early breast cancer

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

HER2 inhibitors

pertuzumab
Aphinity    NCTpertuzumabplaceboLow risk of bias -
trastuzumab
NSABP B31, 2005   trastuzumabcontrol -
BCIRG006, 2013   trastuzumabcontrol -
Buzdar, 2005   trastuzumabcontrol -
FinHer, 2006   trastuzumabcontrol -
HERA, 2005   trastuzumabcontrol -
N9831, 2005   trastuzumabcontrol -
NOAH, 2010   trastuzumabcontrol -
PACS-04, 2009   trastuzumabcontrol -
N9831 (1)   trastuzumabcontrol -
N9831 (2)   trastuzumabcontrol -
FinHer (1)   trastuzumabcontrol -

monoclonal antibody

not classified
HERA (BIG 01-01) 2-years, 2005    NCTtrastuzumab -
HERA (BIG 01-01) 1-year, 2005    NCTtrastuzumabcontrolRisk of bias suggesting
NCCTG N9831(C vs A)   trastuzumabcontrolsuggesting
NSABP B-31   trastuzumab during chemotherapycontrolsuggesting