heart failure  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

aldosterone blockade

eplerenone
EPHESUS, 2003eplerenoneplaceboLow risk of bias suggesting
EMPHASIS-HF, 2010eplerenoneplaceboNCT00232180Low risk of bias suggesting
REMODEL ongoing eplerenoneplaceboNCT00082589Low risk of bias ongoing
Weir ongoing eplerenoneplaceboNCT00132093Low risk of bias ongoing
spironolactone
Cicoira, 2004spironolactonecontrol -
Cicoira, 2002spironolactonecontrolExploratory -
Ramires, 2000spironolactonecontrolExploratory -
RALES, 1998spironolactoneplaceboRisk of bias suggesting
Agostoni, 2005spironolactoneplaceboExploratory -
Mottram, 2004spironolactoneplaceboLow risk of bias -
Macdonald, 2004spironolactoneplaceboLow risk of bias -
Yee, 2001spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001spironolactoneplaceboLow risk of bias -
Farquharson, 2000spironolactoneplaceboLow risk of bias -
MacFadyen, 1997spironolactoneplaceboLow risk of bias -
PIE II ongoing spironolactoneplaceboNCT00123955Low risk of bias ongoing
Han, 1994spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000aldactonefurosemideExploratory -
Nouvel essai ongoing spironolactonespironolactoneNCT00125437Exploratory ongoing
Mauersberger, 1985spironolactone+furosemidespironolactone+butizideExploratory -

angiotensin-Converting Enzyme Inhibitors

not classified
CASSIS (spirapril), 1995spiraprilplaceboLow risk of bias -
benazepril
McGany, 1991benazeprilcontrolnegative
Colfer, 1992benazeprilplaceboLow risk of bias negative
captopril
Magnani, 1986captoprilplaceboLow risk of bias -
Bussmann, 1987captoprilplaceboLow risk of bias negative
Captopril Digoxin Multicenter Research Group, 1988captoprilplaceboLow risk of bias negative
Barabino, 1991captoprilplaceboLow risk of bias suggesting
Munich MHFT (Kleber), 1992captoprilplaceboLow risk of bias negative
Magnani, 1990captoprilplaceboLow risk of bias -
CMRG, 1983captoprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995captoprilplaceboLow risk of bias -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboLow risk of bias -
Sogaard, 1994captoprilplaceboLow risk of bias -
Sharpe, 1988captoprilplaceboLow risk of bias -
Mortarino, 1990captoprilplaceboLow risk of bias -
packer, 1986captoprilenalaprilExploratory -
cilazapril
Drexler, 1989cilazaprilplaceboLow risk of bias negative
Dosseger, 1993cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group, 1995cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995cilazaprilcaptoprilLow risk of bias -
enalapril
Rucinska-b (enalapril), 1991enalaprilcontrolnegative
Enalapril CHF investigators, 1987enalaprilcontrolnegative
Rucinska-a (enalapril), 1991enalaprilcontrolnegative
SOLVD treatment, 1991enalaprilplaceboNCT00000516Low risk of bias suggesting
SOLVD prevention, 1992enalaprilplaceboNCT00000516Low risk of bias -
Cleland, 1985enalaprilplaceboLow risk of bias negative
CONSENSUS, 1987enalaprilplaceboLow risk of bias negative
Dickstein, 1991enalaprilplaceboLow risk of bias negative
Sharpe, 1984enalaprilplaceboLow risk of bias -
McGrath, 1985enalaprilplaceboLow risk of bias -
Chrysant, 1985enalaprilplaceboLow risk of bias -
CASSIS (enalapril), 1995enalaprilplaceboLow risk of bias -
NETWORK (2.5 bid vs 10 bid), 1998enalaprilenalaprilLow risk of bias -
NETWORK (5 bid vs 10 bid), 1998enalaprilenalaprilLow risk of bias -
V-HeFT II, 1991enalaprilhydralazine+ISDNLow risk of bias -
fosinopril
Brown, 1995fosinoprilplaceboLow risk of bias -
FEST (Erhardt), 1996fosinoprilplaceboLow risk of bias -
lisinopril
Zwehl, 1990lisinoprilcontrolnegative
Giles, 1990lisinoprilcontrolnegative
Rucinska-c (lisinopril), 1000lisinoprilcontrolnegative
Gilbert, 1993lisinoprilplaceboLow risk of bias negative
International Study Group (Lewis), 1989lisinoprilplaceboLow risk of bias -
ATLAS, 1999lisinoprillisinoprilLow risk of bias -
perindopril
Lechat, 1993perindoprilplaceboLow risk of bias negative
PEP CHF, 2006perindoprilplaceboLow risk of bias negative
quinapril
Uprichard-a, 1994controlnegative
Uprichard-b, 1994controlnegative
Uprichard-c, 1994controlnegative
Riegger, 1990placeboLow risk of bias negative
Northridge, 1991placeboLow risk of bias negative
Rieger, 1991placeboLow risk of bias negative
Nussberger, 1994placeboLow risk of bias -
Quinapril Heart Failure Trial Investigators, 1993placeboLow risk of bias -
ramipril
Swedberg, 1991ramiprilcontrolnegative
Maass-a, 1991ramiprilplacebonegative
Gordon, 1991ramiprilplaceboLow risk of bias suggesting
Maass-b, 1991ramiprilplaceboLow risk of bias negative
Maass-c, 1991ramiprilplaceboLow risk of bias negative
Lemarie, 1992ramiprilplaceboLow risk of bias negative
Gundersen, 1994ramiprilplaceboLow risk of bias -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
Hampton, 1998trandolaprilplaceboLow risk of bias -
TRACE, 1995trandolaprilplaceboLow risk of bias -

