ALK inhibitors

Alectinib - Brigatinib - Ceritinib - Crizotinib      

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Trial Studied trt Control trt patientstagsNCTROB Result

lung cancer (metastatic)

alectinib
ALEX, 2017alectinibcrizotinibNCT02075840Risk of bias conclusive
YO29449 ongoing alectinibcrizotinibNCT02838420 ongoing
MO29750 ongoing alectinibpremetrexed or docetaxelNCT02604342 ongoing
brigatinib
ALTA-1L ongoing brigatinibcrizotinibNCT02737501 ongoing
ceritinib
ASCEND-4, 2017ceritinibchemotherapyNCT01828099 -
CLDK378A2303 ongoing ceritinibpemetrexed or docetaxelNCT01828112 ongoing
crizotinib
Shaw, 2013crizotinibchemotherapyNCT00932893suggesting
PROFILE 1014, 2014crizotinibchemotherapyNCT01154140suggesting
A8081029 ongoing crizotinibchemotherapyNCT01639001 ongoing
E4512 ongoing crizotinibplaceboNCT02201992 ongoing