hypertension

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

angioplasty

not classified
EMMA, 1998     angioplastymedical therapynegative
SNRASCG, 1998   angioplastymedical therapyExploratory negative
DRASTIC, 2000     angioplastymedical therapyExploratory negative
ASTRAL, 2009     angioplastymedical therapyRisk of bias negative
STAR, 2009   angioplastymedical therapyRisk of bias negative
NITER, 2009   angioplastymedical therapynegative

angiotensin-receptor blockers

not classified
Suzuki, 2008     ARBscontrolRisk of bias negative
Ruilope, 2010   LCZ696placeboLow risk of bias -
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias negative
VALUE, 2004      NCTvalsartanamlodipineLow risk of bias suggesting
DETAIL, 2004     telmisartanenalaprilLow risk of bias negative
OSCAR, 2011      NCTolmesartan 40 mgolmesartan 20 mg plus a calcium-channel blockerRisk of bias negative
candesartan
Takahashi, 2006     candesartancontrolExploratory negative
E-COST, 2005     candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005     candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009     candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003   candesartanplaceboLow risk of bias negative
HIJ-CREATE, 2009     Candesartanusual careRisk of bias -
CASE-J, 2008     candesartanamlodipineRisk of bias suggesting
ALPINE, 2003   candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
VALIANT/Val+Cap, 2003       Valsartan + captoprilCaptoprilLow risk of bias negative
irbesartan
IDNT (irbesartan vs pbo), 2001       irbesartanplaceboLow risk of bias negative
IRMA 2, 2001     irbesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting
ELITE, 1997     LosartanCaptoprilLow risk of bias suggesting
ELITE-II, 2000     LosartanCaptoprilLow risk of bias negative
OPTIMAAL, 2001     LosartanCaptoprilRisk of bias negative
ramipril
ONTARGET/Tel+Ram, 2008     Telmisartan + ramiprilRamiprilLow risk of bias negative
telmisartan
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative
DETAIL, 2004     TelmisartanEnalaprilLow risk of bias negative
ONTARGET/Tel, 2008     TelmisartanRamiprilLow risk of bias negative
valsartan
VALIANT/Val, 2003       ValsartanCaptoprilLow risk of bias negative

