new version V2017

myocardial revascularization

Coronary Artery Bypass - Coronary Artery Bypass Surgery      

TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

anistreplase
UNASEM, 1992anistreplaseplacebo Exploratory -
t-pa
Gold, 1987t-PAplacebo Exploratory -
Topol, 1988t-PAplacebo Exploratory Negative
Nicklas, 1989t-PAplacebo Exploratory Negative
Williams, 1990t-PAplacebo Exploratory Negative
Ardissino, 1990t-PAplacebo Exploratory Negative
van der Brand, 1991t-PAplacebo Exploratory Negative
Freeman, 1992t-PAplacebo Low risk of bias Negative
charbonnier, 1992t-PAplacebo Exploratory -
TIMI 3A, 1993t-PAplacebo Exploratory -
TIMI 3B, 1995t-PAplacebo Low risk of bias -

acute myocardial infarction

abciximab
Zorman, 2002Abciximabprimary interventionNegative
ERAMI (Mesquita Gabriel), 2003Abciximabprimary interventionNegative
REOMOBILE (Arntz), 2003Abciximabprimary interventionNegative
BRAVE (Kastrati), 2004Abciximab + reteplaseprimary intervention -
ReoPro-BRIDGING (Gyongyosi), 2004Abciximabprimary interventionNegative
Bellandi, 2006Abciximabprimary interventionNegative
FINESSE (combination-facilitated PCI), 2008Abciximab + reteplaseprimary interventionNegative NCT00046228
FINESSE (abciximab-facilitated PCI), 2008Abciximabprimary interventionNegativeNCT00046228
alteplase
LIMI (Vermeer), 1999alteplaseprimary interventionNegative
PACT (Ross,), 1999alteplaseprimary interventionNegative
anistreplase
TEAM 2, 1991anistreplasestreptokinase -
APSAC
AIMS, 1988APSACplaceboSuggesting
German Multicenter Trial, 1988APSACplaceboSuggesting
APSIM, 1989APSACcontrolNegative
ISIS III (SK/APSAC), 1992APSACstreptokinaseNegative
TEAM 3, 1992APSACt-PA -
drug-eluting stents
DEDICATION, 2008drug-eluting stentsbare-metal stent Risk of bias SuggestingNCT00192868
PASEO, 2009drug-eluting stentsbare-metal stent -
eptifibatide
INTAMI (Zeymer), 2005Eptifibatideprimary interventionNegative
lanoteplase
InTIME-II, 2000lanoteplaseaccelerated t-PANegative
paclitaxel
PASSION, 2006paclitaxel eluting stentbare-metal stent Risk of bias NegativeISRCTN65027270
HAAMU-STENT, 2006paclitaxel eluting stentbare-metal stent Exploratory Negative
HORIZONS-AMI Stent, 2008paclitaxel eluting stentbare-metal stentSuggesting
PCI
Jaksch, 1998primary stentingballoon angioplastySuggesting
GRAMI (Rodriguez), 1998primary stentingballoon angioplastyNegative
Zwolle 5 (Suryapranata), 1998primary stentingballoon angioplastySuggesting
FRESCO, 1998primary stentingballoon angioplasty -
stent-PAMI (Grines), 1999primary stentingballoon angioplastySuggesting
PASTA (Saito), 1999primary stentingballoon angioplastySuggesting
PRISAM (Kawashima), 1999primary stentingballoon angioplastyNegative
STENTIM-2 (Maillard), 2000primary stentingballoon angioplastyNegative
PRAGUE, 2000systematic PCI (+stent)no systematic PCINegative
STAT, 2001primary stentingaccelerated t-PA -
PSSAAMI (Scheller), 2001primary stentingballoon angioplastySuggesting
C-PORT, 2002primary PCIaccelerated t-PA -
CADILLAC abciximab., 2002primary stentingballoon angioplasty -
CADILLAC (no abciximab), 2002primary stentingballoon angioplasty -
STOPAMI 2, 2002primary stentingimmediate thrombolysis -
SIAM III, 2002systematic PCI (+stent)no systematic PCINegative
STOPAMI 3, 2004primary stentingballoon angioplasty -
GRACIA-1, 2004systematic PCI (+stent)no systematic PCI Risk of bias Negative
ZWOLLE 6, 2005primary stentingballoon angioplasty -
