aromatase inhibitors

Aminoglutethimide - Anastrozole - Exemestane - Fadrozole - Formestane - Letrozole      

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Trial Studied trt Control trt patientstagsROB Trial resultobjective response (ORR)clinical benefit

advanced breast cancer (metastatic)

aminoglutethimide
Mercer, 1993   aminoglutethimidehydrocortisonenegative41%10%
Canney, 1988   aminoglutethimidemedroxyprogesterone acetatesuggesting27%7%
Garcia-Giralt, 1992   aminoglutethimidemedroxyprogesterone acetatenegative17%4%
Samonis, 1994   aminoglutethimidemedroxyprogesterone acetatenegative-13%-3%
Lundgren, 1989   aminoglutethimidemegestrol acetatenegative-15%-8%
Russell, 1997   aminoglutethimidemegestrol acetatenegative -79%
Alonso-Munoz, 1988   aminoglutethimidetamoxifennegative20%12%
Gale, 1994   aminoglutethimidetamoxifennegative -37%-12%
Ingle, 1986   aminoglutethimide + tamoxifentamoxifennegative 24%-13%
Powles, 1984   combination of hormone therapiestamoxifennegative -29%-18%
anastrozole
Mauriac, 2003   anastrozolefulvestrantnegative16%6%
Buzdar a, 1996   anastrozolemegestrol acetatenegative -2%-4%
TARGET (Bonneterre), 2001   anastrozoletamoxifensuggesting-7%-9%
Milla-Santos, 2003   anastrozoletamoxifennegative -25%-33%
exemestane
Chia, 2008   exemestanefulvestrantnegative8%0%
Kaufmann, 2000   exemestanemegestrol acetatenegative -17%-8%
Paridaens, 2003   exemestanetamoxifennegative -59%-26%
fadrozole
Bezwoda, 1998   fadrozolemegestrol acetatenegative-8%-26%
Buzdar b, 1996   fadrozolemegestrol acetatenegative 45%-1%
Buzdar c, 1996   fadrozolemegestrol acetatenegative -14%10%
Thuerlimann, 1996   fadrozoletamoxifennegative39%6%
Falkson, 1996   fadrozoletamoxifennegative-6%
formestane
Kleeberg, 1997   formestaneanastrozolenegative-44%17%
Thuerlimann, 1997   formestanemegestrol acetatenegative-1%-13%
Freue, 2000   formestanemegestrol acetatesuggesting24%
Perez Carrion, 1994   formestanetamoxifennegative12%10%
letrozole
Gershanovich, 1998   letrozoleaminoglutethimidenegative-36%-19%
Rose, 2003   letrozoleanastrozolenegative -35%-15%
Goss, 2007   letrozoleatamestane + toremifenenegative-15%-4%
Tominaga, 2003   letrozolefadrozolenegative -58%-30%
Buzdar, 2001   letrozolemegestrol acetatesuggesting4%-12%
Dombernowsky, 1998   letrozolemegestrol acetatenegative-30%-8%
Mourisden, 2001   letrozoletamoxifennegative -33%-22%