acute heart failure

     

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Trial Studied trt Control trt patientstagsNCTROB Result

atrial natriuretic peptide

not classified
TRUE-AHF ongoing UlaritideNCT01661634 ongoing
nesiritide
NSGET (comparative trial), 2000nesiritidecontrolLow risk of bias -
NSGET (efficacy trial), 2000nesiritideplaceboLow risk of bias negative
VMAC (intravenous neseritide), 2002nesiritideplaceboNCT00083772Low risk of bias -
PRECEDENT, 2002nesiritidedobutamineNCT00270400Exploratory -
VMAC (24h), 2002nesiritidenitroglycerinNCT00083772Risk of bias negative

calcium sensitiser

levosimendan
REVIVE II, 2013levosimendanplaceboNCT00048425Exploratory -
REVIVE-I, 2003levosimendanplaceboExploratory -
RUSSLAN, 2002levosimendanplaceboExploratory -
SURVIVE, 2007levosimendandobutamineNCT00348504Low risk of bias negative
CASINOlevosimendandobutamineLow risk of bias -
LIDO, 2002levosimendandobutamineExploratory -

diuretics

not classified
PARSiFAL ongoing BAY1067197placeboNCT02040233 ongoing
Reno-Defend 1 ongoing SLV320placeboNCT00744341 ongoing
S320.2.002 ongoing SLV320placeboNCT00160134 ongoing
rolofylline
PROTECT, 2010rolofyllineplaceboNCT00328692Low risk of bias negative
REACH UP ongoing rolofyllineplaceboNCT00443690 ongoing
PROTECT-2 ongoing rolofyllineplaceboNCT00354458 ongoing
PROTECT-1 ongoing rolofyllineplaceboNCT00328692 ongoing
7418-503 ongoing rolofyllineplaceboNCT00729222 ongoing
2007_806 ongoing rolofyllineplaceboNCT00652782 ongoing
tonapofylline
TRIDENT-1 ongoing tonapofyllineplaceboNCT00709865 ongoing
POSEIDON ongoing tonapofyllineplaceboNCT00745316 ongoing

endothelin receptor antagonist

not classified
VERITAS 1 ongoing tezosentan NCT00525707 ongoing
VERITAS 2 ongoing tezosentanNCT00524433 ongoing
VERITAS I, 2006tezosentanplaceboNCT00525707Low risk of bias -
VERITAS II, 2007tezosentanplaceboNCT00525707Low risk of bias -
RITZ-5, 2003tezosentanplaceboExploratory -
RITZ 4 importé, 2003tezosentanplaceboLow risk of bias -
nesiritide
NSGET (comparative trial), 2000nesiritidecontrolLow risk of bias -
NSGET (efficacy trial), 2000nesiritideplaceboLow risk of bias negative
PROACTION, 2003nesiritideplaceboLow risk of bias negative
BNP-CARDS, 2007nesiritideplaceboNCT00186329Exploratory -
FUSION 2, 2008nesiritideplaceboNCT00091520Low risk of bias -
ASCEND-HF, 2011nesiritideplaceboNCT00475852Low risk of bias negative
VMAC (intravenous neseritide), 2002nesiritideplaceboNCT00083772Low risk of bias -
PRECEDENT, 2002nesiritidedobutamineNCT00270400Exploratory -
VMAC (24h), 2002nesiritidenitroglycerinNCT00083772Risk of bias negative
FUSION 1, 2004nesiritidestandard careNCT00270361Low risk of bias -

