heart failure

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathhospitalisation for heart failure

aldosterone blockade

eplerenone
EPHESUS, 2003       eplerenoneplaceboLow risk of bias suggesting -14%
EMPHASIS-HF, 2010        NCTeplerenoneplaceboLow risk of bias suggesting -19%-35%
spironolactone
Cicoira, 2004     spironolactonecontrol -
Cicoira, 2002     spironolactonecontrolExploratory -
Ramires, 2000     spironolactonecontrolExploratory -
RALES, 1998         spironolactoneplaceboRisk of bias suggesting -25%
Agostoni, 2005     spironolactoneplaceboExploratory -
Mottram, 2004     spironolactoneplaceboLow risk of bias -
Macdonald, 2004     spironolactoneplaceboLow risk of bias -
Yee, 2001     spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001     spironolactoneplaceboLow risk of bias -
Farquharson, 2000     spironolactoneplaceboLow risk of bias -
MacFadyen, 1997     spironolactoneplaceboLow risk of bias -
Han, 1994     spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000     aldactonefurosemideExploratory -
Mauersberger, 1985     spironolactone+furosemidespironolactone+butizideExploratory -

angiotensin-Converting Enzyme Inhibitors

not classified
CASSIS (spirapril), 1995   spiraprilplaceboLow risk of bias -
benazepril
McGany, 1991   benazeprilcontrolnegative
Colfer, 1992   benazeprilplaceboLow risk of bias negative
captopril
Magnani, 1986   captoprilplaceboLow risk of bias -
Bussmann, 1987   captoprilplaceboLow risk of bias negative-39%
Captopril Digoxin Multicenter Research Group, 1988   captoprilplaceboLow risk of bias negative
Barabino, 1991   captoprilplaceboLow risk of bias suggesting
Munich MHFT (Kleber), 1992   captoprilplaceboLow risk of bias negative5%
Magnani, 1990   captoprilplaceboLow risk of bias -
CMRG, 1983   captoprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995   captoprilplaceboLow risk of bias -
SAVE, 1992   captoprilplaceboLow risk of bias -
Pfeffer, 1988   captoprilplaceboLow risk of bias -
Sogaard, 1994   captoprilplaceboLow risk of bias -
Sharpe, 1988     captoprilplaceboLow risk of bias -
Mortarino, 1990   captoprilplaceboLow risk of bias -
packer, 1986   captoprilenalaprilExploratory -
cilazapril
Drexler, 1989   cilazaprilplaceboLow risk of bias negative
Dosseger, 1993   cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group, 1995   cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995   cilazaprilcaptoprilLow risk of bias -
enalapril
Rucinska-b (enalapril), 1991   enalaprilcontrolnegative
Enalapril CHF investigators, 1987   enalaprilcontrolnegative
Rucinska-a (enalapril), 1991   enalaprilcontrolnegative
SOLVD treatment, 1991    NCTenalaprilplaceboLow risk of bias suggesting -11%-29%
SOLVD prevention, 1992    NCTenalaprilplaceboLow risk of bias -
Cleland, 1985   enalaprilplaceboLow risk of bias negative
CONSENSUS, 1987   enalaprilplaceboLow risk of bias negative
Dickstein, 1991   enalaprilplaceboLow risk of bias negative
Sharpe, 1984   enalaprilplaceboLow risk of bias -
McGrath, 1985     enalaprilplaceboLow risk of bias -
Chrysant, 1985   enalaprilplaceboLow risk of bias -
CASSIS (enalapril), 1995   enalaprilplaceboLow risk of bias -
NETWORK (2.5 bid vs 10 bid), 1998   enalaprilenalaprilLow risk of bias -
NETWORK (5 bid vs 10 bid), 1998   enalaprilenalaprilLow risk of bias -
V-HeFT II, 1991   enalaprilhydralazine+ISDNLow risk of bias -
fosinopril
Brown, 1995     fosinoprilplaceboLow risk of bias -
FEST (Erhardt), 1996     fosinoprilplaceboLow risk of bias -
lisinopril
Zwehl, 1990   lisinoprilcontrolnegative
Giles, 1990   lisinoprilcontrolnegative
Rucinska-c (lisinopril), 1000   lisinoprilcontrolnegative
Gilbert, 1993   lisinoprilplaceboLow risk of bias negative
International Study Group (Lewis), 1989   lisinoprilplaceboLow risk of bias -
ATLAS, 1999   lisinoprillisinoprilLow risk of bias -
perindopril
Lechat, 1993   perindoprilplaceboLow risk of bias negative
PEP CHF, 2006   perindoprilplaceboLow risk of bias negative -10%-36%
quinapril
Uprichard-a, 1994   controlnegative
Uprichard-b, 1994   controlnegative
Uprichard-c, 1994   controlnegative
Riegger, 1990   placeboLow risk of bias negative
Northridge, 1991     placeboLow risk of bias negative
Rieger, 1991   placeboLow risk of bias negative
Nussberger, 1994   placeboLow risk of bias -
Quinapril Heart Failure Trial Investigators, 1993   placeboLow risk of bias -
ramipril
Swedberg, 1991   ramiprilcontrolnegative
Maass-a, 1991   ramiprilplacebonegative
Gordon, 1991     ramiprilplaceboLow risk of bias suggesting
Maass-b, 1991   ramiprilplaceboLow risk of bias negative
Maass-c, 1991     ramiprilplaceboLow risk of bias negative
Lemarie, 1992     ramiprilplaceboLow risk of bias negative
Gundersen, 1994     ramiprilplaceboLow risk of bias -
AIRE, 1993   ramiprilplaceboLow risk of bias -
trandolapril
Hampton, 1998     trandolaprilplaceboLow risk of bias -
TRACE, 1995     trandolaprilplaceboLow risk of bias -

