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cholesterol lowering intervention in cardiovascular prevention for elderly, clinical trials results

fluvastatin versus placebo
FLARE (elderly subgroup), 1999
Fluvastatin 80mg
versus
CAD requiring PCI, subgroup of age 65-80 ydouble blind
Follow-up duration: 0.8y
LIPS (elderly subgroup), 2002
Fluvastatin 80mg
versus
CAD requiring PCI, subgroup of age 65-80 ydouble blind
Follow-up duration: 3.9y
lovastatin versus placebo
CRISP 20mg, 1994
NCT00000477
lovastatin 20mg daily
versus
placebo
elderly (mean 71y) with low-density lipoprotein cholesterol levels greater than 4.1 and less than 5.7 mmol/L double blind
Follow-up duration: 1 years
Pravastatin versus placebo
CARE (elderly subgroup), 1998
Pravastatin 40mg
versus
MI 3–20 months, subgroup of age 65-75 ydouble blind
Follow-up duration: 5.0y
LIPID (elderly sub group), 2001
Pravastatin 40mg
versus
MI or unstable angina, subgroup of age 65-75 ydouble blind
Follow-up duration: 6.1y
PLAC I (elderly sub group), 1995
Pravastatin 40mg
versus
Angiographic CAD or recent MI, subgroup of age 65-75 ydouble blind
Follow-up duration: 2.3y
REGRESS (elderly subgroup), 1995
Pravastatin 40mg
versus
Angiographic CAD, subgroup of age 65-70 ydouble blind
Follow-up duration: 2.0y
pravastatin versus placebo
PROSPER, 2002
pravastatin 40mg daily
versus
placebo
men and women aged 70-82 years with a history of, or risk factors for, vascular diseasedouble blind
Follow-up duration: 3.2 years
Ecosse, Irelande, Pays bas
rosuvastatin versus placebo
JUPITER (elderly sub group), 2009
rosuvastatin 20mg daily
versus
placebo
healthy individuals aged >=70 years with normal LDL cholesterols but with CRP levels >=2.0 mg/dLdouble blind
Follow-up duration: double-blind
simvastatin versus placebo
4S (elderly subgroup), 1997
Simvastatin 20-40mg
versus
MI 6 months or stable angina, subgroup of age 65-70 ydouble blind
Follow-up duration: 5.4y
HPS (elderly subgroup), 2002
Simvastatin 40mg
versus
Vascular disease or diabetes, subgroup of age 65-80 ydouble blind
Follow-up duration: 5.0y

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