hypertension  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

angioplasty

not classified
EMMA, 1998angioplastymedical therapynegative
SNRASCG, 1998angioplastymedical therapyExploratory negative
DRASTIC, 2000angioplastymedical therapyExploratory negative
ASTRAL, 2009angioplastymedical therapyRisk of bias negative
STAR, 2009angioplastymedical therapyRisk of bias negative
NITER, 2009angioplastymedical therapynegative

angiotensin-receptor blockers

not classified
Suzuki, 2008ARBscontrolRisk of bias negative
Ruilope, 2010LCZ696placeboLow risk of bias -
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias negative
VALUE, 2004valsartanamlodipineNCT00129233Low risk of bias suggesting
DETAIL, 2004telmisartanenalaprilLow risk of bias negative
OSCAR, 2011olmesartan 40 mgolmesartan 20 mg plus a calcium-channel blockerNCT00134160Risk of bias negative
candesartan
Takahashi, 2006candesartancontrolExploratory negative
E-COST, 2005candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003candesartanplaceboLow risk of bias negative
HIJ-CREATE, 2009Candesartanusual careRisk of bias -
CASE-J, 2008candesartanamlodipineRisk of bias suggesting
ALPINE, 2003candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
VALIANT/Val+Cap, 2003Valsartan + captoprilCaptoprilLow risk of bias negative
irbesartan
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias negative
IRMA 2, 2001irbesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE, 2002losartanatenololLow risk of bias suggesting
ELITE, 1997LosartanCaptoprilLow risk of bias suggesting
ELITE-II, 2000LosartanCaptoprilLow risk of bias negative
OPTIMAAL, 2001LosartanCaptoprilRisk of bias negative
ramipril
ONTARGET/Tel+Ram, 2008Telmisartan + ramiprilRamiprilLow risk of bias negative
telmisartan
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
DETAIL, 2004TelmisartanEnalaprilLow risk of bias negative
ONTARGET/Tel, 2008TelmisartanRamiprilLow risk of bias negative
valsartan
VALIANT/Val, 2003ValsartanCaptoprilLow risk of bias negative

