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Drug eluting stent in coronary artery disease for acute myocardial infarction, clinical trials results

drug-eluting stents versus bare-metal stent
DEDICATION, 2008
NCT00192868
DES currently used with or without distal protection
versus
BMS with or without distal protection
patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction open
Follow-up duration: 8 mo (15 mo, 3y)
Denmark.
PASEO, 2009
paclitaxel-eluting stents and sirolimus-eluting stents
versus
bare metal stent
patients with ST-elevation myocardial infarction within 12 hours from symptom onsetopen
Follow-up duration: 4.3 years
Genous stent versus bare-metal stent
GENIUS-STEMI, 2009
endothelial progenitor cell capture stent
versus
cobalt chromium stent
patients with ST-elevation myocardial infarctionNA
Follow-up duration: 6 months
paclitaxel eluting stent versus bare-metal stent
HAAMU-STENT, 2006
Taxus Express
versus
Bare-metal-stent
AMI - STEMI patients undergoing PCIopen
Follow-up duration: 12 months
Finland
HORIZONS-AMI Stent, 2008
paclitaxel-eluting stents (Taxus)
versus
BMS (Express)
ST-elevation myocardial infarctionopen
Follow-up duration: 1 year
PASSION, 2006
ISRCTN65027270
Taxus Express2
versus
Express2 or Liberté
Myocardial Infarction with ST-Segment Elevationopen
Follow-up duration: 12 months (5y)
The Netherlands
sirolimus eluting stent versus bare-metal stent
DEBATER (SES vs BMS), 2009
sirolimus-eluting stents
versus
bare-metal stents
patients undergoing PCI for STEMI withon 12 hours
Follow-up duration: 1 y
Díaz de la Llera, 2007
sirolimus-eluting stents
versus
uncoated stents
primary percutaneous coronary intervention for acute myocardial infarction with ST-segment elevationopen
Follow-up duration: 1y
Spain
MISSION, 2008
ISRCTN62825862
Cypher
versus
Vision
primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (<9h)single-blind
Follow-up duration: 12 months
the Netherlands
SESAMI, 2007
NCT00288210
Cypher
versus
BX stent, Cordis
AMIopen
Follow-up duration: 12 months
Italy
TYPHOON, 2006
NCT00232830
Cypher or CypherSelect
versus
any commerciallyavailable uncoated stent
AMIopen
Follow-up duration: 12 months
Worldwide (15 countries)
sirolimus eluting stent versus paclitaxel eluting stent
PROSIT, 2006
SES Cordis
versus
PES Boston Scientific
AMI or persistent ischaemia 12-24hopen
Follow-up duration: 1 year
Korea
SORT OUT II, 2008
NCT00388934
Cypher stent
versus
Taxus stent(Boston Scientific Corp)
Unselected patients (included ST-segment elevation myocardial infarction (STEMI), non-STEMI or unstable angina pectoris, and stable angina)open
Denmark.
zotarolimus eluting stent versus paclitaxel eluting stent
ZEST AMI (vs PES), 2009
NCT00422565
zotarolimus-eluting stent (Endeavor)
versus
paclitaxel-eluting stent (Taxus Liberté)
Acute Myocardial Infarction Patients (STEMI)requiring primary angioplasty with symptom onset <= 12 hours open
Follow-up duration: 1 year (mean)
Korea
zotarolimus eluting stent versus sirolimus eluting stent
SORT-OUT-3, 2010
NCT00660478
Zotarolimus-eluting stents
versus
sirolimus-eluting stents (SES)
Patients With Coronary Artery Disease undergoing PCI for any indication open
Follow-up duration: 9 months (18 mo,3yrs)
ZEST AMI (vs SES), 2009
NCT00422565
zotarolimus-eluting stent (Endeavor)
versus
sirolimus-eluting stents (Cypher)
Acute Myocardial Infarction Patients (STEMI)requiring primary angioplasty with symptom onset <= 12 hours open
Follow-up duration: 1 year (mean)
Korea

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