heart failure

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

aldosterone blockade

eplerenone
EPHESUS, 2003       eplerenoneplaceboLow risk of bias suggesting
EMPHASIS-HF, 2010        NCTeplerenoneplaceboLow risk of bias suggesting
spironolactone
Cicoira, 2004     spironolactonecontrol -
Cicoira, 2002     spironolactonecontrolExploratory -
Ramires, 2000     spironolactonecontrolExploratory -
RALES, 1998         spironolactoneplaceboRisk of bias suggesting
Agostoni, 2005     spironolactoneplaceboExploratory -
Mottram, 2004     spironolactoneplaceboLow risk of bias -
Macdonald, 2004     spironolactoneplaceboLow risk of bias -
Yee, 2001     spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001     spironolactoneplaceboLow risk of bias -
Farquharson, 2000     spironolactoneplaceboLow risk of bias -
MacFadyen, 1997     spironolactoneplaceboLow risk of bias -
Han, 1994     spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000     aldactonefurosemideExploratory -
Mauersberger, 1985     spironolactone+furosemidespironolactone+butizideExploratory -

angiotensin-Converting Enzyme Inhibitors

not classified
CASSIS (spirapril), 1995   spiraprilplaceboLow risk of bias -
benazepril
McGany, 1991   benazeprilcontrolnegative
Colfer, 1992   benazeprilplaceboLow risk of bias negative
captopril
Magnani, 1986   captoprilplaceboLow risk of bias -
Bussmann, 1987   captoprilplaceboLow risk of bias negative
Captopril Digoxin Multicenter Research Group, 1988   captoprilplaceboLow risk of bias negative
Barabino, 1991   captoprilplaceboLow risk of bias suggesting
Munich MHFT (Kleber), 1992   captoprilplaceboLow risk of bias negative
Magnani, 1990   captoprilplaceboLow risk of bias -
CMRG, 1983   captoprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995   captoprilplaceboLow risk of bias -
SAVE, 1992   captoprilplaceboLow risk of bias -
Pfeffer, 1988   captoprilplaceboLow risk of bias -
Sogaard, 1994   captoprilplaceboLow risk of bias -
Sharpe, 1988     captoprilplaceboLow risk of bias -
Mortarino, 1990   captoprilplaceboLow risk of bias -
packer, 1986   captoprilenalaprilExploratory -
cilazapril
Drexler, 1989   cilazaprilplaceboLow risk of bias negative
Dosseger, 1993   cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group, 1995   cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995   cilazaprilcaptoprilLow risk of bias -
enalapril
Rucinska-b (enalapril), 1991   enalaprilcontrolnegative
Enalapril CHF investigators, 1987   enalaprilcontrolnegative
Rucinska-a (enalapril), 1991   enalaprilcontrolnegative
SOLVD treatment, 1991    NCTenalaprilplaceboLow risk of bias suggesting
SOLVD prevention, 1992    NCTenalaprilplaceboLow risk of bias -
Cleland, 1985   enalaprilplaceboLow risk of bias negative
CONSENSUS, 1987   enalaprilplaceboLow risk of bias negative
Dickstein, 1991   enalaprilplaceboLow risk of bias negative
Sharpe, 1984   enalaprilplaceboLow risk of bias -
McGrath, 1985     enalaprilplaceboLow risk of bias -
Chrysant, 1985   enalaprilplaceboLow risk of bias -
CASSIS (enalapril), 1995   enalaprilplaceboLow risk of bias -
NETWORK (2.5 bid vs 10 bid), 1998   enalaprilenalaprilLow risk of bias -
NETWORK (5 bid vs 10 bid), 1998   enalaprilenalaprilLow risk of bias -
V-HeFT II, 1991   enalaprilhydralazine+ISDNLow risk of bias -
fosinopril
Brown, 1995     fosinoprilplaceboLow risk of bias -
FEST (Erhardt), 1996     fosinoprilplaceboLow risk of bias -
lisinopril
Zwehl, 1990   lisinoprilcontrolnegative
Giles, 1990   lisinoprilcontrolnegative
Rucinska-c (lisinopril), 1000   lisinoprilcontrolnegative
Gilbert, 1993   lisinoprilplaceboLow risk of bias negative
International Study Group (Lewis), 1989   lisinoprilplaceboLow risk of bias -
ATLAS, 1999   lisinoprillisinoprilLow risk of bias -
perindopril
Lechat, 1993   perindoprilplaceboLow risk of bias negative
PEP CHF, 2006   perindoprilplaceboLow risk of bias negative
quinapril
Uprichard-a, 1994   controlnegative
Uprichard-b, 1994   controlnegative
Uprichard-c, 1994   controlnegative
Riegger, 1990   placeboLow risk of bias negative
Northridge, 1991     placeboLow risk of bias negative
Rieger, 1991   placeboLow risk of bias negative
Nussberger, 1994   placeboLow risk of bias -
Quinapril Heart Failure Trial Investigators, 1993   placeboLow risk of bias -
ramipril
Swedberg, 1991   ramiprilcontrolnegative
Maass-a, 1991   ramiprilplacebonegative
Gordon, 1991     ramiprilplaceboLow risk of bias suggesting
Maass-b, 1991   ramiprilplaceboLow risk of bias negative
Maass-c, 1991     ramiprilplaceboLow risk of bias negative
Lemarie, 1992     ramiprilplaceboLow risk of bias negative
Gundersen, 1994     ramiprilplaceboLow risk of bias -
AIRE, 1993   ramiprilplaceboLow risk of bias -
trandolapril
Hampton, 1998     trandolaprilplaceboLow risk of bias -
TRACE, 1995     trandolaprilplaceboLow risk of bias -

