multi target TKI

Apitolisib - Axitinib - Cabozantinib - Dovitinib - Pazopanib - Sorafenib - Sunitinib - Tivozanib      

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Trial Studied trt Control trt patientstagsNCTROB Result

advanced breast cancer (metastatic)

lapatinib
Johnston (EGF30008) , 2009lapatinib + letrozoleletrozole alone HR positive NCT00073528Low risk of bias conclusive
Di Leo, 2008lapatinib + paclitaxelpaclitaxel alone 1st line NCT00075270Low risk of bias negative
paclitaxel
ICORG 11-10 ongoing lapatinib + paclitaxel + trastuzumabpaclitaxel + trastuzumabmetastatic NCT01526369 ongoing
EGF104535 ongoing lapatinib + paclitaxelpaclitaxel alonemetastaticNCT00281658 ongoing
sorafenib
Baselga, 2012sorafenib + capecitabinecapecitabine alone HER-2 negative Exploratory suggesting
RESILIENCE, 2013 ongoing sorafenib + capecitabinecapecitabine alone ongoing
Schwartzberg, 2013sorafenib + gemcitabine or capecitabinegemcitabine or capecitabine alone 2nd line HER-2 negative NCT00493636Exploratory suggesting
Gradishar, 2013sorafenib + paclitaxelpaclitaxel alone 1st line HER-2 negative Exploratory negative

renal-cell carcinoma (advanced)

apitolisib
Powles, 2014apitolisibeverolimus -
axitinib
AXIS (Rini), 2011axitinibsorafenibNCT00678392suggesting
Qin, 2012axitinibsorafenib -
cabozantinib
METEOR, 2015cabozantinibeverolimus after VEGFR-targeted therapy failure 2nd line NCT01865747Risk of bias suggesting
CABOSUN, 2017cabozantinibsunitinibfirst-line therapy in patients with intermediate- or poor-risk 1st line NCT01835158Exploratory suggesting
dovitinib
GOLDdovitinibsorafenibNCT01223027negative
pazopanib
Sternberg, 2010pazopanibplacebosuggesting
VEG105192, 2010pazopanibplaceboNCT00334282suggesting
COMPARZ, 2013pazopanibsunitinibNCT00720941negative
sorafenib
Escudier, 2009sorafenibinterferon alphaExploratory negative
TARGET, 2007sorafenibplaceboNCT00073307Low risk of bias suggesting
Ratain, 2006sorafenibplaceboExploratory -
sunitinib
Motzer, 2007sunitinibinterferon alphaNCT00083889suggesting
SWITCHsunitinibsorafenibNCT00732914 -
tivozanib
TIVO-1, 2013tivozanibsorafenibNCT01030783suggesting