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cholesterol lowering intervention in cardiovascular prevention for patient with related disease, clinical trials results

atorvastatin versus placebo
SALTIRE, 2005
atorvastatin 80mg daily
versus
placebo
patients with calcific aortic stenosisdouble blind
Follow-up duration: 25 mo (7-36)
ezetimibe versus placebo (on top statins)
Enhance, 2008
ezetimibe 10mg + simvastatin daily
versus
simvastatin 80mg daily
patients with familial hypercholesterolemiadouble blind
Follow-up duration: 24 months
ezetimibe+simvastatin versus placebo
SEAS, 2008
NCT00092677
simvastatin 40mg plus ezetimibe 10 mg daily
versus
placebo
patients with mild-tomoderate, asymptomatic aortic stenosisdouble blind
Follow-up duration: 52.2 mo
Europe
fluvastatin versus placebo
ALERT, 2003
fluvastatin 40 mg daily
versus
placebo
renal transplant recipients with total cholesterol 4.0-9.0 mmol/Ldouble-blind
Follow-up duration: 5.1 years
Belgium, Denmark, Finland, Germany, Norway,
pravastatin versus placebo
PREVEND IT, 2004
pravastatin 40 mg daily
versus
placebo
subjects with microalbuminuriadouble blind
Follow-up duration: 46 months
the Netherlands
rosuvastatin versus placebo
ASTRONOMER, 2010
ISRCTN 32424163
rosuvastatin 40 mg daily
versus
placebo
asymptomatic patients with mild to moderate aortic stenosis and no clinical indications for cholesterol loweringdouble blind
Follow-up duration: 3.5 y

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