angiotensin-receptor blockers

not classified
ADEPT, 2001     eprosartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
candesartan
ARCH-J, 2003     candesartanplaceboLow risk of bias -
CHARM-Alternative, 2003     candesartanplaceboLow risk of bias suggesting
Mitrovic et al., 2003     candesartanplaceboLow risk of bias suggesting
SPICE, 2000     candesartanplaceboLow risk of bias negative
STRETCH, 1999     candesartanplaceboLow risk of bias -
CHARM preserved, 2003   candesartanplaceboLow risk of bias -
CHARM-Added, 2003       candesartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
RESOLVD association, 1999     candesartan+ACE inhibitorACE inhibitor onlyExploratory negative
RESOLVD (candesartan alone), 1999     candesartanenalaprilLow risk of bias negative
irbesartan
I-PRESERVE (McMurray), 2008      NCTibesartanplaceboLow risk of bias negative
Tonkon et al., 2000   irbesartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
losartan
HEAAL, 2009        NCTlosartan 150mglosartan 50mgLow risk of bias suggesting
Losartan Phase III International, 1996       losartanplaceboLow risk of bias suggesting
Losartan Phase III U.S., 1995     losartanplaceboLow risk of bias negative
Hamroff et al., 1999     losartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
ELITE, 1997       losartancaptoprilLow risk of bias negative
ELITE II, 2000     losartancaptoprilLow risk of bias -
Dickstein et al., 1995     losartanenalaprilLow risk of bias -
Lang et al., 1997     losartanenalaprilLow risk of bias -
Losartan phase II S, 1996     losartanenalaprilLow risk of bias -
losartan phase II US, 1996     losartanenalaprilLow risk of bias -
telmisartan
REPLACE, 2001     telmisartanenalaprilLow risk of bias -
valsartan
VALIDD, 2007    NCTvalsartanno valsartanLow risk of bias negative
Mazayev et al. (vs placebo), 1998     valsartanplaceboLow risk of bias -
V-HeFT, 1999     valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
Val-HeFT, 2001     valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias suggesting
HEAVEN, 2002     valsartanenalaprilLow risk of bias -
Mazayev et al. (vs lisinopril, 1998     valsartanLisinoprilExploratory -

anti inflammatory drugs

not classified
ACCLAIM, 2008      NCTCelacade™ systemplaceboLow risk of bias negative

