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pentasaccharide in thrombosis prevention for abdominal surgery , clinical trials results

fondaparinux versus enoxaparin
PEGASUS, 2005
once-daily subcutaneous injections of fondaparinux 2·5 mg started 6 h after surgery for 5–9 days
versus
once-daily subcutaneous injections of dalteparin 5000 units for 5–9 days (2500 units each, given 2 h before surgery and 12 h after the preoperative administration)
patients undergoing major abdominal surgerydouble blind
Follow-up duration: 10 days (30 days)
22 countries
fondaparinux versus placebo (on top intermittent pneumatic comp.)
APOLLO (Turpie), 2007
fondaparinux 2.5 mg s.c. for 5-9 days, starting 6-8 h postoperatively + intermittent pneumatic compression
versus
placebo s.c. for 5-9 days, starting 6-8 h postoperatively + intermittent pneumatic compression
Patients aged at least 40 years undergoing abdominal surgerydouble blind
Follow-up duration: 10 days
US

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