angiotensin-receptor blockers

not classified
PARAGON-HF ongoing LCZ696ValsartanNCT01920711 ongoing
ADEPT, 2001eprosartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
candesartan
ARCH-J, 2003candesartanplaceboLow risk of bias -
CHARM-Alternative, 2003candesartanplaceboLow risk of bias suggesting
Mitrovic et al., 2003candesartanplaceboLow risk of bias suggesting
SPICE, 2000candesartanplaceboLow risk of bias negative
STRETCH, 1999candesartanplaceboLow risk of bias -
CHARM preserved, 2003candesartanplaceboLow risk of bias -
CHARM-Added, 2003candesartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
RESOLVD association, 1999candesartan+ACE inhibitorACE inhibitor onlyExploratory negative
RESOLVD (candesartan alone), 1999candesartanenalaprilLow risk of bias negative
irbesartan
I-PRESERVE (McMurray), 2008ibesartanplaceboNCT00095238Low risk of bias negative
Tonkon et al., 2000irbesartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
losartan
NCT00090259 ongoing losartanlosartanNCT00090259Low risk of bias ongoing
HEAAL, 2009losartan 150mglosartan 50mgNCT00090259Low risk of bias suggesting
Losartan Phase III International, 1996losartanplaceboLow risk of bias suggesting
Losartan Phase III U.S., 1995losartanplaceboLow risk of bias negative
Hamroff et al., 1999losartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
ELITE, 1997losartancaptoprilLow risk of bias negative
ELITE II, 2000losartancaptoprilLow risk of bias -
Dickstein et al., 1995losartanenalaprilLow risk of bias -
Lang et al., 1997losartanenalaprilLow risk of bias -
Losartan phase II S, 1996losartanenalaprilLow risk of bias -
losartan phase II US, 1996losartanenalaprilLow risk of bias -
telmisartan
REPLACE, 2001telmisartanenalaprilLow risk of bias -
valsartan
VALIDD, 2007valsartanno valsartanNCT00170924Low risk of bias negative
Mazayev et al. (vs placebo), 1998valsartanplaceboLow risk of bias -
V-HeFT, 1999valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
Val-HeFT, 2001valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias suggesting
HEAVEN, 2002valsartanenalaprilLow risk of bias -
Mazayev et al. (vs lisinopril, 1998valsartanLisinoprilExploratory -