anti hypertensive agents

not classified
Suzuki, 2008ARBscontrolRisk of bias negative
HOPE (diabetic subgroup), 2000ACE inhibitorsplaceboLow risk of bias suggesting
CASTEL (subgroup ), 1994beta-blockers + diureticsplacebonegative
STOP (subgroup ), 1991beta-blockers or diureticsplaceboLow risk of bias negative
DORADO-ACdarusentanplacebo -
DORADO, 2009darusentanplaceboNCT00330369Low risk of bias -
USPHS, 1977diuretic and rauwolfia serpentinaplaceboLow risk of bias negative
MRC old, 1992hydrochlorothiazide + amilorideplacebosuggesting
Ruilope, 2010LCZ696placeboLow risk of bias -
ACCORD (blood pressure), 2010intensiveusualNCT00000620Risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias negative
NAGOYA HEART, 2011valsartanamlodipineNCT00129233Risk of bias negative
VALUE, 2004valsartanamlodipineNCT00129233Low risk of bias suggesting
ACCOMPLISH (diabetic subgroup), 2010benazepril + amlodipinebenazepril + hydrochlorothiazideNCT00170950Low risk of bias suggesting
STOP-2 (ACEI vs CCB) (diabetic subgroup), 2000ACE inhibitorcalcium-channel blockerExploratory negative
NORDIL (diabetic subgroup), 2000diltiazemdiuretic and/or beta-blockerExploratory negative
STOP-2 (ACEI, diabetic subgroup), 2000ACE inhibitordiuretic or beta-blockerExploratory negative
STOP-2 (CCB, diabetic subgroup), 2000calcium-channel blockerdiuretic or beta-blockerExploratory negative
STOP-2 (CCB vs diurectic or beta-blocker), 1999felopidine or israpidinediuretic or beta-blockersuggesting
DETAIL, 2004telmisartanenalaprilLow risk of bias negative
OSCAR, 2011olmesartan 40 mgolmesartan 20 mg plus a calcium-channel blockerNCT00134160Risk of bias negative
AASK (amlodipine vs ramipril), 2002amlodipineramiprilLow risk of bias negative
aliskiren
ACCELERATE, 2011aliskiren amlodipine NCT00797862 -
AVOID, 2008aliskirenplaceboNCT00097955Low risk of bias negative
Schmieder (vs HCTZ), 2009aliskirenhydrochlorothiazideLow risk of bias negative
ALLAY, 2009aliskirenlosartanNCT00219141Exploratory negative
Andersen, 2008aliskirenramiprilLow risk of bias -
amlodipine
IDNT (amlodipine vs PBO), 2001amlodipineplaceboLow risk of bias negative
IDNT (amlodipine vs pbo), 2001amlodipineplaceboLow risk of bias negative
Tepel et al, 2008amlodipineplaceboNCT00124969Low risk of bias negative
ASCOT-BPLA, 2005amlodipineatenololRisk of bias suggesting
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidoneLow risk of bias negative
ALLHAT (CCB vs diu), 2002amlodipinechlorthalidonenegative
FACET, 1997amlodipinefosinoprilRisk of bias suggesting
ACCOMPLISH, 2008amlodipine plus benazeprilhydrochlorothiazide plus benazeprilNCT00170950Low risk of bias suggesting
ALLHAT (CCB vs ACEI), 2002amlodipinelisinoprilsuggesting
AASK (amlodipine vs metoprolol), 2002amlodipinemetoprololnegative
atenolol
Coope, 1986atenololcontrol suggesting
Coope (subgroup ), 1986atenololcontrolLow risk of bias negative
MRC old (vs placebo), 1992atenololplaceboLow risk of bias negative
MRC I (vs placebo), 1985atenololplaceboLow risk of bias suggesting
Dutch TIA, 1993atenololplaceboLow risk of bias suggesting
TEST, 1995atenololplacebonegative
MRC I (vs diuretics), 1985atenololbendroflumethiazideLow risk of bias negative
MRC old (vs diuretics), 1992atenololhydrochlorothiazide+amilorideLow risk of bias negative
candesartan
Takahashi, 2006candesartancontrolExploratory negative
E-COST, 2005candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003candesartanplaceboLow risk of bias negative
TROPHY, 2006candesartanplaceboNCT00227318Low risk of bias suggesting
HSCS, 1974deserpidine +methylclothiazideplaceboLow risk of bias negative
Takahashi et al, 2006candesartanusual caresuggesting
Suzuki et al, 2008candesartanusual caresuggesting
CASE-J, 2008candesartanamlodipineRisk of bias suggesting
ALPINE, 2003candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
UKPDS 38, 1998captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockersExploratory suggesting
UKPDS-HDS, 1998captoprildiuretic or beta-blockernegative
CAPPP, 1999captoprildiuretic or beta-blockerRisk of bias negative
carvedilol
Cice et al, 2003carvedilolplacebosuggesting
Nakao et al, 2007carvedilolplacebo -
chlorthalidone
SHEP (diabetic subgroup), 1996chlorthalidoneplaceboLow risk of bias suggesting
VA-NHLBI, 1977chlorthalidoneplacebonegative
SHEP, 1991chlorthalidoneplaceboNCT00000514Low risk of bias suggesting
SHEP-pilot, 1989chlorthalidoneplaceboLow risk of bias negative
SHEP-P (subgroup ), 1989chlorthalidoneplaceboLow risk of bias suggesting
SHEP (subgroup ), 1991chlorthalidoneplaceboLow risk of bias suggesting
diltiazem
NORDIL, 2000diltiazemdiuretic or beta-blockersuggesting
enalapril
ANBP2, 2003enalaprildiureticsRisk of bias negative
ABCD (H), 1998enalaprilnisoldipineLow risk of bias suggesting
fosinopril
Zannad et al, 2006fosinoprilplaceboLow risk of bias negative
hydrochlorothiazide
EWPHE (subgroup ), 1985hydrochlorothiazideplaceboLow risk of bias negative
Kuramoto, 1981hydrochlorothiazide + triamtereneplaceboLow risk of bias negative
EWPHE, 1985hydrochlorothiazide + triamtereneplaceboLow risk of bias suggesting
indapamide
HYVET pilot, 2003 -
HYVET, 2008indapamideplaceboNCT00122811Low risk of bias suggesting
PATS, 1995indapamideplaceboLow risk of bias negative
HAPPY, 1987negative
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IRMA 2, 2001irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
isradipine
MIDAS, 1996isradipinehydrochlorothiazidenegative
lacidipine
ELSA, 2002lacidipineatenololLow risk of bias -
SHELL, 2003lacidipinechlorthalidone -
lisinopril
ALLHAT (ACEI vs amlodipine), 2002lisinoprilamlodipineLow risk of bias suggesting
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidoneLow risk of bias negative
ALLHAT (ACEI vs chlorthalidone), 2002lisinoprildiureticsLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE (diabetic subgroup), 2002losartanatenololLow risk of bias suggesting
LIFE, 2002losartanatenololLow risk of bias suggesting
nicardipine
NICS-EH, 1999nicardipinetrichlormethiazideLow risk of bias negative
nidrendipine
Syst-Eur (subgroup ), 1997nidrendipineplaceboLow risk of bias negative
SYST-EUR, 1997nitrendipineplacebosuggesting
Syst-Eur (diabetic subgroup), 1999nitrendipineplaceboLow risk of bias suggesting
nifedipine
Castel, 1994nifedipineatenolol+chlorthalidonenegative
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozideLow risk of bias negative
INSIGHT, 2000nifedipinehydrochlorothiazide+amilorideLow risk of bias suggesting
nisoldipine
ABCD (hypertension), 1998nisoldipineenalaprilLow risk of bias suggesting
oxprenolol
IPPPSH, 1985oxprenololplaceboLow risk of bias negative
propranolol
Berglund, 1986propranololbendroflumethiazidenegative
ramipril
Li et al, 2003ramiprilusual carenegative
AASK (ramipril vs amlodipine), 2002ramiprilamlodipineLow risk of bias negative
AASK (ramipril vs metoprolol), 2002ramiprilmetoprololLow risk of bias negative
telmisartan
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
Cice et al, 2006telmisartanplacebosuggesting
thiazid diuretic
ANBPS (Australian ), 1980thiazide diureticscontrolLow risk of bias negative
Oslo (Hegeland), 1980thiazide diureticscontrolnegative
Carter, 1970thiazide diureticscontrolsuggesting