CAPITAL AMI, 2005systematic PCI (+stent)no systematic PCINegative
senior PAMI, 2005primary PCIThrombolysis Risk of bias SuggestingNCT00136929
WEST, 2006systematic PCI (+stent)no systematic PCINegative
primary angioplasty
O'Neill, 1986primary ballon angioplastyintracoronary streptokinase -
DeWood, 1989primary ballon angioplastyduteplase -
Gibbons, 1993primary ballon angioplastyduteplase -
Ribeiro, 1993primary ballon angioplastystreptokinase -
Zijlstra , 1993primary ballon angioplastystreptokinase -
PAMI, 1993primary ballon angioplastyt-PA -
Zwolle, 1994primary ballon angioplastystreptokinaseNegative
Ribichini, 1996primary ballon angioplastyaccelerated t-PA -
Grinfeld, 1996primary ballon angioplastystreptokinase -
Garcia, 1997primary ballon angioplastyaccelerated t-PA -
GUSTO 2B, 1997primary ballon angioplastyaccelerated t-PA -
DANAMI-2, 1997primary ballon angioplastyaccelerated t-PA -
Zijlstra, 1997primary ballon angioplastystreptokinase -
Akhras, 1997primary ballon angioplastystreptokinase -
TRIANA, 2009primary ballon angioplastytenecteplase Risk of bias NegativeNCT00257309
PTCA
TIMI II-A (defered)systematic ballon angioplastyno systematic angioplasty -
TAMI 1 pilot, 1987immediate systematic ballon angioplastyteno immediate angioplasty Exploratory Suggesting
Topol, 1987immediate systematic ballon angioplastyteno immediate angioplasty Exploratory -
Guerci, 1987systematic ballon angioplastyno systematic angioplasty Exploratory Negative
ECSG, 1988immediate systematic ballon angioplastyteno immediate angioplasty Exploratory Negative
TIMI 2A, 1988immediate systematic ballon angioplastyteno immediate angioplasty Exploratory -
Erbel, 1989immediate systematic ballon angioplastyteno immediate angioplasty -
TIMI 2, 1989systematic ballon angioplastyno systematic angioplasty Risk of bias Negative
Barbash, 1990systematic ballon angioplastyno systematic angioplasty -
TAMI-5 (Califf), 1991immediate systematic ballon angioplastyteno immediate angioplasty -
Belenkie, 1991immediate systematic ballon angioplastyteno immediate angioplasty Exploratory -
SWIFT, 1991systematic ballon angioplastyno systematic angioplasty Risk of bias Negative
Van den Brand, 1991systematic ballon angioplastyno systematic angioplasty Exploratory Negative
Belenkie, 1992rescue PTCAno rescue PTCA Risk of bias Negative
SIAM, 1992systematic ballon angioplastyno systematic angioplasty Exploratory Negative
TOPS, 1992systematic ballon angioplastyno systematic angioplasty Exploratory Negative
TAMI 6, 1992systematic ballon angioplastyno systematic angioplasty -
Ellis, 1994immediate systematic ballon angioplastyteno immediate angioplasty -
TOMIIS, 1994late PTCAno PTCANegative
RESCUE, 1994rescue PTCAno rescue PTCANegative
Horie et al, 1998late PTCAno PTCASuggesting
MAASTRICHT (Vermeer), 1999primary angioplastyimmediate thrombolysisNegative
SHOCK (Hochman), 1999immediate systematic ballon angioplastyteno immediate angioplasty Risk of bias SuggestingNCT00000552
SWISS-SMASH, 1999immediate systematic ballon angioplastyteno immediate angioplasty Exploratory Negative
Vermeer, 1999systematic ballon angioplastyno systematic angioplasty -
PRAGUE-1, 2000primary angioplastyimmediate thrombolysisSuggesting
RESCUE II, 2000rescue PTCAno rescue PTCANegative
AIR-PAMI, 2002primary angioplastyimmediate thrombolysisNegative
CAPTIM, 2002primary angioplastyimmediate thrombolysisNegative