anti inflammatory drugs

not classified
ACCLAIM, 2008Celacade™ systemplaceboNCT00111969Low risk of bias negative

antiarrythmic drugs

amiodarone
EPAMSA, 1985amiodaroneno treatmentsuggesting
GESICA, 1994amiodaroneno treatmentsuggesting
Hamer, 1989amiodaroneplaceboLow risk of bias suggesting
Nicklas, 1991amiodaroneplaceboLow risk of bias negative
STATCHF, 1995amiodaroneplaceboLow risk of bias negative
AMIOVIRT, 2003amiodaroneICDnegative
dronedarone
ANDROMEDA, 2008dronedaroneplaceboNCT00543699Low risk of bias negative

antithrombotics

not classified
Barzizza (A+D), 1993placebo -
aspirin
WASH (aspirin), 2004aspirinno treatmentnegative
Barzizza (ASA), 1993aspirinplaceboExploratory -
clopidogrel
WATCH (clopidogrel vs aspirin) ongoing clopidogrelaspirinLow risk of bias ongoing
enoxaparin
THE-PRINCE (Kleber), 2003enoxaparinUFH -
rivaroxaban
COMMANDER HF ongoing rivaroxabanplaceboNCT01877915 ongoing
warfarin
WASH (warfarin), 2004warfarinno treatmentnegative
HELAS (warfarin vs placebo), 2006warfarinplaceboLow risk of bias -
Barzizza (warfarin), 1993warfarinplacebo -
HELAS (warfarin vs aspirin), 2006warfarinaspirinLow risk of bias -
WATCH (warfarin vs aspirin), 2009warfarinaspirinNCT00007683suggesting

beta-blockers

bisoprolol
CIBIS, 1994bisoprololplaceboLow risk of bias suggesting
CIBIS II, 1999bisoprololplaceboLow risk of bias suggesting
CIBIS II (elderly subgroup), 1999Bisoprololplacebosuggesting
bucindolol
BEST, 2001bucindololplaceboNCT00000560Low risk of bias suggesting
Pollock, 1990BucindololplaceboLow risk of bias -
Woodley, 1991Bucindololplacebo -
Bristow, 1994Bucindololplacebo -
MERIT-HF (elderly subgroup), 1999Bucindololplacebosuggesting
carvedilol
ANZ-HeFT, 1997carvedilolplaceboLow risk of bias negative
COPERNICUS, 2002carvedilolplaceboLow risk of bias suggesting
CAPRICORN, 2001carvedilolplaceboLow risk of bias suggesting
Metra, 1994carvedilolplacebo -
Olsen, 1995carvedilolplacebo -
Krum, 1995carvedilolplacebo -
Bristow (MOCHA), 1996carvedilolplaceboLow risk of bias -
Parker, 1996carvedilolplaceboLow risk of bias negative
Colucci, 1996carvedilolplaceboLow risk of bias -
Cohn, 1997carvedilolplacebo -
Carvedilol U.S. Trials (elderly subgroup), 1996Carvedilolplacebosuggesting
COPERNICUS (elderly subgroup), 2001Carvedilolplacebosuggesting
CARMEN (carvedilol alone), 2004carvedilolenalaprilnegative
CARMEN (carvedilol+enalapril), 2004 ongoing carvedilol+enalaprilenalapril ongoing
COMET, 2003carvedilolmetoprololLow risk of bias suggesting
metoprolol
MDC (Waagstein), 1993metoprololplaceboLow risk of bias negative
MERIT-HF, 1999metoprololplaceboLow risk of bias suggesting
Engelmeier, 1985metoprololplacebo -
Fisher, 1994metoprololplacebo -
Eichhorn, 1994metoprololplacebo -
RESOLVD, 2000metoprololplacebo -
BEST (elderly subgroup), 2001Metoprololplacebonegative
nebivolol
Lechat, 1991Nebivololplacebo -
Wisenbaugh, 1993NebivololplaceboLow risk of bias negative
SENIORS, 2005nebivololplaceboLow risk of bias -

