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myocardial revascularization in stable angina for multivessels disease, clinical trials results

balloon angioplasty versus CABG
EAST, 1994
NCT00000465
transluminal coronary angioplasty
versus
coronary-artery bypass grafting
patients with multivessels coronary artery diseaseopen
Follow-up duration: 3 y
USA
GABI, 1994
Percutaneous transluminal coronary angioplasty
versus
coronary-artery bypass grafting
patients with symptomatic multivessel coronary diseaseopen
Follow-up duration: 1 y
Germany
BARI, 1996
NCT00000462
PTCA
versus
CABG
Patients with multivessel disease open
Follow-up duration: 5.4 y
USA, Canada
RITA, 1993
percutaneous transluminal coronary angioplasty
versus
coronary artery bypass surgery
patients with one, two, or three diseased coronary arteriesopen
Follow-up duration: 2.5 y (6.5y)
UK
ERACI, 1992
Percutaneous transluminal coronary angioplasty
versus
coronary artery bypass grafting
patients with multivessel disease and lesions suitable for either form of therapyopen
Follow-up duration: 3.8 y
Argentina
Toulouse, 1992
PTCA
versus
CABG
patients with multivessels coronary artery diseaseopen
Follow-up duration: 2.8 y
France
CABRI, 1995
percutaneous transluminal coronary angioplasty
versus
coronary artery bypass grafting
patients with symptomatic multivessel coronary diseaseopen
Follow-up duration: 1 y
Europe
balloon angioplasty versus medical treatment
RITA 2, 1997
PTCA within 3 mo of the randomisation
versus
medical treatment
Angina leading to admission within 90days, previous Q wave MI, no previousPTCA, no left main stem diseaseopen
Follow-up duration: 7y
UK
ACME 2 (Folland), 1997
PTCA
versus
medical therapy
Stable angina, history of angina, MIwithin 3 months, exercise test with STdepression >3 mm, no previous PTCA; Stenosis >70% proximal two thirds,no main artery stenosis >50%, no 3vessel diseaseopen
Follow-up duration: 5y
PCI versus CABG
AWESOME, 2001
percutaneous coronary intervention
versus
coronary artery bypass graft
high-risk patients with medically refractory ischemia open
Follow-up duration: 5 years
US (Veterans Affairs Medical Centers)
PCI with drug-eluting stents versus CABG
FREEDOM, 2012
NCT00086450
percutaneous coronary stenting
versus
CABG
patients with diabetes and multivessel coronary artery diseaseopen
Follow-up duration: 3.8 yrs (median)
international
PCI with or without stent versus medical treatment
AVERT, 1995
angioplasty
versus
atorvastatin at 80 mg per day
Angina or asymptomatic, MI orunstable angina but not within 14 days,no triple vessel diseaseopen
Follow-up duration: 1.5y
Dakik, 1998
PTCA
versus
intensive medical therapy
stable survivors of AMIopen
Follow-up duration: 1y
MASS II, 2007
PCI
versus
medical therapy
patients with multivessel coronary artery disease with stable angina and preserved ventricular functionopen
Follow-up duration: 5y
Hambrecht, 2004
PCI
versus
12 months of exercise training (20 minutes of bicycle ergometry per day)
male patients aged 70 yearsopen
Follow-up duration: 1y
Bech, 2001
PTCA
versus
deferral of PTCA
patients with planned PTCA and no documented ischemia and with coronary pressure–derived fractional flow reserve >0.75open
Follow-up duration: 2y
stent versus CABG
ARTS, 2001
Palmaz-Schatz Crown/Cross flex (Cordis)
versus
Conventional CABG
Multi vessel disease with 2 or more de novo lesion in different major arteries Total occlusion < 1monthopen
Follow-up duration: 1 year
International
CARDia (PCI), 2008
ISRCTN19872154
PCI plus stenting (and routine abciximab)
versus
CABG
Patients with diabetes and symptomatic multivessel coronary artery disease or complex single-vessel disease. open
Follow-up duration: 1 y
UK, Ireland
ERACI II, 2003
Gianturco Robin II (Cook) Primary device
versus
Conventional CABG
multi vessel disease Angina CSS III-IV; no angina but large area of heart at risk; unstable =1 vessel to be treated Lesion>3.0mmopen
Follow-up duration: 30d, 1year
Argentinad
MASS II, 2007
PCI (73% stent)
versus
CABG
patients with multivessel coronary artery disease with stable angina and preserved ventricular functionopen
Follow-up duration: 5y (1y)
South America
Myoprotect, 2004
percutaneous transluminal coronary angioplasty/stent
versus
CABG
patients with symptomatic main-stem and main-stem-equivalent lesions with substantially increased risk for bypass surgeryopen
Follow-up duration: 1 year
Europe
SOS, 2002
NCT00475449
Stent
versus
CABG
multiple vessel disease Symptomatic 1 or more vessel suitable for stentingopen
Follow-up duration: 3 years
Canada, United Kingdom, Europe

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