angiotensin-receptor blockers

not classified
ADEPT, 2001     eprosartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
candesartan
ARCH-J, 2003     candesartanplaceboLow risk of bias -
CHARM-Alternative, 2003     candesartanplaceboLow risk of bias suggesting
Mitrovic et al., 2003     candesartanplaceboLow risk of bias suggesting
SPICE, 2000     candesartanplaceboLow risk of bias negative2%-31%
STRETCH, 1999     candesartanplaceboLow risk of bias -
CHARM preserved, 2003   candesartanplaceboLow risk of bias -
CHARM-Added, 2003       candesartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
RESOLVD association, 1999     candesartan+ACE inhibitorACE inhibitor onlyExploratory negative
RESOLVD (candesartan alone), 1999     candesartanenalaprilLow risk of bias negative
irbesartan
I-PRESERVE (McMurray), 2008      NCTibesartanplaceboLow risk of bias negative2%-4%
Tonkon et al., 2000   irbesartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
losartan
HEAAL, 2009        NCTlosartan 150mglosartan 50mgLow risk of bias suggesting-6%-13%
Losartan Phase III International, 1996       losartanplaceboLow risk of bias suggesting-83%
Losartan Phase III U.S., 1995     losartanplaceboLow risk of bias negative-52%
Hamroff et al., 1999     losartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
ELITE, 1997       losartancaptoprilLow risk of bias negative
ELITE II, 2000     losartancaptoprilLow risk of bias -
Dickstein et al., 1995     losartanenalaprilLow risk of bias -
Lang et al., 1997     losartanenalaprilLow risk of bias -
Losartan phase II S, 1996     losartanenalaprilLow risk of bias -
losartan phase II US, 1996     losartanenalaprilLow risk of bias -
telmisartan
REPLACE, 2001     telmisartanenalaprilLow risk of bias -
valsartan
VALIDD, 2007    NCTvalsartanno valsartanLow risk of bias negative
Mazayev et al. (vs placebo), 1998     valsartanplaceboLow risk of bias -
V-HeFT, 1999     valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
Val-HeFT, 2001     valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias suggesting 2%-24%
HEAVEN, 2002     valsartanenalaprilLow risk of bias -
Mazayev et al. (vs lisinopril, 1998     valsartanLisinoprilExploratory -

anti inflammatory drugs

not classified
ACCLAIM, 2008      NCTCelacade™ systemplaceboLow risk of bias negative

antiarrythmic drugs

amiodarone
EPAMSA, 1985   amiodaroneno treatmentsuggesting-61%
GESICA, 1994   amiodaroneno treatmentsuggesting-28%
Hamer, 1989   amiodaroneplaceboLow risk of bias suggesting-25%
Nicklas, 1991   amiodaroneplaceboLow risk of bias negative54%
STATCHF, 1995     amiodaroneplaceboLow risk of bias negative-6%
AMIOVIRT, 2003     amiodaroneICDnegative14%
dronedarone
ANDROMEDA, 2008      NCTdronedaroneplaceboLow risk of bias negative 113%

anticoagulant

rivaroxaban
COMMANDER HF, 2018      NCTrivaroxabanplacebonegative-2%
warfarin
HELAS (warfarin vs placebo), 2006   warfarinplaceboLow risk of bias -
HELAS (warfarin vs aspirin), 2006   warfarinaspirinLow risk of bias -
WATCH (warfarin vs aspirin), 2009      NCTwarfarinaspirinsuggesting-5%

antithrombotics

not classified
Barzizza (A+D), 1993   placebo -
aspirin
WASH (aspirin), 2004     aspirinno treatmentnegative 40%
Barzizza (ASA), 1993   aspirinplaceboExploratory -
enoxaparin
THE-PRINCE (Kleber), 2003     enoxaparinUFH -
rivaroxaban
COMMANDER HF, 2018      NCTrivaroxabanplacebonegative-2%
warfarin
WASH (warfarin), 2004     warfarinno treatmentnegative17%
HELAS (warfarin vs placebo), 2006   warfarinplaceboLow risk of bias -
Barzizza (warfarin), 1993   warfarinplacebo -
HELAS (warfarin vs aspirin), 2006   warfarinaspirinLow risk of bias -
WATCH (warfarin vs aspirin), 2009      NCTwarfarinaspirinsuggesting-5%

