Taxanes

Docetaxel - Nab-paclitaxel - Paclitaxel      

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Trial Studied trt Control trt patientstagsROB Trial result

advanced breast cancer (metastatic)

docetaxel
JCOG, 2005   docetaxeldoxorubicin + cyclophosphamide 1st line Exploratory negative
Blohmer, 2010   docetaxel + epirubicinepirubicin, cyclophosphamide 1st line Risk of bias negative
Rivera , 2008   Weekly DocetaxelEvery three weeks Docetaxel -
Tabernero , 2004   Weekly DocetaxelEvery three weeks Docetaxel -
Sedky , 2002   Weekly DocetaxelEvery three weeks Docetaxel -
Willemse , 2007   Weekly DocetaxelEvery three weeks Docetaxel -
Bontenbal, 2005   docetaxel + doxorubicinfluorouracil, doxorubicin, cyclophosphamide 1st line Risk of bias suggesting
Bonneterre, 2004   docetaxel + epirubicinfluorouracil, epirubicin, cyclophosphamideRisk of bias suggesting
TXT Group, 2002   docetaxelfluorouracil, vinorelbine 2nd line previous anthracycline Exploratory suggesting
304 Study Group, 1999   docetaxelmitomycin, vinblastine 2nd+ line previous anthracycline Risk of bias suggesting
Sjostrom, 1999   docetaxelsequential methotrexate and 5-fluorouracil 2nd+ line previous anthracycline Exploratory suggesting
HERNATA, 2011   docetaxel + trastuzumabvinorelbine, trastuzumab 1st line HER-2 positive Exploratory suggesting
nab-paclitaxel
Gradishar, 2009              NCTnab-paclitaxeldocetaxel 1st line Exploratory -
Roy, 2008        NCTnab-paclitaxel +gencotabinegencitabine 1st line -
paclitaxel
Talbot, 2002   pacclitaxelcapecitabineExploratory negative
TOG, 2005   paclitaxelcisplatin, etoposideExploratory negative
ANZ TITG, 1999   paclitaxelCMFP 1st line Risk of bias suggesting
ECOG E1193 (B), 2003   paclitaxeldoxorubicinExploratory negative
EORTC 10923, 2000   paclitaxeldoxorubicin 1st line Exploratory negative
UKCCCR AB01, 1997   paclitaxel + epirubicinepirubicin, cyclophosphamide 1st line Exploratory suggesting
Gradishar , 2009   Weekly PaclitaxelEvery three weeks DocetaxelExploratory negative
Fountzilas , 2008   Weekly PaclitaxelEvery three weeks Docetaxelnegative
Khoo , 2006   split doseEvery three weeks Paclitaxel not previously treated by anthracycline negative
CLGB 9840 (Seidman), 2008   Weekly PaclitaxelEvery three weeks Paclitaxelsuggesting
Frasci , 2006   Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Frasci , 2005   Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Sikov , 2002   Weekly PaclitaxelEvery three weeks Paclitaxelnegative
Jassem, 2001   paclitaxel + doxorubicinfluorouracil, doxorubicin, cyclophosphamide 1st line Exploratory suggesting
CECOG BM1, 2005   gemcitabine, epirubicin, paclitaxelfluorouracil, epirubicin, cyclophosphamide 1st line Exploratory suggesting
Dieras, 1995   paclitaxelmitomycinExploratory negative

lung cancer (metastatic)

docetaxel
TAX 317 (Shepherd) 100mg/m2, 2000       docetaxel -
TAX 320 100mg/m2, 2000     docetaxel -
DISTAl 01 (Gridelli) , 2004     weekly docetaxel3-weekly docetaxel -
Camps     weekly docetaxel3-weekly docetaxel -
Schuette     weekly docetaxel3-weekly docetaxel -
Gervais     weekly docetaxel3-weekly docetaxel -
Lai     weekly docetaxel3-weekly docetaxel -
Chen     weekly docetaxel3-weekly docetaxel -
Esteban, 2003     paclitaxel 80mg/m2m2docetaxel 36 mg/ -