antiarrythmic drugs

amiodarone
EPAMSA, 1985   amiodaroneno treatmentsuggesting
GESICA, 1994   amiodaroneno treatmentsuggesting
Hamer, 1989   amiodaroneplaceboLow risk of bias suggesting
Nicklas, 1991   amiodaroneplaceboLow risk of bias negative
STATCHF, 1995     amiodaroneplaceboLow risk of bias negative
AMIOVIRT, 2003     amiodaroneICDnegative
dronedarone
ANDROMEDA, 2008      NCTdronedaroneplaceboLow risk of bias negative

antithrombotics

not classified
Barzizza (A+D), 1993   placebo -
aspirin
WASH (aspirin), 2004     aspirinno treatmentnegative
Barzizza (ASA), 1993   aspirinplaceboExploratory -
enoxaparin
THE-PRINCE (Kleber), 2003     enoxaparinUFH -
warfarin
WASH (warfarin), 2004     warfarinno treatmentnegative
HELAS (warfarin vs placebo), 2006   warfarinplaceboLow risk of bias -
Barzizza (warfarin), 1993   warfarinplacebo -
HELAS (warfarin vs aspirin), 2006   warfarinaspirinLow risk of bias -
WATCH (warfarin vs aspirin), 2009      NCTwarfarinaspirinsuggesting

beta-blockers

bisoprolol
CIBIS, 1994     bisoprololplaceboLow risk of bias suggesting
CIBIS II, 1999     bisoprololplaceboLow risk of bias suggesting
CIBIS II (elderly subgroup), 1999       Bisoprololplacebosuggesting
bucindolol
BEST, 2001    NCTbucindololplaceboLow risk of bias suggesting
Pollock, 1990   BucindololplaceboLow risk of bias -
Woodley, 1991   Bucindololplacebo -
Bristow, 1994   Bucindololplacebo -
MERIT-HF (elderly subgroup), 1999     Bucindololplacebosuggesting
carvedilol
ANZ-HeFT, 1997         carvedilolplaceboLow risk of bias negative
COPERNICUS, 2002     carvedilolplaceboLow risk of bias suggesting
CAPRICORN, 2001   carvedilolplaceboLow risk of bias suggesting
Metra, 1994   carvedilolplacebo -
Olsen, 1995     carvedilolplacebo -
Krum, 1995     carvedilolplacebo -
Bristow (MOCHA), 1996     carvedilolplaceboLow risk of bias -
Parker, 1996       carvedilolplaceboLow risk of bias negative
Colucci, 1996     carvedilolplaceboLow risk of bias -
Cohn, 1997     carvedilolplacebo -
Carvedilol U.S. Trials (elderly subgroup), 1996     Carvedilolplacebosuggesting
COPERNICUS (elderly subgroup), 2001     Carvedilolplacebosuggesting
CARMEN (carvedilol alone), 2004   carvedilolenalaprilnegative
COMET, 2003   carvedilolmetoprololLow risk of bias suggesting
metoprolol
MDC (Waagstein), 1993   metoprololplaceboLow risk of bias negative
MERIT-HF, 1999       metoprololplaceboLow risk of bias suggesting
Engelmeier, 1985   metoprololplacebo -
Fisher, 1994   metoprololplacebo -
Eichhorn, 1994   metoprololplacebo -
RESOLVD, 2000     metoprololplacebo -
BEST (elderly subgroup), 2001     Metoprololplacebonegative
nebivolol
Lechat, 1991   Nebivololplacebo -
Wisenbaugh, 1993   NebivololplaceboLow risk of bias negative
SENIORS, 2005     nebivololplaceboLow risk of bias -

