative
Nyberg, 1984ticlopidineplaceboLow risk of bias negative
EMATAP, 1993ticlopidineplaceboLow risk of bias -
Katsumara, 1982ticlopidineplaceboLow risk of bias -
Aukland, 1982ticlopidineplaceboLow risk of bias -
Stiegler, 1984ticlopidineplaceboLow risk of bias -
Ellis, 1986ticlopidineplaceboLow risk of bias -
Cloarec, 1986ticlopidineplaceboLow risk of bias -
Arcan, 1988ticlopidineplaceboLow risk of bias -
Balsano, 1989ticlopidineplaceboLow risk of bias -
STIMS, 1990ticlopidineplaceboLow risk of bias -
Hurlow, 1980ticlopidineplaceboLow risk of bias -
Krause, 1980ticlopidineplaceboLow risk of bias -
Berglund, 1985ticlopidineplaceboLow risk of bias negative
various
CRAMPS, 2000cloricromeneplaceboLow risk of bias -
vorapaxar
TRA-2P TIMI 50, 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Low risk of bias suggesting
TRA-2P TIMI 50 (no prior stroke sub group), 2012vorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting
TRA-2P TIMI 50 (MI subgroup), 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Exploratory suggesting

CEPT inhibition

not classified
NCT01516541 ongoing dalcetrapibNCT01516541 ongoing
NCT01059682 ongoing dalcetrapibNCT01059682 ongoing
REVEAL HPS-3 TIMI-55, 2017anacetrapibplaceboNCT01252953Low risk of bias -
dal-VESSEL, 2011dalcetrapibplaceboExploratory -
dal-OUTCOMES, 2012dalcetrapibplaceboNCT00658515Low risk of bias negative
ACCELERATE, 2017evacetrapibplaceboNCT01687998Low risk of bias suggesting
anacetrapib
DEFINE, 2010anacetrapibplaceboNCT00685776Exploratory negative
REALIZE, 2015anacetrapibplaceboNCT01524289Low risk of bias negative
torcetrapib
RADIANCE 1, 2007torcetrapibplaceboNCT00136981Exploratory negative
ILLUMINATE, 2007torcetrapibplaceboNCT00134264Low risk of bias negative
RADIANCE 2, 2007torcetrapibplaceboLow risk of bias -
ILLUSTRATE, 2007torcetrapibplaceboNCT00134173Exploratory negative

cholesterol lowering intervention

not classified
FACS, 2010acute coronary syndrome early initiation -
Shalnev VI, 2007acute coronary syndrome early initiation -
Amburgey CF ongoing Peripheral Arterial Disease ongoing
FATS, 1990intensive lipid-lowering therapydietprimary preventionNCT00000512Exploratory negative
Sakamoto, 2006any statinno statinacute coronary syndrome early initiation Risk of bias -
POSCH, 1990partial ileum bypass surgeryno surgeryNCT00000490Risk of bias negative
SOLID-TIMI 52darapladibplaceboacute coronary syndrome early initiation NCT01000727 -
Ren, 2009simvastatinplaceboacute coronary syndrome early initiation Low risk of bias -
HARP, 1994various drugsplaceboNCT00000461Exploratory negative
OACIS-LIPID, 2008pravastatinusual careacute coronary syndrome early initiation Low risk of bias -
SCRIP, 1994various drugsusual careNCT00000508Exploratory negative
JAPAN ACS, 2009pitavastatinatorvastatinacute coronary syndrome early initiation NCT00242944Exploratory -
Post CABG (diabetic sub group), 1999aggressive cholesterol-loweringmoderate cholesterol-loweringdiabetic patients type 2 diabetes Low risk of bias -
atorvastatin
ASCOT (diabetics sub group), 2003atorvastatinplacebodiabetic patients type 2 diabetes Exploratory negative
CARDS, 2004atorvastatinplacebodiabetic type 2 diabetes NCT00327418Low risk of bias conclusive
Deutsche Diabetes Dialyse Studie (4D), 2005atorvastatinplaceboLow risk of bias suggesting
ASPEN, 2006atorvastatinplacebodiabetic type 2 diabetes Low risk of bias negative
ASPEN, 2006atorvastatinplacebodiabetic patients trastuzumab-naif type 2 diabetes Low risk of bias negative
ASCOT, 2003atorvastatinplaceboat risk hypertensive hypertensive patients Low risk of bias conclusive
MIRACL, 2001atorvastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
macin, 2005atorvastatinplaceboacute coronary syndrome squamous NSCLC Low risk of bias -
SALTIRE, 2005atorvastatinplaceboaortic stenosisLow risk of bias negative
Mohler III, 2003atorvastatinplaceboPeripheral Arterial DiseaseExploratory -
SPARCL, 2006atorvastatinplacebopost stroke cerebral vascular disease NCT00147602Low risk of bias suggesting
Strey, 2005atorvastatinplaceboheart failure -
Mohler, 2003atorvastatinplacebosecondary preventionLow risk of bias -
ASPEN (primary prevention sub group), 2006atorvastatinplacebodiabetic type 2 diabetes Low risk of bias negative
ASCOT (women subgroup) , 2003AtorvastatinplacebowomenExploratory negative
Colivicchi, 2002atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
GREACE, 2002atorvastatinusual caresecondary preventionRisk of bias suggesting
AVERT, 1999atorvastatin high doseangioplastysecondary preventionRisk of bias negative
TNT (diabetic sub group), 2006atorvastatin high doseatorvastatindiabetic patients type 2 diabetes Low risk of bias suggesting
TNT, 2005atorvastatin high doseatorvastatinsecondary preventionNCT00327691Low risk of bias conclusive
Vascular basis, 2005atorvastatin high doselovastatinsecondary preventionExploratory negative
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndrome early initiation Low risk of bias suggesting
REVERSAL, 2004atorvastatin high dosepravastatinsecondary preventionExploratory negative
PROVE-IT, 2004atorvastatin high dosepravastatindiabetic early initiation Low risk of bias suggesting
SAGE, 2007atorvastatin high dosepravastatinsecondary preventionExploratory