BNP guided management

not classified
TIME CHF, 2009BNP-guided managementcontrolRisk of bias negative
PRIMABNP-guided managementcontrolRisk of bias negative
PROTECT, 2009BNP-guided managementcontrolNCT00351390 -
STARS-BNP, 2007BNP-guided managementcontrolRisk of bias suggesting
BATTLESCARRED, 2009BNP-guided managementcontrolANZCTR12605000735651Risk of bias negative
STARBRITE, 2007BNP-guided managementcontrolNCT00484770 -
Troughton, 2000BNP-guided managementcontrolRisk of bias suggesting
BASEL ongoing BNP-guided managementcontrolNCT00130611 ongoing
van Kraaij ongoing BNP-guided managementcontrolNCT00149422Risk of bias ongoing
RABBIT ongoing BNP-guided managementcontrolNCT00206856 ongoing

calcium channel blockers

not classified
De Vries, 1996placeboLow risk of bias -
amlodipine
Packer, 1991amlodipinecontrolLow risk of bias -
Smith, 1994amlodipinecontrolLow risk of bias -
Udelson, 1996amlodipinecontrolLow risk of bias -
Binkley, 1996amlodipinecontrolLow risk of bias -
Ghali, 1997amlodipinecontrolLow risk of bias -
PRAISE, 1996amlodipineplaceboLow risk of bias negative
PRAISE II , 2000AmlodipineplaceboLow risk of bias negative
diltiazem
Liao , 1998DiltiazemplaceboExploratory suggesting
DiDi, 1996diltiazemplaceboLow risk of bias negative
felodipine
VHeFT III, 1997felodipineplaceboLow risk of bias negative
Kassis, 1987felodipineplaceboLow risk of bias -
Littler, 1995FelodipineplaceboLow risk of bias negative
Kassis, 1990felodipineplaceboLow risk of bias -
Dunselman, 1990felodipineenalaprilLow risk of bias -
De Vries, 1995felodipineenalaprilLow risk of bias -
isradipine
Van den Toren, 1996isradipineplaceboLow risk of bias -
mibefradil
MACH 1, 2000mibefradilplaceboLow risk of bias suggesting
nicardipine
Gheorghiade, 1991nicardipinecontrolLow risk of bias -
Abrams, 1993nicardipinecontrolLow risk of bias -
nisoldipine
Gaudron, 1996NisoldipineplaceboExploratory -
Rousseau, 1994nisoldipineplaceboLow risk of bias -
Schofer, 1990nisoldipinecaptoprilLow risk of bias -

