stable angina

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anti-anginal drugs

ranolazine
MARIZA, 2004ranolazine 1000mgplacebo -
RAN080, 2005ranolazine 1000mgplacebo -
CARISA 1000mg, 2004ranolazine 1000mgplacebo (on top standard treatment)negative
ERICA, 2006ranolazine 1000mg + amlodipineplacebo + amlodipineNCT00091429Low risk of bias -

antibiotics

not classified
PROVE-IT, 2005Gatifloxacinplacebonegative
ROXIS, 1999Roxithromycinplacebonegative
Leowattana et al, 2001Roxithromycinplacebonegative
ANTIBIO, 2003Roxithromycinplacebonegative
Azithromycin
Gupta et al, 1997Azithromycinplacebonegative
ACADEMIC, 1999Azithromycinplacebonegative
WIZARD, 2003Azithromycinplacebonegative
ACES, 2005AzithromycinplaceboNCT00000617negative
STAMINA (Azithromycin), 2002AzithromycinplaceboLow risk of bias negative
AZACS, 2003Azithromycinplacebonegative
clarithromycin
CLARIFY, 2001clarithromycinplacebosuggesting
CLARICOR, 2006clarithromycinplaceboNCT00121550Low risk of bias negative

antithrombotics

not classified
Murphy, 2003roxifiban placeboExploratory -
aspirin
SAPAT, 1992aspirinplaceboLow risk of bias suggesting
clopidogrel
ASCETclopidogrelaspirinNCT00222261Risk of bias negative
dipyridamol
Atlanta (Sbar), 1967dipyridamolcontrolExploratory negative
Becker, 1967dipyridamolcontrolExploratory negative
Wirecki, 1967dipyridamolcontrolExploratory negative
Igloe, 1970dipyridamolplaceboExploratory -
Zion, 1961dipyridamolplaceboExploratory -
Kinsella, 1962dipyridamolplaceboExploratory -
Leiberman, 1964dipyridamolplaceboExploratory -
Dewar, 1961dipyridamolplaceboExploratory -
Neumann, 1964dipyridamolplaceboExploratory -
Foulds, 1960dipyridamolplaceboExploratory -
ticlopidine
Berglund, 1985ticlopidineplaceboExploratory negative

HR-slowing agents

ivabradine
Borer (CL2-009) 10mg, 2003ivabradine 10mgplacebo -
BEAUTIFUL, 2008ivabradine 15mgplaceboNCT00143507Low risk of bias negative
Borer (CL2-009) 20mg, 2003ivabradine 20mgplacebo -
SIGNIFY, 2014ivabradine 20mgplaceboISRCTN61576291negative
Borer (CL2-009) 5mg, 2003ivabradine 5mgplacebo -
BEAUTIFUL (angina subgroup)ivabradine 15mgplacebo (on top standard treatment)Exploratory suggesting
CL3-018 10mgivabradine 10mgplacebo on top of amlodipine -
CL3-018 15mgivabradine 15mgplacebo on top of amlodipine -
ASSOCIATE (Tardif), 2009ivabradine 15mgplacebo on top of atenololNCT00202566Low risk of bias -
CL3-023 (15mg)ivabradineamlodipineLow risk of bias -
CL3-023 (20mg)ivabradineamlodipineLow risk of bias -
Ruzyllo (CL3-023) 15mg, 2007ivabradine 15mgamlodipineLow risk of bias -
Ruzyllo (CL3-023) 20mg, 2007ivabradine 20mgamlodipineLow risk of bias -
INITIATIVE (CL3-017, Tardif) 15mg, 2005ivabradine 15mgatenolol -
INITIATIVE (CL3-017, Tardif) 20mg, 2005ivabradine 20mgatenololLow risk of bias -