TOAT, 2002late PTCAno PTCANegative
DANAMI-2, 2003primary angioplastyimmediate thrombolysisSuggesting
PRAGUE-2, 2003primary angioplastyimmediate thrombolysisSuggesting
MERLIN (Sutton), 2004immediate systematic ballon angioplastyteno immediate angioplasty -
DECOPI, 2004late PTCAno PTCANegative
MERLIN, 2004rescue PTCAno rescue PTCANegative
Silva et al, 2005late PTCAno PTCANegative
REACT (rescue PCI), 2005rescue PTCAno rescue PTCASuggesting
OAT, 2006late PTCAno PTCANegative
TOSCA-2, 2006late PTCAno PTCA - NCT00025766
reteplase
INJECT, 1995reteplasestreptokinaseNegative
RAPID-2, 1996reteplaseaccelerated t-PA Exploratory Suggesting
GUSTO III, 1997reteplaseaccelerated t-PANegative
saruplase
PRIMI (vs SK), 1989saruplasestreptokinase -
PRIMI (vs UK), 1989saruplaseurokinase -
SESAM, 1997saruplaset-PA Exploratory Negative
COMPASS, 1998saruplasestreptokinaseNegative
sirolimus eluting stent
Di Lorenzo et al., 2005sirolimus eluting stentpaclitaxel eluting stentNegative
TYPHOON, 2006sirolimus eluting stentbare-metal stentSuggestingNCT00232830
PROSIT, 2006sirolimus eluting stentpaclitaxel eluting stentNegative
SESAMI, 2007sirolimus eluting stentbare-metal stent Risk of bias SuggestingNCT00288210
Díaz de la Llera, 2007sirolimus eluting stentbare-metal stent -
MISSION, 2008sirolimus eluting stentbare-metal stent Risk of bias SuggestingISRCTN62825862
Juwana, 2009sirolimus eluting stentpaclitaxel eluting stentNegativeISRCTN90526229
streptokinase
ISAM, 1986streptokinaseplaceboNegative
GISSI I, 1986streptokinaseplaceboSuggesting
ISIS 2 pilot, 1987streptokinaseplacebo -
ISIS-2 (SK), 1988streptokinaseplaceboSuggesting
Western Washington Intravenous Trial, 1988streptokinaseplaceboNegative NCT00000507
SAMI (O’Neill), 1992streptokinaseprimary interventionNegative
EMERAS (all delay), 1993streptokinaseplaceboNegative
EMERAS (7-12h), 1993streptokinaseplacebo -
GUSTO tPA-SK Hiv, 1993t-PA + streptokinasestreptokinaseNegative
PRAGUE (Widimisky), 2000streptokinaseprimary interventionNegative
t-pa
ECSG, 1985t-PAstreptokinaseNegative
TIMI-1, 1987t-PAstreptokinase - NCT00000505
ASSET, 1988t-PAplaceboSuggesting
PAIMS, 1989t-PAstreptokinase -
White, 1989t-PAstreptokinase -
GISSI II, 1990t-PAstreptokinaseSuggesting
International Study Group, 1990t-PAstreptokinaseSuggesting
KAMIT, 1991t-PA half doset-PA Exploratory Negative
TAMI 5 (t-PA vs uroK), 1991t-PAurokinase -
TAPS, 1992accelerated t-PAAPSACNegative
TAMI 6, 1992t-PAplaceboNegative
ISIS III (SK/tPA), 1992t-PAstreptokinaseSuggesting
Cherng, 1992t-PAstreptokinaseNegative
RAAMI, 1992accelerated t-PAt-PA -
LATE, 1993t-PAplacebo Low risk of bias Negative
GUSTO tPA Hiv, 1993accelerated t-PAstreptokinaseSuggesting
Centre Illinois, 1993t-PAstreptokinase -
TIMI 4, 1994accelerated t-PAAPSAC -
COBALT, 1997bolus t-PAaccelerated t-PANegative
tenecteplase
ASSENT-2, 1999tenecteplaseaccelerated t-PASuggesting
GRACIA (Fernandez-Aviles,), 2004tenecteplaseprimary interventionNegative
ADVANCE-MI, 2005Eptifibatide + tenecteplaseprimary intervention -
ASSENT-4 PCI (Van de Werf), 2006primary interventionNegative NCT00168792
tirofiban
TIGER-PA (Lee), 2003Tirofibanprimary interventionNegative
Cutlip, 2003Tirofibanprimary interventionNegative
On-Time (van’t Hof), 2004Tirofibanprimary interventionNegative
urokinase
USIM, 1991urokinasecontrol -
zotarolimus eluting stent
ZEST AMI (vs PES), 2009zotarolimus eluting stentpaclitaxel eluting stent Risk of bias NegativeNCT00422565