cell-based therapies

not classified
Revive -
POSEIDON, 2012Mesenchymal stem cellsallogeneic mesenchymal stem cellsNCT01087996 -
ESCAPE ongoing controlNCT00841958 ongoing
BC-14-001-02 ongoing controlNCT02438306 ongoing
Pokushalov (DOUBLON DIB), 2010Bone marrow derived stem cellcontrol -
FOCUS-CCTRN, 2012Bone marrow derived stem cellcontrolNCT00824005 -
CUPID 2b, 2016Bone marrow derived stem cellcontrolNCT01643330 -
TOPCARE-CHD, 2006Bone marrow mononuclear cellscontrol NCT00289822 -
Hendrikx, 2006Bone marrow mononuclear cellscontrol -
Yao, 2008Bone marrow mononuclear cellscontrol -
Ang, 2008Bone marrow mononuclear cellscontrol -
Patel, 2005Bone marrow progenitor cellscontrol -
Manginas, 2007Bone marrow progenitor cellscontrol -
Vrtovec, 2011Bone marrow progenitor cellscontrolNCT00629018 -
Vrtovec, 2013Bone marrow progenitor cellscontrolNCT01350310 -
Perin, 2012Bone marrow progenitor cellscontrol -
SCIPIO, 2011Cardiac stem cellscontrolNCT00474461 -
C CURE, 2013Cardiopoietic stem cellcontrolNCT00810238 -
CADUCEUS, 2012Cardiopoietic stem cellcontrolNCT00893360 -
IMPACT-DCM, 2014ixmyelocel-TcontrolNCT00765518 -
Catheter-DCM, 2014ixmyelocel-TcontrolNCT01020968 -
CAuSMIC, 2005myoblastscontrolnegative
SEISMIC, 2011myoblastscontrolnegative
TAC-HFT, 2014Stem cellscontrolNCT00768066 -
CMMo/MD/2013 ongoing placeboNCT02033278 ongoing
INCL, 2015Bone marrow derived stem cellplaceboNCT00333827Low risk of bias -
ABCD, 2010Bone marrow derived stem cellplacebo -
FOCUS-HF, 2011Bone marrow mononuclear cellsplaceboNCT00203203.negative
CUPID, 2011gene therapyplaceboExploratory -
ixCELL-DCM, 2016ixmyelocel-TplaceboNCT01670981 -
MAGIC, 2001myoblastsplacebonegative
MARVEL, 2011myoblastsplaceboNCT00526253 negative
C41750/3100 ongoing Bone marrow derived stem cellshamNCT02032004 ongoing
REMEDIUM ongoing Repetitive stem cell administrationSingle stem cell administrationNCT02248532 ongoing

cholesterol lowering intervention

atorvastatin
Wojnicz, 2006atorvastatincontrolheart failurenegative
Yamada, 2007atorvastatincontrolheart failurenegative
Strey, 2005atorvastatinplaceboheart failure -
Sola, 2006atorvastatinplaceboheart failureLow risk of bias negative
cerivastatin
Laufs, 2004cerivastatinplaceboheart failureLow risk of bias -
rosuvastatin
CORONA, 2007rosuvastatinplaceboheart failureNCT00206310Low risk of bias negative
Krum, 2007rosuvastatinplaceboheart failureLow risk of bias negative
GISSI-HF rosuvastatine, 2008rosuvastatinplaceboheart failureNCT00336336Low risk of bias negative
simvastatin
Hong, 2005simvastatincontrolheart failureRisk of bias negative
Node, 2003simvastatinplaceboheart failurenegative
Landmesser, 2005simvastatinezetimibeheart failure -

combined inhibition of ACE and neprilysin

not classified
PARADIGM-HF, 2014sacubitril/valsartanenalaprilNCT01035255 -

digitalis glycosides

digoxin
Fleg, 1982digoxinplacebonegative
Lee, 1982digoxinplaceboLow risk of bias negative
Taggart, 1983digoxinplaceboLow risk of bias negative
Captopril-Digoxin Multicenter Research Group (CDMRG), 1988digoxinplaceboLow risk of bias suggesting
German and Austrian Xamoterol Study, 1988digoxinplaceboLow risk of bias negative
Guyatt, 1988digoxinplaceboLow risk of bias negative
DiBianco, 1989digoxinplaceboLow risk of bias suggesting
Pugh, 1989digoxinplaceboLow risk of bias negative
Blackwood, 1990digoxinplaceboLow risk of bias negative
Radiance, 1993digoxinplaceboLow risk of bias suggesting
Proved, 1993digoxinplaceboLow risk of bias negative
DIMT, 1993digoxinplaceboLow risk of bias negative
Digitalis Investigation Group (DIG), 1997digoxinplaceboNCT00000476Low risk of bias suggesting

