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antiplatelets drug in thrombosis prevention for orthopedic surgery , clinical trials results

Aspirin versus no treatment
Pasteyer, 1977
Aspirin 1000mg daily + Hep
versus
control (Hep alone)
Elective orthopaedic surgery
Follow-up duration: 2 weeks
Rocha, 1986
Aspirin 250mg or 1000mg daily
versus
control (combination of heparin plus dihydroergotamine)
total hip replacementopen
Follow-up duration: 1 weeks
Aspirin versus placebo
Zekert-I , 1974
Aspirin 1500mg daily
versus
placebo
patients undergoing surgery of hip-joint proximal fracturesdouble-blind
Powers , 1976
A1300
versus
placebo
traumatic orthopaedic surgery
Erfurt-B , 1979
A1500
versus
placebo
traumatic orthopaedic surgerydouble-blind
Stockholm-I, 1975
Aspirin 2000mg daily
versus
placebo
elective surgery of the hipdouble blind
Follow-up duration: 2 weeks
Harris-I, 1977
Aspirin 1200mg daily
versus
placebo
patients over 40 years of age, who had undergone total hip replacementdouble-blind
Follow-up duration: 1 weeks
McKenna-I, 1980
Aspirin 975mg or 3900mg daily
versus
placebo
total knee replacementdouble-blind
Follow-up duration: 2 weeks
Sautter, 1983
Aspirin 900mg daily + sulfinpyrazone
versus
placebo
patient with total hip replacement
Follow-up duration: 3 weeks
McBride, 1983
A1800+Dipyridamole
versus
placebo
Elective orthopaedic surgery
Follow-up duration: 1 weeks
aspirin + dipyridamol versus no treatment
Morris-B , 1977
Aspirin 900 mg daily + dipyridamole
versus
control
elderly patients with hip fracturesopen
Lyon-I, 1975
Aspirin 1500 mg daily + Dipyridamole
versus
control
Elective orthopaedic surgery
Follow-up duration: 2 weeks
aspirin + dipyridamol versus placebo
Encke-II , 1976
Aspirin 1500mg daily, Aspirin 990mg daily + dipyridamol
versus
placebo
patients with abdominal operations double-blind
Hamburg, 1976
A+Dipyridamole,A1000
versus
placebo
Elective orthopaedic surgery
Follow-up duration: 3 weeks
dipyridamol versus no treatment
Morris-A , 1977
dipyridamole
versus
control
elderly patients with hip fracturesopen
Flurbiprofen versus no treatment
Mocris-C , 1977
Flurbiprofen
versus
control
elderly patients with hip fracturesopen
Hydroxychloroquine versus no treatment
Massachusetts-I , 1981
Aspirin 1200mg daily, Aspirin 1200mg daily + hydroxychloroquine 300 mg b.i.d.
versus
control
patients with upper femoral fractures open
Hydroxychloroquine versus placebo
Danish-A , 1976
Hydroxychloroquine sulphate
versus
placebo
patients with fractures of the hip, pelvis, or thoracolumbar spinedouble-blind
Danish-B , 1976
Hydroxychloroquine sulphate
versus
placebo
patients with fractures of the hip, pelvis, or thoracolumbar spine
Massachusetts-II, 1976
Hydroxychloroquine 600mg daily
versus
placebo
fractures or orthopaedic operations involving the skeleton between the knee and the pelvis
Follow-up duration: 3 weeks
Cooke, 1977
Hydroxychloroquine
versus
placebo
elective surgery on the hipdouble-blind
Follow-up duration: 2 weeks
Hume-A, 1977
Hydroxychloroquine
versus
placebo
total hip replacement
Follow-up duration: 2 weeks
Stockholm-II, 1981
Hydroxychloroquine
versus
placebo
total hip replacement
Follow-up duration: 2 weeks
RA233 versus placebo
Wood , 1973
RA233; Aspirin 600mg daily +RA233
versus
placebo
traumatic orthopaedic surgery
Ticlopidine versus placebo
McKenna-II, 1983
Ticlopidine
versus
placebo
Elective orthopaedic surgery
Follow-up duration: 2 weeks
Lyon-II, 3000
Ticlopidine
versus
placebo
Elective orthopaedic surgery
Follow-up duration: 3 weeks
Gardecki, 3000
Ticlopidine
versus
placebo
Elective orthopaedic surgery
Follow-up duration: 2 weeks
UFH versus no treatment
Bergqvist , 1979
UFH twice daily for 5 days
versus
no treatment
elective orthopedic surgery
Bergqvist, 1979
UFH twice daily for 5 days
versus
no treatment
traumatic orthopedic surgery
Dechavanne, 1974
UFH 3 times daily for 10 days
versus
no treatment
elective orthopedic surgery
Dechavanne, 1975
UFH 3 times daily for 10 days
versus
no treatment
elective orthopedic surgery
Galasko , 1976
UFH twice daily (duration unknown)
versus
no treatment
traumatic orthopedic surgery
Gallus , 1973
UFH 3 times daily for A
versus
no treatment
traumatic orthopedic surgery
Mannucci , 1976
UFH 3 times daily for 7 days
versus
no treatment
elective orthopedic surgery
Morris, 1974
UFH twice daily for 10 days
versus
no treatment
elective orthopedic surgery
Morris , 1977
UFH 3 times daily for 10 days
versus
no treatment
traumatic orthopedic surgery
VTCSG, 1975
UFH twice daily for 10 days
versus
no treatment
elective orthopedic surgery
Welin-Berger, 1982
UFH twice daily for 7 days
versus
no treatment
elective orthopedic surgery
UFH versus placebo
Abraham-Inpijn , 1975
UFH twice daily for 8 days
versus
placebo
elective orthopedic surgery
Hampson, 1974
UFH 3 times daily for 7- 10 days
versus
placebo
elective orthopedic surgery
Lahnborg, 1980
UFH twice daily for 10 days
versus
placebo
traumatic orthopedic surgery
Moskovitz, 1978
UFH 3 times daily for 7 days
versus
placebo
traumatic orthopedic surgery
Moskovitz, 1978
UFH 3 times daily for 7 days
versus
placebo
elective orthopedic surgery
Svend-Hansen, 1981
UFH 3 times daily for 14 days
versus
placebo
traumatic orthopedic surgery
Williams , 1978
UFH twice daily for 14 days
versus
placebo
elective orthopedic surgery
Xabregas , 1977
UFH twice daily for 14 days
versus
placebo
traumatic orthopedic surgery

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