myocardial revascularization

not classified
Nordic Bifurcation Study ongoing ABNCT00376571 ongoing
Serruys Benestent 2, 1998stentballoon angioplastysuggesting
Versaci , 1997stentballoon angioplastysuggesting
Fischman STRESS, 1994stentballoon angioplastysuggesting
Serruys Benestent, 1994stentballoon angioplastysuggesting
Moer, 2001stentballoon angioplastynegative
Doucet, 2001stentballoon angioplastynegative
Koning, 2001stentballoon angioplastysuggesting
Park, 2000stentballoon angioplastynegative
Lotan, 2000stentballoon angioplastysuggesting
Weaver, 2000stentballoon angioplastysuggesting
Dangas, 2000stentballoon angioplastynegative
Fluck, 2000stentballoon angioplastynegative
Lafont, 2000stentballoon angioplastynegative
Witkowski, 2000stentballoon angioplastynegative
Kastrati, 2000stentballoon angioplastynegative
Di Marlo, 2000stentballoon angioplastynegative
Serruys, 2000stentballoon angioplastynegative
Lincoff (EPISTENT), 1999stentballoon angioplastyNCT00271401suggesting
Buller, 1999stentballoon angioplastysuggesting
Betriu, 1999stentballoon angioplastysuggesting
Hoher, 1999stentballoon angioplastysuggesting
Sievert, 1999stentballoon angioplastysuggesting
Eeckout, 1996stentballoon angioplastynegative
Sirnes, 1996stentballoon angioplastysuggesting
Savage, 1998stentballoon angioplastynegative
Erbel, 1998stentballoon angioplastysuggesting
Rubartelli, 1998stentballoon angioplastysuggesting
Hancock, 1998stentballoon angioplastysuggesting
Rodriguez, 1998stentballoon angioplastynegative
FEMH-93005 ongoing dexamethasone eluting stentbare-metal stentNCT00190099 ongoing
Nordic Bifurcation Stent Technique Study ongoing crush stentingculotte stentingNCT00292305 ongoing
EVOLVE, 2012bioabsorbable polymer EESeverolimus eluting stentNCT01135225 -
ISCHEMIA ongoing PCI with or without stentmedical treatmentRisk of bias ongoing
FAME II, 2012FFR-guided PCIno PCINCT01132495suggesting
Leon (high dose), 2005TMRplaceboLow risk of bias negative
SYNTAX (diabetic), 2010PCI with drug-eluting stentsCABGNCT00114972Exploratory -
ARTS, 2001stentCABGnegative
ERACI II, 2003stentCABGRisk of bias suggesting
SOS, 2002stentCABGNCT00475449Risk of bias suggesting
CARDia (PCI), 2008stentCABGISRCTN19872154Risk of bias negative
LEMANS, 2002stentCABGNCT00375063Exploratory negative
MASS II, 2007stentCABGRisk of bias negative
Myoprotect, 2004stentCABGExploratory -
CisowskistentE-ACABnegative
STICH (vs med), 2011CABGmedical treatmentNCT00023595Risk of bias suggesting
CASS subgroup, 1985CABGmedical treatmentExploratory suggesting
Schofield, 1999TMRmedical treatmentRisk of bias negative
Allen, 1999TMRmedical treatmentRisk of bias negative
Frazier, 1999TMRmedical treatmentRisk of bias negative
ATLANTIC (Burkhoff), 1999TMRmedical treatmentRisk of bias negative
Aaberge, 2000TMRmedical treatmentRisk of bias negative
Huikeshoven, 2003TMRmedical treatmentExploratory -
PACIFIC, 2000TMRmedical treatmentRisk of bias negative
Stone, 2002TMRmedical treatmentRisk of bias negative
Salem, 2004TMRmedical treatmentLow risk of bias negative
van der Sloot, 2004TMRmedical treatmentExploratory negative
March, 1999TMRmedical treatmentExploratory -
Gray, 2003TMRmedical treatmentExploratory negative
Diegeler, 2002stentMIDCABRisk of bias negative
Drenth, 2002stentMIDCABRisk of bias negative
Grip, 2001stentMIDCABnegative
SIMA, 2000stentMIDCABnegative
