CDK (cyclin-dependent kinase) inhibitor

Abemaciclib - Palbociclib - Ribociclib      

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Trial Studied trt Control trt patientstagsROB Trial result

advanced breast cancer (metastatic)

abemaciclib
MONARCH 3, 2017        NCTAbemaciclib +nsAInsAI 1st line HER-2 negative HR positive postmenopausal Low risk of bias conclusive
palbociclib
PALOMA 3, 2015            NCTpalbociclib + fulvestrantfulvestrant alone2nd line 2nd line HER-2 negative HR positive Low risk of bias conclusive
PALOMA-2, 2016      NCTpalbociclib + letrozoleletrozole alonefirst line 1st line HER-2 negative HR positive postmenopausal Low risk of bias conclusive
PALOMA 1/TRIO-18, 2015      NCTpalbociclib + letrozoleletrozole alone 1st line HER-2 negative HR positive postmenopausal Exploratory suggesting
ribociclib
MONALEESA-2, 2016        NCTribociclib (LEE011) + letrozoleletrozole alonefirst line 1st line HER-2 negative HR positive postmenopausal Low risk of bias conclusive

lung cancer (metastatic)

abemaciclib
JUNIPER, 2018      NCTabemacicliberlotinib2nd lineRisk of bias remark