New P2Y12 Inhibitors

TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

cangrelor
CHAMPION-PLATFORM, 2009cangrelor up frontdelayed clopidogrelNegativeNCT00385138
CHAMPION-PCI, 2009cangrelor up frontclopidogrel up front Low risk of bias NegativeNCT00305162
elinogrel
ERASE-MI, 2009elinogrelplacebo Exploratory Negative
prasugrel
JUMBO-TIMI 26, 2005prasugrelclopidogrel Exploratory Negative
TRITON-TIMI 38, 2007prasugrelclopidogrel Low risk of bias Suggesting NCT00097591
ticagrelor
DISPERSE-2 (90mg), 2007ticagrelorclopidogrel Exploratory Negative
PLATO, 2009ticagrelorclopidogrel Low risk of bias SuggestingNCT00391872