Taxanes

Docetaxel - Nab-paclitaxel - Paclitaxel      

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Trial Studied trt Control trt patientstagsNCTROB Result

advanced breast cancer (metastatic)

docetaxel
JCOG, 2005docetaxeldoxorubicin + cyclophosphamide 1st line Exploratory negative
Blohmer, 2010docetaxel + epirubicinepirubicin, cyclophosphamide 1st line Risk of bias negative
Rivera , 2008Weekly DocetaxelEvery three weeks Docetaxel -
Tabernero , 2004Weekly DocetaxelEvery three weeks Docetaxel -
Sedky , 2002Weekly DocetaxelEvery three weeks Docetaxel -
Willemse , 2007Weekly DocetaxelEvery three weeks Docetaxel -
Bontenbal, 2005docetaxel + doxorubicinfluorouracil, doxorubicin, cyclophosphamide 1st line Risk of bias suggesting
Bonneterre, 2004docetaxel + epirubicinfluorouracil, epirubicin, cyclophosphamideRisk of bias suggesting
TXT Group, 2002docetaxelfluorouracil, vinorelbine 2nd line previous anthracycline Exploratory suggesting
304 Study Group, 1999docetaxelmitomycin, vinblastine 2nd+ line previous anthracycline Risk of bias suggesting
Sjostrom, 1999docetaxelsequential methotrexate and 5-fluorouracil 2nd+ line previous anthracycline Exploratory suggesting
HERNATA, 2011docetaxel + trastuzumabvinorelbine, trastuzumab 1st line HER-2 positive Exploratory suggesting
nab-paclitaxel
Gradishar, 2009nab-paclitaxeldocetaxel 1st line NCT00274456Exploratory -
Roy, 2008nab-paclitaxel +gencotabinegencitabine 1st line NCT00110084 -
paclitaxel
Talbot, 2002pacclitaxelcapecitabineExploratory negative
TOG, 2005paclitaxelcisplatin, etoposideExploratory negative
ANZ TITG, 1999paclitaxelCMFP 1st line Risk of bias suggesting
ECOG E1193 (B), 2003paclitaxeldoxorubicinExploratory negative
EORTC 10923, 2000paclitaxeldoxorubicin 1st line Exploratory negative
UKCCCR AB01, 1997paclitaxel + epirubicinepirubicin, cyclophosphamide 1st line Exploratory suggesting
Gradishar , 2009Weekly PaclitaxelEvery three weeks DocetaxelExploratory negative
Fountzilas , 2008Weekly PaclitaxelEvery three weeks Docetaxelnegative
Khoo , 2006split doseEvery three weeks Paclitaxel not previously treated by anthracycline negative
CLGB 9840 (Seidman), 2008Weekly PaclitaxelEvery three weeks Paclitaxelsuggesting
Frasci , 2006Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Frasci , 2005Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Sikov , 2002Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Jassem, 2001paclitaxel + doxorubicinfluorouracil, doxorubicin, cyclophosphamide 1st line Exploratory suggesting
CECOG BM1, 2005gemcitabine, epirubicin, paclitaxelfluorouracil, epirubicin, cyclophosphamide 1st line Exploratory suggesting
Dieras, 1995paclitaxelmitomycinExploratory negative

lung cancer (metastatic)

docetaxel
TAX 317 (Shepherd) 100mg/m2, 2000docetaxel -
TAX 320 100mg/m2, 2000docetaxel -
DISTAl 01 (Gridelli) , 2004weekly docetaxel3-weekly docetaxel -
Camps weekly docetaxel3-weekly docetaxel -
Schuette weekly docetaxel3-weekly docetaxel -
Gervais weekly docetaxel3-weekly docetaxel -
Lai weekly docetaxel3-weekly docetaxel -
Chen weekly docetaxel3-weekly docetaxel -
Esteban, 2003paclitaxel 80mg/m2m2docetaxel 36 mg/ -