Kim, 2005stentMIDCABRisk of bias -
OCTOSTENT, 2003stentOPCABNCT00975858Risk of bias negative
Costar II, 2008CoStar stentpaclitaxel eluting stentNCT00165035Risk of bias negative
GENESIS Trial CP-01 ongoing pimecrolimus eluting stentpimecrolimus paclitaxelNCT00322569 ongoing
ISAR-TEST-4 (biodegradable polymer), 2009sirolimus biodegradable polymersirolimus eluting stentNCT00598676).Risk of bias negative
Galiñanes, 2004TMRthoracic sympathectomyExploratory negative
angioplasty
AMIST (Reeves), 2004angioplastyMIDCABRisk of bias -
biolimus eluting stent
LEADERS, 2008biolimus eluting stentsirolimus eluting stentNCT00389220negative
Coronary Artery Bypass Surgery
Allen, 2000TMR+CABGCABG -
STICH (ventricular reconstruction), 2009CABG+surgical ventricular reconstructionCABGNCT00023595negative
Loubani, 2003TMR+CABGCABGExploratory -
Zhao, 2006TMR+CABGCABGExploratory -
MASS II, 2007CABGmedical treatmentnegative
VA, 1984CABGmedical treatmentsuggesting
ECSS (European), 1988CABGmedical treatmentsuggesting
CASS, 1983CABGmedical treatmentNCT00000489negative
Texas, 1977CABGmedical treatmentnegative
Oregon, 1979CABGmedical treatmentnegative
New zealand 1, 1981CABGmedical treatmentnegative
BARI 2D, 2009CABG or PCImedical treatmentNCT00006305Risk of bias negative
dactinomycin eluting stent
ACTION, 2004dactinomycin eluting stentbare-metal stentsuggesting
drug-eluting stents
ISAR-CABG ongoing drug-eluting stentsbare-metal stentNCT00611910 ongoing
Boudriot, 2008DESCABGExploratory negative
Leipzig ongoing drug-eluting stentsCABGNCT00176397 ongoing
FREEDOM, 2012PCI with drug-eluting stentsCABGNCT00086450Risk of bias negative
Hong, 2005PCI withdrug-eluting stentsCABGRisk of bias -
VA CARDS ongoing PCI withdrug-eluting stentsCABGNCT00326196Risk of bias ongoing
everolimus eluting stent
FUTURE I, 2004everolimus eluting stentbare-metal stentnegative
FUTURE II, 2006everolimus eluting stentbare-metal stent -
SPIRIT I, 2005everolimus eluting stentbare-metal stentNCT00180453Exploratory negative
SPIRIT II, 2006everolimus eluting stentpaclitaxel eluting stentNCT00180310Risk of bias negative
SPIRIT IV, 2010everolimus eluting stentpaclitaxel eluting stentNCT00307047Risk of bias suggesting
SPIRIT III, 2008everolimus eluting stentpaclitaxel eluting stentNCT00180479Exploratory suggesting
COMPARE, 2009everolimus eluting stentpaclitaxel eluting stentNCT01016041Risk of bias suggesting
SORT OUT IV, 2012everolimus eluting stentsirolimus eluting stentNCT00552877Risk of bias -
ISAR-TEST 4 (EES vs SES)everolimus eluting stentsirolimus eluting stentsuggesting
LEFT-MAIN-2 ongoing everolimus eluting stentzotarolimus eluting stentNCT00598637 ongoing
paclitaxel
TAXUS I, 2003paclitaxel eluting stentbare-metal stentnegative
TAXUS II, 2003paclitaxel eluting stentbare-metal stentNCT00299026suggesting
TAXUS IV, 2004paclitaxel eluting stentbare-metal stentNCT00292474Low risk of bias suggesting
SCORE, 2004paclitaxel eluting stentbare-metal stentsuggesting
TAXUS V (all patients), 2005paclitaxel eluting stentbare-metal stentNCT00301522suggesting
TAXUS VI, 2005paclitaxel eluting stentbare-metal stentNCT00297804suggesting
BASKET-SAVAGE ongoing paclitaxel eluting stentbare-metal stentNCT00595647 ongoing
ASPECT, 2003paclitaxel, non-polymeric eluting stentbare-metal stentNCT00196079suggesting
ELUTES, 2004paclitaxel, non-polymeric eluting stentbare-metal stentnegative
