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renin inhibitor in hypertension for all type of patients, clinical trials results

aliskiren versus hydrochlorothiazide
Schmieder (vs HCTZ), 2009
aliskiren 300 mg
versus
hydrochlorothiazide 25 mg
patients with essential hypertension double blind
Follow-up duration: 20 weeks
aliskiren versus losartan
ALLAY, 2009
NCT00219141
aliskiren 300 mg
versus
losartan 100 mg
patients with hypertension, increased ventricular wall thickness, and body mass index >25 kg/m2open
Follow-up duration: 9 months
aliskiren versus placebo
AVOID, 2008
NCT00097955
aliskiren (150 mg daily for 3 months, followed by an increase in dosage to 300 mg daily for another 3 months
versus
placebo
patients with hypertension and type 2 diabetes with nephropathydouble blind
Follow-up duration: 6 months
15 countries
aliskiren versus ramipril
Andersen, 2008
aliskiren 150 mg (up to 300mg) daily
versus
ramipril 5 mg (up to 10mg) daily
double blind
Follow-up duration: 26 weeks

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