early breast cancer

     

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Trial Studied trt Control trt patientstagsNCTROB Result

HER2 inhibitors

pertuzumab
AphinitypertuzumabplaceboNCT01358877 -
trastuzumab
NSABP B31, 2005trastuzumabcontrolsuggesting
BCIRG006, 2013trastuzumabcontrolsuggesting
Buzdar, 2005trastuzumabcontrolsuggesting
FinHer, 2006trastuzumabcontrolnegative
HERA, 2005trastuzumabcontrolsuggesting
N9831, 2005trastuzumabcontrolsuggesting
NOAH, 2010trastuzumabcontrolnegative
PACS-04, 2009trastuzumabcontrolsuggesting
N9831 (1)trastuzumabcontrolsuggesting
N9831 (2)trastuzumabcontrolsuggesting
FinHer (1)trastuzumabcontrolnegative

monoclonal antibody

not classified
HERA (BIG 01-01) 2-years, 2005trastuzumabNCT00045032 -
HERA (BIG 01-01) 1-year, 2005trastuzumabcontrolNCT00045032Risk of bias suggesting
NCCTG N9831(C vs A)trastuzumabcontrolsuggesting
NSABP B-31trastuzumab during chemotherapycontrolsuggesting