DELIVER, 2004paclitaxel, non-polymeric eluting stentbare-metal stentRisk of bias negative
PATENCY, 2002paclitaxel, non-polymeric eluting stentbare-metal stentnegative
SYNTAX, 2009paclitaxel eluting stentCABGNCT00114972Risk of bias suggesting
VELETI ongoing paclitaxel eluting stentmedical treatmentNCT00289835 ongoing
PEPCAD IV ongoing paclitaxel eluting balloonpaclitaxel eluting stentNCT00462631 ongoing
PERSEUS Workhorse, 2010 ongoing paclitaxel eluting stentpaclitaxel eluting stentNCT00484315 ongoing
FRE-RACE ongoing paclitaxel eluting stentsirolimus eluting stentNCT00130546 ongoing
PCI
AVERT, 1995PCI with or without stentmedical treatmentRisk of bias negative
COURAGE, 2007PCI with or without stentmedical treatmentNCT00007657Risk of bias suggesting
MASS II, 2007PCI with or without stentmedical treatmentRisk of bias negative
Dakik, 1998PCI with or without stentmedical treatmentRisk of bias negative
ALKK, 2003PCI with or without stentmedical treatmentRisk of bias suggesting
Hambrecht, 2004PCI with or without stentmedical treatmentRisk of bias negative
Bech, 2001PCI with or without stentmedical treatmentRisk of bias negative
TIME, 2001PCI with or without stentmedical treatmentRisk of bias -
FAME, 2008FFR-guided PCIno PCINCT00267774suggesting
DEFER, 2001FFR-guided PCIno PCInegative
AWESOME, 2001PCICABGRisk of bias -
PTCA
RITA 2, 1997balloon angioplastymedical treatmentRisk of bias suggesting
ACME, 1992balloon angioplastymedical treatmentRisk of bias suggesting
Sievers, 1993balloon angioplastymedical treatmentRisk of bias negative
MASS, 1995balloon angioplastymedical treatmentRisk of bias suggesting
ACME 2 (Folland), 1997balloon angioplastymedical treatmentRisk of bias negative
ACIP, 1997balloon angioplastymedical treatmentExploratory negative
INSPIRE, 2006balloon angioplastymedical treatmentRisk of bias negative
SWISSI II, 2007balloon angioplastymedical treatmentNCT00387231Exploratory suggesting
BARI, 1996balloon angioplastyCABGNCT00000462negative
MASS, 1995balloon angioplastyCABGnegative
CABRI, 1995balloon angioplastyCABGnegative
EAST, 1994balloon angioplastyCABGNCT00000465negative
GABI, 1994balloon angioplastyCABGnegative
Lausanne, 1994balloon angioplastyCABGnegative
RITA, 1993balloon angioplastyCABGnegative
ERACI, 1992balloon angioplastyCABGnegative
Toulouse, 1992balloon angioplastyCABGnegative
sirolimus eluting stent
Kochiadakis, 2007sirolimus eluting stentbare-metal stentExploratory -
RAVEL, 2002sirolimus eluting stentbare-metal stentNCT00233805suggesting
SIRIUS, 2003sirolimus eluting stentbare-metal stentNCT00232765Low risk of bias suggesting
C-SIRIUS, 2004sirolimus eluting stentbare-metal stentNCT00381420suggesting
E-SIRIUS, 2003sirolimus eluting stentbare-metal stentNCT00235144suggesting
SES-SMART, 2004sirolimus eluting stentbare-metal stentsuggesting
DIABETES, 2005sirolimus eluting stentbare-metal stentsuggesting
Pache et al, 2005sirolimus eluting stentbare-metal stentsuggesting
PRISON II, 2006sirolimus eluting stentbare-metal stentNCT00258596Risk of bias suggesting
SCANDSTENT, 2006sirolimus eluting stentbare-metal stentNCT00151658suggesting
DECODE, 2005sirolimus eluting stentbare-metal stentNCT00489164suggesting
SCORPIUS, 2007sirolimus eluting stentbare-metal stentNCT00495898suggesting
Ortolani et al, 2007sirolimus eluting stentbare-metal stent -