new drug under development

not classified
UNLOAD -
COMPOSE EARLY ongoing Cinaciguat NCT01064037 ongoing
COMPOSE 1 ongoing Cinaciguat NCT01065077 ongoing
COMPOSE 2 ongoing Cinaciguat NCT01067859 ongoing
NCT00559650 ongoing Cinaciguat NCT00559650 ongoing
PRONTO ongoing Clevidipine NCT00803634 ongoing
CONVERT-H ongoing Conivaptan NCT00843986 ongoing
087-CL-071 ongoing ConivaptanNCT00057356 ongoing
Debio 0614-202 ongoing Istaroxime NCT00838253 ongoing
HORIZON-HF ongoing Istaroxime NCT00616161 ongoing
CVie2015002 ongoing istaroxime NCT02617446 ongoing
BALANCE ongoing Lixivaptan NCT00578695 ongoing
VERITAS 1 ongoing tezosentan NCT00525707 ongoing
VERITAS 2 ongoing tezosentanNCT00524433 ongoing
BLAST-AHF ongoing TRV027 NCT01966601 ongoing
TRUE-AHF ongoing UlaritideNCT01661634 ongoing
CARRESS-HFultrafiltration -
AVOID HFultrafiltrationNCT01474200 -
05-025 ongoing ZP120 NCT00283361 ongoing
B-CONVINCED, 2009beta-blockade continuationdiscontinuationNCT00162565). -
PARSiFAL ongoing BAY1067197placeboNCT02040233 ongoing
Reno-Defend 1 ongoing SLV320placeboNCT00744341 ongoing
S320.2.002 ongoing SLV320placeboNCT00160134 ongoing
levosimendan
REVIVE II, 2013levosimendanplaceboNCT00048425Exploratory -
REVIVE-I, 2003levosimendanplaceboExploratory -
RUSSLAN, 2002levosimendanplaceboExploratory -
SURVIVE, 2007levosimendandobutamineNCT00348504Low risk of bias negative
CASINOlevosimendandobutamineLow risk of bias -
LIDO, 2002levosimendandobutamineExploratory -
nesiritide
NSGET (comparative trial), 2000nesiritidecontrolLow risk of bias -
NSGET (efficacy trial), 2000nesiritideplaceboLow risk of bias negative
PROACTION, 2003nesiritideplaceboLow risk of bias negative
BNP-CARDS, 2007nesiritideplaceboNCT00186329Exploratory -
FUSION 2, 2008nesiritideplaceboNCT00091520Low risk of bias -
ASCEND-HF, 2011nesiritideplaceboNCT00475852Low risk of bias negative
VMAC (intravenous neseritide), 2002nesiritideplaceboNCT00083772Low risk of bias -
PRECEDENT, 2002nesiritidedobutamineNCT00270400Exploratory -
VMAC (24h), 2002nesiritidenitroglycerinNCT00083772Risk of bias negative
FUSION 1, 2004nesiritidestandard careNCT00270361Low risk of bias -
rolofylline
PROTECT, 2010rolofyllineplaceboNCT00328692Low risk of bias negative
REACH UP ongoing rolofyllineplaceboNCT00443690 ongoing
PROTECT-2 ongoing rolofyllineplaceboNCT00354458 ongoing
PROTECT-1 ongoing rolofyllineplaceboNCT00328692 ongoing
7418-503 ongoing rolofyllineplaceboNCT00729222 ongoing
2007_806 ongoing rolofyllineplaceboNCT00652782 ongoing
serelaxin
Pre-RELAX-AHF, 2009serelaxinplaceboNCT00520806Exploratory -
RELAX-AHF, 2013serelaxinplaceboNCT00520806 -
RELAX-AHF-2 ongoing serelaxinplaceboNCT01870778 ongoing
tonapofylline
TRIDENT-1 ongoing tonapofyllineplaceboNCT00709865 ongoing
POSEIDON ongoing tonapofyllineplaceboNCT00745316 ongoing

positive inotropic agent

not classified
Debio 0614-202 ongoing Istaroxime NCT00838253 ongoing
HORIZON-HF ongoing Istaroxime NCT00616161 ongoing
CVie2015002 ongoing istaroxime NCT02617446 ongoing

relaxin

serelaxin
Pre-RELAX-AHF, 2009serelaxinplaceboNCT00520806Exploratory -
RELAX-AHF, 2013serelaxinplaceboNCT00520806 -
RELAX-AHF-2 ongoing serelaxinplaceboNCT01870778 ongoing

ultrafiltration

not classified
UNLOAD -
CARRESS-HFultrafiltration -
AVOID HFultrafiltrationNCT01474200 -

vasodilators therapy

not classified
COMPOSE EARLY ongoing Cinaciguat NCT01064037 ongoing
COMPOSE 1 ongoing Cinaciguat NCT01065077 ongoing
COMPOSE 2 ongoing Cinaciguat NCT01067859 ongoing
NCT00559650 ongoing Cinaciguat NCT00559650 ongoing

vasopressin antagonist

not classified
CONVERT-H ongoing Conivaptan NCT00843986 ongoing
087-CL-071 ongoing ConivaptanNCT00057356 ongoing
BALANCE ongoing Lixivaptan NCT00578695 ongoing
tolvaptan
EVEREST Clinical Status , 2007tolvaptanplaceboNCT00071331 -
EVEREST Outcome, 2007tolvaptanplacebo -
Udelson, 2007tovalpanplaceboNCT00043758Exploratory suggesting