anti hypertensive agents

not classified
Suzuki, 2008     ARBscontrolRisk of bias negative
HOPE (diabetic subgroup), 2000       ACE inhibitorsplaceboLow risk of bias suggesting
CASTEL (subgroup ), 1994   beta-blockers + diureticsplacebonegative
STOP (subgroup ), 1991     beta-blockers or diureticsplaceboLow risk of bias negative
DORADO-AC   darusentanplacebo -
DORADO, 2009    NCTdarusentanplaceboLow risk of bias -
USPHS, 1977   diuretic and rauwolfia serpentinaplaceboLow risk of bias negative
MRC old, 1992   hydrochlorothiazide + amilorideplacebosuggesting
Ruilope, 2010   LCZ696placeboLow risk of bias -
ACCORD (blood pressure), 2010          NCTintensiveusualRisk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias negative
NAGOYA HEART, 2011      NCTvalsartanamlodipineRisk of bias negative
VALUE, 2004      NCTvalsartanamlodipineLow risk of bias suggesting
ACCOMPLISH (diabetic subgroup), 2010        NCTbenazepril + amlodipinebenazepril + hydrochlorothiazideLow risk of bias suggesting
STOP-2 (ACEI vs CCB) (diabetic subgroup), 2000       ACE inhibitorcalcium-channel blockerExploratory negative
NORDIL (diabetic subgroup), 2000     diltiazemdiuretic and/or beta-blockerExploratory negative
STOP-2 (ACEI, diabetic subgroup), 2000       ACE inhibitordiuretic or beta-blockerExploratory negative
STOP-2 (CCB, diabetic subgroup), 2000       calcium-channel blockerdiuretic or beta-blockerExploratory negative
STOP-2 (CCB vs diurectic or beta-blocker), 1999     felopidine or israpidinediuretic or beta-blockersuggesting
DETAIL, 2004     telmisartanenalaprilLow risk of bias negative
OSCAR, 2011      NCTolmesartan 40 mgolmesartan 20 mg plus a calcium-channel blockerRisk of bias negative
AASK (amlodipine vs ramipril), 2002     amlodipineramiprilLow risk of bias negative
aliskiren
ACCELERATE, 2011    NCTaliskiren amlodipine -
AVOID, 2008      NCTaliskirenplaceboLow risk of bias negative
Schmieder (vs HCTZ), 2009     aliskirenhydrochlorothiazideLow risk of bias negative
ALLAY, 2009      NCTaliskirenlosartanExploratory negative
Andersen, 2008     aliskirenramiprilLow risk of bias -
amlodipine
IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative
IDNT (amlodipine vs pbo), 2001     amlodipineplaceboLow risk of bias negative
Tepel et al, 2008      NCTamlodipineplaceboLow risk of bias negative
ASCOT-BPLA, 2005     amlodipineatenololRisk of bias suggesting
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002       amlodipinechlorthalidoneLow risk of bias negative
ALLHAT (CCB vs diu), 2002     amlodipinechlorthalidonenegative
FACET, 1997     amlodipinefosinoprilRisk of bias suggesting
ACCOMPLISH, 2008        NCTamlodipine plus benazeprilhydrochlorothiazide plus benazeprilLow risk of bias suggesting
ALLHAT (CCB vs ACEI), 2002     amlodipinelisinoprilsuggesting
AASK (amlodipine vs metoprolol), 2002     amlodipinemetoprololnegative
atenolol
Coope, 1986   atenololcontrol suggesting
Coope (subgroup ), 1986   atenololcontrolLow risk of bias negative
MRC old (vs placebo), 1992   atenololplaceboLow risk of bias negative
MRC I (vs placebo), 1985   atenololplaceboLow risk of bias suggesting
Dutch TIA, 1993   atenololplaceboLow risk of bias suggesting
TEST, 1995   atenololplacebonegative
MRC I (vs diuretics), 1985   atenololbendroflumethiazideLow risk of bias negative
MRC old (vs diuretics), 1992   atenololhydrochlorothiazide+amilorideLow risk of bias negative
candesartan
Takahashi, 2006     candesartancontrolExploratory negative
E-COST, 2005     candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005     candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009     candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003   candesartanplaceboLow risk of bias negative
TROPHY, 2006      NCTcandesartanplaceboLow risk of bias suggesting
HSCS, 1974   deserpidine +methylclothiazideplaceboLow risk of bias negative
Takahashi et al, 2006     candesartanusual caresuggesting
Suzuki et al, 2008     candesartanusual caresuggesting
CASE-J, 2008     candesartanamlodipineRisk of bias suggesting
ALPINE, 2003   candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998     captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting
UKPDS-HDS, 1998       captoprildiuretic or beta-blockernegative
CAPPP, 1999     captoprildiuretic or beta-blockerRisk of bias negative
carvedilol
Cice et al, 2003     carvedilolplacebosuggesting
Nakao et al, 2007   carvedilolplacebo -
chlorthalidone
SHEP (diabetic subgroup), 1996   chlorthalidoneplaceboLow risk of bias suggesting
VA-NHLBI, 1977   chlorthalidoneplacebonegative
SHEP, 1991      NCTchlorthalidoneplaceboLow risk of bias suggesting
SHEP-pilot, 1989   chlorthalidoneplaceboLow risk of bias negative
SHEP-P (subgroup ), 1989   chlorthalidoneplaceboLow risk of bias suggesting
SHEP (subgroup ), 1991   chlorthalidoneplaceboLow risk of bias suggesting
diltiazem
NORDIL, 2000     diltiazemdiuretic or beta-blockersuggesting
enalapril
ANBP2, 2003     enalaprildiureticsRisk of bias negative
ABCD (H), 1998     enalaprilnisoldipineLow risk of bias suggesting
fosinopril
Zannad et al, 2006     fosinoprilplaceboLow risk of bias negative
hydrochlorothiazide
EWPHE (subgroup ), 1985   hydrochlorothiazideplaceboLow risk of bias negative
Kuramoto, 1981   hydrochlorothiazide + triamtereneplaceboLow risk of bias negative
EWPHE, 1985   hydrochlorothiazide + triamtereneplaceboLow risk of bias suggesting
indapamide
HYVET pilot, 2003   -
HYVET, 2008    NCTindapamideplaceboLow risk of bias suggesting
PATS, 1995   indapamideplaceboLow risk of bias negative
HAPPY, 1987   negative
intensive blood pressure lowering strategies
ABCD target (H) , 2000   more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002     more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting
IRMA 2, 2001     irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs pbo), 2001       irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting
isradipine
MIDAS, 1996   isradipinehydrochlorothiazide