ZEST AMI (vs SES), 2009zotarolimus eluting stentsirolimus eluting stentNegativeNCT00422565

coronary artery disease

abciximab
Kim, 2010abciximab-coated stentbare-metal stent Exploratory -
angioplasty
AMIST (Reeves), 2004angioplastyMIDCAB Risk of bias -
biolimus eluting stent
LEADERS, 2008biolimus eluting stentsirolimus eluting stentNegativeNCT00389220
Coronary Artery Bypass Surgery
Texas, 1977CABGmedical treatmentNegative
Oregon, 1979CABGmedical treatmentNegative
New zealand 1, 1981CABGmedical treatmentNegative
CASS, 1983CABGmedical treatmentNegativeNCT00000489
VA, 1984CABGmedical treatmentSuggesting
ECSS (European), 1988CABGmedical treatmentSuggesting
Allen, 2000TMR+CABGCABG -
Loubani, 2003TMR+CABGCABG Exploratory -
Zhao, 2006TMR+CABGCABG Exploratory -
MASS II, 2007CABGmedical treatmentNegative
STICH (ventricular reconstruction), 2009CABG+surgical ventricular reconstructionCABGNegativeNCT00023595
BARI 2D, 2009CABG or PCImedical treatment Risk of bias NegativeNCT00006305
dactinomycin eluting stent
ACTION, 2004dactinomycin eluting stentbare-metal stentSuggesting
drug-eluting stents
Hong, 2005PCI withdrug-eluting stentsCABG Risk of bias -
Boudriot, 2008DESCABG Exploratory Negative
FREEDOM, 2012PCI with drug-eluting stentsCABG Risk of bias Negative NCT00086450
ISAR-CABG ongoing drug-eluting stentsbare-metal stent - NCT00611910
Leipzig ongoing drug-eluting stentsCABG - NCT00176397
VA CARDS ongoing PCI withdrug-eluting stentsCABG Risk of bias - NCT00326196
everolimus eluting stent
ISAR-TEST 4 (EES vs SES)everolimus eluting stentsirolimus eluting stentSuggesting
ESSENCE diabeteseverolimus eluting stentsirolimus ES - NCT00997763
FUTURE I, 2004everolimus eluting stentbare-metal stentNegative
SPIRIT I, 2005everolimus eluting stentbare-metal stent Exploratory NegativeNCT00180453
FUTURE II, 2006everolimus eluting stentbare-metal stent -
SPIRIT II, 2006everolimus eluting stentpaclitaxel eluting stent Risk of bias NegativeNCT00180310
SPIRIT III, 2008everolimus eluting stentpaclitaxel eluting stent Exploratory SuggestingNCT00180479
SPIRIT IV, 2010everolimus eluting stentpaclitaxel eluting stent Risk of bias SuggestingNCT00307047
PLATINUM, 2011everolimus eluting stenteverolimus eluting stent - NCT00823212
RESET, 2011everolimus eluting stentsirolimus eluting stent - NCT01035450
SORT OUT IV, 2012everolimus eluting stentsirolimus eluting stent Risk of bias - NCT00552877
LEFT-MAIN-2 ongoing everolimus eluting stentzotarolimus eluting stent - NCT00598637
paclitaxel
PATENCY, 2002paclitaxel, non-polymeric eluting stentbare-metal stentNegative
TAXUS I, 2003paclitaxel eluting stentbare-metal stentNegative
TAXUS II, 2003paclitaxel eluting stentbare-metal stentSuggestingNCT00299026
ASPECT, 2003paclitaxel, non-polymeric eluting stentbare-metal stentSuggestingNCT00196079
TAXUS II (diabetics), 2003paclitaxel eluting stentbare-metal stentSuggesting
TAXUS IV, 2004paclitaxel eluting stentbare-metal stent Low risk of bias SuggestingNCT00292474
ELUTES, 2004paclitaxel, non-polymeric eluting stentbare-metal stentNegative
DELIVER, 2004paclitaxel, non-polymeric eluting stentbare-metal stent Risk of bias Negative
SCORE, 2004paclitaxel eluting stentbare-metal stentSuggesting
ISAR-DESIRE (PES vs PTCA), 2005paclitaxel eluting stentballoon angioplastySuggesting
TAXUS V (all patients), 2005paclitaxel eluting stentbare-metal stentSuggestingNCT00301522
