multi target TKI  

Apitolisib - Axitinib - Cabozantinib - Dovitinib - Pazopanib - Sorafenib - Sunitinib - Tivozanib      

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Trial Studied trt Control trt patientstagsNCTROB Result

advanced breast cancer (metastatic)

lapatinib
Johnston (EGF30008) , 2009lapatinib + letrozoleletrozole alone HR positive NCT00073528Low risk of bias conclusive
Di Leo, 2008lapatinib + paclitaxelpaclitaxel alone 1st line NCT00075270Low risk of bias negative
paclitaxel
ICORG 11-10 ongoing lapatinib + paclitaxel + trastuzumabpaclitaxel + trastuzumabmetastatic NCT01526369Risk of bias ongoing
EGF104535 ongoing lapatinib + paclitaxelpaclitaxel alonemetastaticNCT00281658Low risk of bias ongoing
sorafenib
Baselga, 2012sorafenib + capecitabinecapecitabine alone HER-2 negative Low risk of bias suggesting
RESILIENCE, 2013 ongoing sorafenib + capecitabinecapecitabine alone ongoing
Schwartzberg, 2013sorafenib + gemcitabine or capecitabinegemcitabine or capecitabine alone 2nd line HER-2 negative NCT00493636Exploratory suggesting
Gradishar, 2013sorafenib + paclitaxelpaclitaxel alone 1st line HER-2 negative Low risk of bias negative

renal-cell carcinoma (advanced)

apitolisib
Powles, 2014apitolisibeverolimus -
axitinib
AXIS (Rini), 2011axitinibsorafenibNCT00678392suggesting
Qin, 2012axitinibsorafenib -
cabozantinib
METEOR, 2015cabozantinibeverolimus after VEGFR-targeted therapy failure 2nd line NCT01865747Risk of bias suggesting
CABOSUN, 2017cabozantinibsunitinibfirst-line therapy in patients with intermediate- or poor-risk 1st line NCT01835158Exploratory suggesting
dovitinib
GOLDdovitinibsorafenibNCT01223027Risk of bias negative
pazopanib
Sternberg, 2010pazopanibplaceboLow risk of bias suggesting
VEG105192, 2010pazopanibplaceboNCT00334282suggesting
COMPARZ, 2013pazopanibsunitinibNCT00720941negative
sorafenib
Escudier, 2009sorafenibinterferon alphaExploratory negative
TARGET, 2007sorafenibplaceboNCT00073307Low risk of bias suggesting
Ratain, 2006sorafenibplaceboExploratory -
sunitinib
Motzer, 2007sunitinibinterferon alphaNCT00083889suggesting
SWITCHsunitinibsorafenibNCT00732914 -
tivozanib
TIVO-1, 2013tivozanibsorafenibNCT01030783suggesting