Taxanes

Docetaxel - Nab-paclitaxel - Paclitaxel      

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Trial Studied trt Control trt patientstagsROB Trial result

advanced breast cancer (metastatic)

docetaxel
JCOG, 2005   docetaxeldoxorubicin + cyclophosphamide 1st line Exploratory -
Blohmer, 2010   docetaxel + epirubicinepirubicin, cyclophosphamide 1st line Risk of bias -
Rivera , 2008   Weekly DocetaxelEvery three weeks Docetaxel -
Tabernero , 2004   Weekly DocetaxelEvery three weeks Docetaxel -
Sedky , 2002   Weekly DocetaxelEvery three weeks Docetaxel -
Willemse , 2007   Weekly DocetaxelEvery three weeks Docetaxel -
Bontenbal, 2005   docetaxel + doxorubicinfluorouracil, doxorubicin, cyclophosphamide 1st line Risk of bias -
Bonneterre, 2004   docetaxel + epirubicinfluorouracil, epirubicin, cyclophosphamideRisk of bias -
TXT Group, 2002   docetaxelfluorouracil, vinorelbine 2nd line previous anthracycline Exploratory -
304 Study Group, 1999   docetaxelmitomycin, vinblastine 2nd+ line previous anthracycline Risk of bias -
Sjostrom, 1999   docetaxelsequential methotrexate and 5-fluorouracil 2nd+ line previous anthracycline Exploratory -
HERNATA, 2011   docetaxel + trastuzumabvinorelbine, trastuzumab 1st line HER-2 positive Exploratory -
nab-paclitaxel
Gradishar, 2009              NCTnab-paclitaxeldocetaxel 1st line Exploratory -
Roy, 2008        NCTnab-paclitaxel +gencotabinegencitabine 1st line -
paclitaxel
Talbot, 2002   pacclitaxelcapecitabineExploratory -
TOG, 2005   paclitaxelcisplatin, etoposideExploratory -
ANZ TITG, 1999   paclitaxelCMFP 1st line Risk of bias -
ECOG E1193 (B), 2003   paclitaxeldoxorubicinExploratory -
EORTC 10923, 2000   paclitaxeldoxorubicin 1st line Exploratory -
UKCCCR AB01, 1997   paclitaxel + epirubicinepirubicin, cyclophosphamide 1st line Exploratory -
Gradishar , 2009   Weekly PaclitaxelEvery three weeks DocetaxelExploratory negative
Fountzilas , 2008   Weekly PaclitaxelEvery three weeks Docetaxelnegative
Khoo , 2006   split doseEvery three weeks Paclitaxel not previously treated by anthracycline negative
CLGB 9840 (Seidman), 2008   Weekly PaclitaxelEvery three weeks Paclitaxelsuggesting
Frasci , 2006   Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Frasci , 2005   Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Sikov , 2002   Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Jassem, 2001   paclitaxel + doxorubicinfluorouracil, doxorubicin, cyclophosphamide 1st line Exploratory -
CECOG BM1, 2005   gemcitabine, epirubicin, paclitaxelfluorouracil, epirubicin, cyclophosphamide 1st line Exploratory -
Dieras, 1995   paclitaxelmitomycinExploratory -

lung cancer (metastatic)

docetaxel
TAX 317 (Shepherd) 100mg/m2, 2000       docetaxel -
TAX 320 100mg/m2, 2000     docetaxel -
DISTAl 01 (Gridelli) , 2004     weekly docetaxel3-weekly docetaxel -
Camps     weekly docetaxel3-weekly docetaxel -
Schuette     weekly docetaxel3-weekly docetaxel -
Gervais     weekly docetaxel3-weekly docetaxel -
Lai     weekly docetaxel3-weekly docetaxel -
Chen     weekly docetaxel3-weekly docetaxel -
Esteban, 2003     paclitaxel 80mg/m2m2docetaxel 36 mg/ -