diuretics

not classified
Burr, 1977diuretic agentsplaceboLow risk of bias negative
Mathur, 1984furosemide placeboLow risk of bias -
Sherman, 1986piretanideplaceboLow risk of bias negative
TOPCAT, 2014spironolactoneplaceboNCT00094302Low risk of bias -
De jong, 1994various diureticsplaceboLow risk of bias negative
Myers, 1982various diureticsplaceboLow risk of bias negative
Walma, 1997various diureticsplaceboLow risk of bias suggesting
Richardson, 1987frusemide plus amiloridecaptoprilLow risk of bias negative
Haerer, 1989piretanidedigoxinLow risk of bias -
UNLOADUltrafiltrationDiureticsNCT00124137Exploratory -
Myers (copie de 7314), 1982placebo (diuretics withdrawal)various diureticsLow risk of bias -
amiloride
Cheitlin, 1991amilorideplaceboLow risk of bias -
eplerenone
EMPHASIS-HF, 2010eplerenoneplaceboNCT00232180Low risk of bias suggesting
EPHESUS, 2003eplerenoneplaceboLow risk of bias suggesting
REMODEL ongoing eplerenoneplaceboNCT00082589Low risk of bias ongoing
Weir ongoing eplerenoneplaceboNCT00132093Low risk of bias ongoing
furosemide
Boccanelli, 1986furosemidecaptoprilLow risk of bias negative
Cowley, 1986furosemidecaptoprilLow risk of bias -
hydrochlorothiazide
Nordrehaug, 1992hydrochlorothiazidebenazeprilLow risk of bias suggesting
Sievert, 1989hydrochlorothiazide+triamterenedigoxinLow risk of bias -
rolofylline
PROTECT-1rolofyllineplaceboNCT00328692 -
spironolactone
Cicoira, 2004spironolactonecontrol -
Cicoira, 2002spironolactonecontrolExploratory -
Ramires, 2000spironolactonecontrolExploratory -
RALES, 1998spironolactoneplaceboRisk of bias suggesting
Agostoni, 2005spironolactoneplaceboExploratory -
Mottram, 2004spironolactoneplaceboLow risk of bias -
Macdonald, 2004spironolactoneplaceboLow risk of bias -
Yee, 2001spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001spironolactoneplaceboLow risk of bias -
Farquharson, 2000spironolactoneplaceboLow risk of bias -
MacFadyen, 1997spironolactoneplaceboLow risk of bias -
Barr, 1995spironolactoneplaceboLow risk of bias -
PIE II ongoing spironolactoneplaceboNCT00123955Low risk of bias ongoing
Han, 1994spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000aldactonefurosemideExploratory -
Dalhstrom, 1986furosemide + spironolactoneprenalterolLow risk of bias negative
Mauersberger, 1985spironolactone+furosemidespironolactone+butizideExploratory -

Exercise Therapy

not classified
HEARTS ongoing Resistance and Aerobic Trainingcontrol ongoing
HF-ACTION, 2008structured exercise trainingcontrolNCT00047437Risk of bias negative
Patwala, 2009structured exercise trainingcontrolExploratory -
Exercise Therapy
Belardinelli et al, 1999Exercise trainingcontrol -
Dubach et al, 1997Exercise trainingcontrol -
Giannuzzi et al, 1997Exercise trainingcontrol -
Hambrecht et al, 1995Exercise trainingcontrol -
Kiilavuori et al, 2000Exercise trainingcontrol -
McKelvie et al, 2002Exercise trainingcontrol -
Zanelli et al, 1997Exercise trainingcontrol -
Wielenga et al, 1999Exercise trainingcontrol -
Willenheimer et al, 1998Exercise trainingcontrol -
ExTraMATCH, 2004Exercise trainingcontrol -

HR-slowing agents

ivabradine
SHIFT, 2010ivabradineplaceboISRCTN70429960Low risk of bias suggesting
BEAUTIFUL, 2008ivabradine 15mgplaceboNCT00143507Low risk of bias negative

increasing hemoglobin concentration

not classified
Palazzuoli, 2006beta-erythropoietinplaceboLow risk of bias negative
FAIR-HF (Anker), 2009ferric carboxymaltoseplaceboLow risk of bias -
taspoglutide
STAMINA-HeFT (Ghali), 2008darbepoetin alfaplaceboNCT00049985Low risk of bias negative
van Veldhuisen, 2007darbepoetin alfaplaceboNCT00086086Low risk of bias