BNP guided management

not classified
TIME CHF, 2009     BNP-guided managementcontrolRisk of bias negative
PRIMA     BNP-guided managementcontrolRisk of bias negative
PROTECT, 2009    NCTBNP-guided managementcontrol -
STARS-BNP, 2007   BNP-guided managementcontrolRisk of bias suggesting
BATTLESCARRED, 2009   BNP-guided managementcontrolRisk of bias negative
STARBRITE, 2007    NCTBNP-guided managementcontrol -
Troughton, 2000   BNP-guided managementcontrolRisk of bias suggesting

calcium channel blockers

not classified
De Vries, 1996     placeboLow risk of bias -
amlodipine
Packer, 1991   amlodipinecontrolLow risk of bias -
Smith, 1994     amlodipinecontrolLow risk of bias -
Udelson, 1996   amlodipinecontrolLow risk of bias -
Binkley, 1996   amlodipinecontrolLow risk of bias -
Ghali, 1997   amlodipinecontrolLow risk of bias -
PRAISE, 1996     amlodipineplaceboLow risk of bias negative
PRAISE II , 2000     AmlodipineplaceboLow risk of bias negative
diltiazem
Liao , 1998     DiltiazemplaceboExploratory suggesting
DiDi, 1996     diltiazemplaceboLow risk of bias negative
felodipine
VHeFT III, 1997     felodipineplaceboLow risk of bias negative
Kassis, 1987   felodipineplaceboLow risk of bias -
Littler, 1995   FelodipineplaceboLow risk of bias negative
Kassis, 1990   felodipineplaceboLow risk of bias -
Dunselman, 1990   felodipineenalaprilLow risk of bias -
De Vries, 1995     felodipineenalaprilLow risk of bias -
isradipine
Van den Toren, 1996     isradipineplaceboLow risk of bias -
mibefradil
MACH 1, 2000     mibefradilplaceboLow risk of bias suggesting
nicardipine
Gheorghiade, 1991   nicardipinecontrolLow risk of bias -
Abrams, 1993   nicardipinecontrolLow risk of bias -
nisoldipine
Gaudron, 1996   NisoldipineplaceboExploratory -
Rousseau, 1994   nisoldipineplaceboLow risk of bias -
Schofer, 1990   nisoldipinecaptoprilLow risk of bias -

cell-based therapies

not classified
Revive      -
POSEIDON, 2012      NCTMesenchymal stem cellsallogeneic mesenchymal stem cells -
Pokushalov (DOUBLON DIB), 2010   Bone marrow derived stem cellcontrol -
FOCUS-CCTRN, 2012      NCTBone marrow derived stem cellcontrol -
CUPID 2b, 2016      NCTBone marrow derived stem cellcontrol -
TOPCARE-CHD, 2006     Bone marrow mononuclear cellscontrol -
Hendrikx, 2006     Bone marrow mononuclear cellscontrol -
Yao, 2008       Bone marrow mononuclear cellscontrol -
Ang, 2008     Bone marrow mononuclear cellscontrol -
Patel, 2005     Bone marrow progenitor cellscontrol -
Manginas, 2007     Bone marrow progenitor cellscontrol -
Vrtovec, 2011      NCTBone marrow progenitor cellscontrol -
Vrtovec, 2013      NCTBone marrow progenitor cellscontrol -
Perin, 2012     Bone marrow progenitor cellscontrol -
SCIPIO, 2011        NCTCardiac stem cellscontrol -
C CURE, 2013        NCTCardiopoietic stem cellcontrol -
CADUCEUS, 2012      NCTCardiopoietic stem cellcontrol -
IMPACT-DCM, 2014    NCTixmyelocel-Tcontrol -
Catheter-DCM, 2014      NCTixmyelocel-Tcontrol -
CAuSMIC, 2005       myoblastscontrolnegative
SEISMIC, 2011     myoblastscontrolnegative
TAC-HFT, 2014      NCTStem cellscontrol -
INCL, 2015      NCTBone marrow derived stem cellplaceboLow risk of bias -
ABCD, 2010     Bone marrow derived stem cellplacebo -
FOCUS-HF, 2011      NCTBone marrow mononuclear cellsplacebonegative
CUPID, 2011       gene therapyplaceboExploratory -
ixCELL-DCM, 2016      NCTixmyelocel-Tplacebo -
MAGIC, 2001     myoblastsplacebonegative
MARVEL, 2011      NCTmyoblastsplacebonegative

cholesterol lowering intervention

atorvastatin
Wojnicz, 2006     atorvastatincontrolheart failurenegative
Yamada, 2007     atorvastatincontrolheart failurenegative