Head and neck cancer

     

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Trial Studied trt Control trt patientstagsNCTROB Result

immune checkpoint inhibition

durvalumab
Hawk ongoing durvalumabstandard treatment2L PD-L1 positive 2nd line PD-L1 positive NCT02207530 ongoing
durvalumab + tremelimumab
Condor ongoing durvalumab +/- tremelimumabstandard treatment2L PD-L1 positive 2nd line PD-L1 positive NCT02319044 ongoing
Kestrel ongoing durvalumab +/- tremelimumabstandard treatment1L 1st line NCT02551159 ongoing
Eagle ongoing durvalumab +/- tremelimumabstandard treatment2L 2nd line NCT02369874 ongoing
nivolumab
Checkmate-141, 2016nivolumabstandard treatment2L 2nd line platinum failure NCT02105636Risk of bias conclusive
Checkmate-651 ongoing nivolumab + ipilumabstandard treatment1L 1st line NCT02741570 ongoing
pembrolizumab
KEYNOTE-048 ongoing pembrolizumabCetuximab + Platinum + 5FU1L 1st line NCT02358031 ongoing
KEYNOTE-040pembrolizumabstandard treatment2L 2nd line NCT02252042Risk of bias negative
Keynote 147 ongoing pembrolizumab +/- acalabrutinibstandard treatment>2L 2nd line 2nd+ line NCT02454179 ongoing

Induction chemotherapy

not classified
Richard (IGR-65), 1974CT with methotrexateno induction chemotherapynegative
Fazekas (RTOG 6801), 1980CT with methotrexateno induction chemotherapynegative
National Health Research Institutes, Taiwan ongoing MEPFLno induction chemotherapyNCT00201396 ongoing
Toohill (MCW-2), 1987PFno induction chemotherapynegative
Lewin (SHNG-85), 1997PFno induction chemotherapynegative
Paccagnella (GSTTC-86 ), 1994PFno induction chemotherapynegative
Domenge (GETTEC neo1), 1995PFno induction chemotherapynegative
Domenge (GETTEC), 2000PFno induction chemotherapynegative
Dalley (AHNTG), 1995PFno induction chemotherapynegative
Tejedor (Las Palmas), 1992PFno induction chemotherapynegative
Gedouin (Rennes-87), 1996PFno induction chemotherapynegative
Di Blasio (Parma), 1994PFno induction chemotherapynegative
Depondt (CFHNS), 1993PFno induction chemotherapynegative
Volling (Cologne), 1994PFno induction chemotherapynegative
Hasegawa (HNAP-02), 1996PFno induction chemotherapy -
BNH 003PFno induction chemotherapynegative
RTOG 91-11 (I+RT vs RT alone), 2003PFno induction chemotherapysuggesting
Hareyama, 2002PFno induction chemotherapy -
Licitra, 2003PFno induction chemotherapyNCT00002747negative
EORTC 24844PFno induction chemotherapyEORTC-24844negative
Hitt (PF), 2005 ongoing PFno induction chemotherapy ongoing
HNCP, 1987polyCT with platinno induction chemotherapynegative
Schuller (SWOG 8006), 1988polyCT with platinno induction chemotherapynegative
Szpirglas (Pitié-81 ), 1988polyCT with platinno induction chemotherapynegative
Carugati (Buenos Aires ), 1988polyCT with platinno induction chemotherapynegative
Mazeron (Créteil-82), 1992polyCT with platinno induction chemotherapynegative
Brunin (HNCGIC02), 1989polyCT with platinno induction chemotherapynegative
Salvajoli (AC Camargo), 1992polyCT with platinno induction chemotherapynegative
Jaulerry Trial 2 (Curie)(HNCGIC03), 1992polyCT with platinno induction chemotherapynegative
Maipang (Songkla), 1995polyCT with platinno induction chemotherapynegative
Kohno, 2000polyCT with platinno induction chemotherapynegative
Jortay (EORTC 24771), 1990polyCT without platinno induction chemotherapynegative
Richard (EORTC 78-OCP), 1991polyCT without platinno induction chemotherapynegative
Holoye (MCW-1), 1985polyCT without platinno induction chemotherapynegative
DeCIDE (IRB 13362B, Chicago) ongoing TPFno induction chemotherapyNCT00117572 ongoing
SWOG-S0427 ongoing TPFno induction chemotherapyNCT00268372 ongoing
XRP6976F_2501 ongoing TPFno induction chemotherapyNCT00357149 ongoing
Hitt (TPF), 2005 ongoing TPFno induction chemotherapy ongoing
AVENTIS-DFCI-04006 ongoing TPFno induction chemotherapyNCT00095875 ongoing
XRP6976F/2503 ongoing TPFPFNCT00261703 ongoing
Dana-Farber Cancer Institute (Posner) importé ongoing TPFPFNCT00004214 ongoing
Chauvergne, 1988polyCT with platincisplatinnegative
De Andres, 1995carboplatin, 5FUPFnegative
Clark (Dana farber cancer Institute 83-084), 1988PBMPFnegative
Fonseca, 2005TPPFnegative
EORTC 24971 (TAX 323), 2006TPFPFNCT00003888suggesting
Posner (TAX324), 2007TPFPFNCT00273546suggesting
GORTEC 2000-01TPFPFNCT00169182suggesting
TAX324 (Larynx preservation subset), 2007TPFPFNCT00273546 -
Hitt docetaxel, 2005 ongoing TPFPF ongoing
Prévost, 2005VP16 based CTPFnegative
Fonseca, 1997PF with leucovorinPF without leucovorinnegative
GETTEC, 1998induction PFsurgerysuggesting
Veterans Affairs, 1998induction PFsurgerysuggesting
EORTC 24891, 1996induction PFsurgeryEORTC 24891suggesting
paclitaxel
Hitt paclitaxel, 2005paclitaxel based CTPFsuggesting