beta-blockers

bisoprolol
CIBIS, 1994     bisoprololplaceboLow risk of bias suggesting-21%-34%
CIBIS II, 1999     bisoprololplaceboLow risk of bias suggesting-32%
CIBIS II (elderly subgroup), 1999       Bisoprololplacebosuggesting-30%
bucindolol
BEST, 2001    NCTbucindololplaceboLow risk of bias suggesting-8%-16%
Pollock, 1990   BucindololplaceboLow risk of bias -
Woodley, 1991   Bucindololplacebo -
Bristow, 1994   Bucindololplacebo -
MERIT-HF (elderly subgroup), 1999     Bucindololplacebosuggesting-30%
carvedilol
ANZ-HeFT, 1997         carvedilolplaceboLow risk of bias negative-23%-30%
COPERNICUS, 2002     carvedilolplaceboLow risk of bias suggesting-33%-33%
CAPRICORN, 2001   carvedilolplaceboLow risk of bias suggesting-22%-14%
Metra, 1994   carvedilolplacebo -
Olsen, 1995     carvedilolplacebo -
Krum, 1995     carvedilolplacebo -
Bristow (MOCHA), 1996     carvedilolplaceboLow risk of bias -
Parker, 1996       carvedilolplaceboLow risk of bias negative
Colucci, 1996     carvedilolplaceboLow risk of bias -
Cohn, 1997     carvedilolplacebo -
Carvedilol U.S. Trials (elderly subgroup), 1996     Carvedilolplacebosuggesting-55%
COPERNICUS (elderly subgroup), 2001     Carvedilolplacebosuggesting-25%
CARMEN (carvedilol alone), 2004   carvedilolenalaprilnegative-1%-25%
COMET, 2003   carvedilolmetoprololLow risk of bias suggesting-14%
metoprolol
MDC (Waagstein), 1993   metoprololplaceboLow risk of bias negative7%-26%
MERIT-HF, 1999       metoprololplaceboLow risk of bias suggesting-33%
Engelmeier, 1985   metoprololplacebo -
Fisher, 1994   metoprololplacebo -
Eichhorn, 1994   metoprololplacebo -
RESOLVD, 2000     metoprololplacebo -
BEST (elderly subgroup), 2001     Metoprololplacebonegative-9%
nebivolol
Lechat, 1991   Nebivololplacebo -
Wisenbaugh, 1993   NebivololplaceboLow risk of bias negative+Infini%
SENIORS, 2005     nebivololplaceboLow risk of bias -

BNP guided management

not classified
TIME CHF, 2009     BNP-guided managementcontrolRisk of bias negative-32%
PRIMA     BNP-guided managementcontrolRisk of bias negative-19%
PROTECT, 2009    NCTBNP-guided managementcontrol -
STARS-BNP, 2007   BNP-guided managementcontrolRisk of bias suggesting
BATTLESCARRED, 2009   BNP-guided managementcontrolRisk of bias negative1%
STARBRITE, 2007    NCTBNP-guided managementcontrol -
Troughton, 2000   BNP-guided managementcontrolRisk of bias suggesting-84%

calcium channel blockers

not classified
De Vries, 1996     placeboLow risk of bias -
amlodipine
Packer, 1991   amlodipinecontrolLow risk of bias -
Smith, 1994     amlodipinecontrolLow risk of bias -
Udelson, 1996   amlodipinecontrolLow risk of bias -
Binkley, 1996   amlodipinecontrolLow risk of bias -
Ghali, 1997   amlodipinecontrolLow risk of bias -
PRAISE, 1996     amlodipineplaceboLow risk of bias negative-13%
PRAISE II , 2000     AmlodipineplaceboLow risk of bias negative6%
diltiazem
Liao , 1998     DiltiazemplaceboExploratory suggesting-69%-74%
DiDi, 1996     diltiazemplaceboLow risk of bias negative2%
felodipine
VHeFT III, 1997     felodipineplaceboLow risk of bias negative8%
Kassis, 1987   felodipineplaceboLow risk of bias -
Littler, 1995   FelodipineplaceboLow risk of bias negative35%
Kassis, 1990   felodipineplaceboLow risk of bias -
Dunselman, 1990   felodipineenalaprilLow risk of bias -
De Vries, 1995     felodipineenalaprilLow risk of bias -
isradipine
Van den Toren, 1996     isradipineplaceboLow risk of bias -
mibefradil
MACH 1, 2000     mibefradilplaceboLow risk of bias suggesting10%-15%
nicardipine
Gheorghiade, 1991   nicardipinecontrolLow risk of bias -
Abrams, 1993   nicardipinecontrolLow risk of bias -
nisoldipine
Gaudron, 1996   NisoldipineplaceboExploratory -
Rousseau, 1994   nisoldipineplaceboLow risk of bias -
Schofer, 1990   nisoldipinecaptoprilLow risk of bias -

cell-based therapies

not classified
Revive      -
POSEIDON, 2012      NCTMesenchymal stem cellsallogeneic mesenchymal stem cells -
Pokushalov (DOUBLON DIB), 2010   Bone marrow derived stem cellcontrol -
FOCUS-CCTRN, 2012      NCTBone marrow derived stem cellcontrol -