Pasceri, 2003sirolimus eluting stentbare-metal stent -
GISSOC II, 2010sirolimus eluting stentbare-metal stentNCT00220558Exploratory suggesting
DESSERT, 2008sirolimus eluting stentbare-metal stentExploratory suggesting
FOCUS ongoing sirolimus eluting stentcutting ballon angioplastyNCT00485004 ongoing
MIDCAB Versus DES in Proximal LAD Lesions ongoing sirolimus eluting stentCABGNCT00299429 ongoing
Thiele, 2009PCI withsirolimus ESMIDCABNCT00299429Risk of bias -
Tomai, 2008sirolimus eluting stentpaclitaxel eluting stent -
TAXi, 2005sirolimus eluting stentpaclitaxel eluting stentRisk of bias negative
ISAR-DESIRE (SES vs PES), 2005sirolimus eluting stentpaclitaxel eluting stentsuggesting
ISAR-DIABETES, 2005sirolimus eluting stentpaclitaxel eluting stentnegative
SIRTAX (Windecker), 2005sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
CORPAL, 2005sirolimus eluting stentpaclitaxel eluting stentnegative
REALITY, 2006sirolimus eluting stentpaclitaxel eluting stentNCT00235092Risk of bias suggesting
ISAR-SMART 3, 2006sirolimus eluting stentpaclitaxel eluting stentNCT00146575negative
Zhang (SES vs PES), 2006sirolimus eluting stentpaclitaxel eluting stentExploratory negative
LONG DES II, 2006sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
Cervinka, 2006sirolimus eluting stentpaclitaxel eluting stentnegative
Petronio et al, 2007sirolimus eluting stentpaclitaxel eluting stentnegative
Han, 2006sirolimus eluting stentpaclitaxel eluting stentnegative
BASKET (vs paclitaxel), 2005sirolimus eluting stentpaclitaxel eluting stentnegative
Di Lorenzo et al., 2005sirolimus eluting stentpaclitaxel eluting stentnegative
ISAR-TEST-1, 2006sirolimus eluting stentpaclitaxel eluting stentNCT00140530Risk of bias negative
ISAR-LEFT-MAIN, 2009sirolimus eluting stentpaclitaxel eluting stentNCT00133237negative
Kim, 2008sirolimus eluting stentpaclitaxel eluting stentnegative
DES-ISR ongoing sirolimus eluting stentpaclitaxel eluting stentNCT00485030 ongoing
Lipsia-Yukon-DM ongoing sirolimus eluting stentpaclitaxel eluting stentNCT00368953 ongoing
zotarolimus eluting stent
ENDEAVOR II, 2006zotarolimus eluting stentbare-metal stentsuggesting
RESOLUTE All comers, 2010zotarolimus eluting stenteverolimus eluting stentNCT00617084.)Risk of bias negative
ENDEAVOR IV, 2009zotarolimus eluting stentpaclitaxel eluting stentNCT00217269Risk of bias suggesting
ZoMaxx phase 2 ongoing zotarolimus eluting stentpaclitaxel eluting stentNCT00140101 ongoing
ENDEAVOR III, 2006zotarolimus eluting stentsirolimus eluting stentNCT00217256suggesting
PROTECT, 2012zotarolimus eluting stentsirolimus eluting stentNCT00476957Risk of bias -
ZEST (vs SES), 2009zotarolimus eluting stentsirolimus eluting stentNCT00418067Risk of bias negative
DIABEDES IV ongoing zotarolimus eluting stentsirolimus eluting stentNCT00552994 ongoing
PRISON III, 2007 ongoing zotarolimus eluting stentsirolimus eluting stentNCT00428454 ongoing

spinal cord stimulation

not classified
de Jongste , 1994spinal cord stimulationno spinal cord stimulationExploratory -
Lanza, 2005spinal cord stimulationno spinal cord stimulationExploratory -
Eddicks, 2007spinal cord stimulationplaceboExploratory -
ESBY, 1998spinal cord stimulationcoronary artery bypass graftingExploratory -
SPIRIT, 2006spinal cord stimulationpercutaneous myocardial laser revascularizationExploratory -