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intensive blood pressure control in hypertension for all type of patients, clinical trials results

more intensive blood pressure lowering strategie versus less intensive blood pressure lowering strategie
PAST-BP, 2015

versus
Wei, 2013
BP <=140/90 mm Hg
versus
BP <=150/90 mm Hg
Chinese hypertensive patients older than 70 years
Follow-up duration: 4 years (mean)
China
SPS3, 2013
NCT00059306.
less than 130 mm Hg
versus
130-149 mm Hg
patients lived in North America, Latin America, and Spain and had recent, MRI-defined symptomatic lacunar infarctionsopen-label
HOMED-BP, 2012
tight control (<125/<80 mm Hg (TC)) of HBP
versus
usual control (125-134/80-84 mm Hg (UC))
with an untreated systolic/diastolic HBP of 135-179/85-119 mm Hg
Follow-up duration: 5.3 years (median)
VANLISH, 2010
strict blood pressure control (<140 mm Hg)
versus
moderate blood pressure control (> or =140 mm Hg to <150 mm Hg)
patients aged 70 to 84 years with isolated systolic hypertension (sitting blood pressure 160 to 199 mm Hg)open-label
Follow-up duration: 3.07 years (median)
JATOS, 2008
strict treatment to maintain systolic blood pressure below 140 mmHg
versus
mild treatment to maintain systolic blood pressure below 160 but at or above 140 mmHg
elderly hypertensive patients with essential hypertension (65-85 years old, with a pretreatment systolic blood pressure of above 160 mmHg)open-label
UKPDS-HDS, 1998
blood pressure of <150/85 mm Hg (with the use of an angiotensin converting enzyme inhibitor captopril or a beta blocker atenolol as main treatment)
versus
less tight control aiming at a blood pressure of <180/105 mm Hg
patients with type 2 diabetesopen-label
Follow-up duration: 8.4 years
UK
SPRINT, 2015
NCT01206062
target of 120 mm Hg
versus
target of 140 mm Hg
high-risk hypertensive adults 50 years of age and older with one additional cardiovascular risk factor or preexisting kidney diseaseopen
Cardio-Sis, 2009
NCT00421863
tighter control of systolic BP with a goal of <130 mm Hg
versus
usual control, with a goal of <140 mm Hg
nondiabetic patients with hypertension and with SBP of 150 mm Hg or higher confirmed at two different timesopen
Follow-up duration: 2 years
Italy
AASK, 2002
arterial pressure goal of 92 mm Hg or lower
versus
usual mean arterial pressure goal of 102 to 107 mm Hg/pj
African-Americans,with diastolic blood pressure higher than 94mmHg and a glomerular filtration rate between 20 and 65 ml/min per 1.73 m2open
Follow-up duration: (range 3-6.4y)
USA
ABCD target (H) , 2000
intensive treatment with a diastolic blood pressure goal of 75 mmHg
versus
moderate treatment with a diastolic blood pressure goal of 80-89 mmHg
diabetes patients with DBP >=90 mmHgopen
Follow-up duration: 5 year
ABCD target (N) , 2002
intensive treatment (diastolic blood pressure decrease of 10 mmHg below baseline DBP)
versus
moderate treatment (diastolic blood pressure goal of 80-89 mmHg)
diabetes patients with diastolic blood pressure between 80 and 89mmHgopen
HOT, 1994
less or equal than 85 mmHg, or less or equal than 80 mmHg
versus
less or equal than 90 mmHg
patients with diastolic blood pressure between 100 mmHg and 115 mmHgopen
Follow-up duration: 3.8 y
26 countries
REIN-2, 2005
intensified (systolic/diastolic <130/80 mm Hg) blood-pressure control
versus
conventional (diastolic <90 mm Hg) blood-pressure control
patients with non-diabetic proteinuric nephropathies receiving background treatment with the ACE inhibitor ramipril open
Follow-up duration: 36 months
MDRD, 1994
low target blood pressure (mean arterial pressure < 92 mm Hg)
versus
usual target blood pressure (mean arterial pressure < 107 mm Hg)
patients with predominantly nondiabetic kidney disease and a glomerular filtration rate of 13 to 55 mL/min per 1.73 m2open
Follow-up duration: 2.2 y
Toto, 1995
strict blood pressure control (DBP 65 to 80 mm Hg)
versus
usual blood pressure control (DBP 85 to 95 mm Hg)
non-diabetic patients (age 25 to 73) with long-standing hypertension (DBP > or = 95 mm Hg), chronic renal insufficiency (GFR < or = 70 m/min/1.73 m2) and a normal urine sediment open
ACCORD blood pressure, 2008
NCT00000620
intensive therapy, targeting a systolic pressure of less than 120 mm Hg
versus
standard therapy, targeting a systolic pressure of less than 140 mm Hg
patients with a median glycated hemoglobin level of 8.1% at high risk for cardiovascular eventsopen
Follow-up duration: 4.7y
USA, Canada

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