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intensive blood pressure control in hypertension for non diabetic patients, clinical trials results

more intensive blood pressure lowering strategie versus less intensive blood pressure lowering strategie
SPRINT, 2015
NCT01206062
target of 120 mm Hg
versus
target of 140 mm Hg
high-risk hypertensive adults 50 years of age and older with one additional cardiovascular risk factor or preexisting kidney diseaseopen
Cardio-Sis, 2009
NCT00421863
tighter control of systolic BP with a goal of <130 mm Hg
versus
usual control, with a goal of <140 mm Hg
nondiabetic patients with hypertension and with SBP of 150 mm Hg or higher confirmed at two different timesopen
Follow-up duration: 2 years
Italy
HOT, 1994
less or equal than 85 mmHg, or less or equal than 80 mmHg
versus
less or equal than 90 mmHg
patients with diastolic blood pressure between 100 mmHg and 115 mmHgopen
Follow-up duration: 3.8 y
26 countries
REIN-2, 2005
intensified (systolic/diastolic <130/80 mm Hg) blood-pressure control
versus
conventional (diastolic <90 mm Hg) blood-pressure control
patients with non-diabetic proteinuric nephropathies receiving background treatment with the ACE inhibitor ramipril open
Follow-up duration: 36 months
MDRD, 1994
low target blood pressure (mean arterial pressure < 92 mm Hg)
versus
usual target blood pressure (mean arterial pressure < 107 mm Hg)
patients with predominantly nondiabetic kidney disease and a glomerular filtration rate of 13 to 55 mL/min per 1.73 m2open
Follow-up duration: 2.2 y
Toto, 1995
strict blood pressure control (DBP 65 to 80 mm Hg)
versus
usual blood pressure control (DBP 85 to 95 mm Hg)
non-diabetic patients (age 25 to 73) with long-standing hypertension (DBP > or = 95 mm Hg), chronic renal insufficiency (GFR < or = 70 m/min/1.73 m2) and a normal urine sediment open

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