TAXUS VI, 2005paclitaxel eluting stentbare-metal stentSuggestingNCT00297804
TAXUS IV (diabetics), 2005paclitaxel eluting stentbare-metal stentSuggestingNCT00292474
TAXUS V (diabetics), 2005paclitaxel eluting stentbare-metal stentSuggesting
TAXUS VI (diabetics), 2005paclitaxel eluting stentbare-metal stentSuggestingNCT00297804
PASSION, 2006paclitaxel eluting stentbare-metal stent Risk of bias NegativeISRCTN65027270
HAAMU-STENT, 2006paclitaxel eluting stentbare-metal stent Exploratory Negative
ISAR-test (diabetics), 2006paclitaxel eluting stentsirolimus eluting stent Risk of bias -
SYNTAX, 2009paclitaxel eluting stentCABG Risk of bias Suggesting NCT00114972
BASKET-SAVAGE ongoing paclitaxel eluting stentbare-metal stent - NCT00595647
VELETI ongoing paclitaxel eluting stentmedical treatment - NCT00289835
PEPCAD IV ongoing paclitaxel eluting balloonpaclitaxel eluting stent - NCT00462631
FRE-RACE ongoing paclitaxel eluting stentsirolimus eluting stent - NCT00130546
PERSEUS Workhorse, 2010 ongoing paclitaxel eluting stentpaclitaxel eluting stent - NCT00484315
PCI
AVERT, 1995PCI with or without stentmedical treatment Risk of bias Negative
Dakik, 1998PCI with or without stentmedical treatment Risk of bias Negative
AWESOME, 2001PCICABG Risk of bias -
Bech, 2001PCI with or without stentmedical treatment Risk of bias Negative
TIME, 2001PCI with or without stentmedical treatment Risk of bias -
DEFER, 2001FFR-guided PCIno PCINegative
ALKK, 2003PCI with or without stentmedical treatment Risk of bias Suggesting
Hambrecht, 2004PCI with or without stentmedical treatment Risk of bias Negative
COURAGE, 2007PCI with or without stentmedical treatment Risk of bias SuggestingNCT00007657
MASS II, 2007PCI with or without stentmedical treatment Risk of bias Negative
FAME, 2008FFR-guided PCIno PCISuggestingNCT00267774
COMBAT ongoing PCICABG -
Korean Randomized Study ongoing PCICABG -
REVASCULARIZE ongoing PCICABG -
PTCA
ERACI, 1992balloon angioplastyCABGNegative
Toulouse, 1992balloon angioplastyCABGNegative
ACME, 1992balloon angioplastymedical treatment Risk of bias Suggesting
RITA, 1993balloon angioplastyCABGNegative
Sievers, 1993balloon angioplastymedical treatment Risk of bias Negative
EAST, 1994balloon angioplastyCABGNegative NCT00000465
GABI, 1994balloon angioplastyCABGNegative
Lausanne, 1994balloon angioplastyCABGNegative
MASS, 1995balloon angioplastyCABGNegative
CABRI, 1995balloon angioplastyCABGNegative
MASS, 1995balloon angioplastymedical treatment Risk of bias Suggesting
BARI, 1996balloon angioplastyCABGNegativeNCT00000462
RITA 2, 1997balloon angioplastymedical treatment Risk of bias Suggesting
ACME 2 (Folland), 1997balloon angioplastymedical treatment Risk of bias Negative
ACIP, 1997balloon angioplastymedical treatment Exploratory Negative
INSPIRE, 2006balloon angioplastymedical treatment Risk of bias Negative
SWISSI II, 2007balloon angioplastymedical treatment Exploratory Suggesting NCT00387231
sirolimus eluting stent
RAVEL, 2002sirolimus eluting stentbare-metal stentSuggestingNCT00233805
SIRIUS, 2003sirolimus eluting stentbare-metal stent Low risk of bias SuggestingNCT00232765
E-SIRIUS, 2003sirolimus eluting stentbare-metal stentSuggestingNCT00235144
Pasceri, 2003sirolimus eluting stentbare-metal stent -
SIRIUS (diabetics), 2003sirolimus eluting stentbare-metal stent -
C-SIRIUS, 2004sirolimus eluting stentbare-metal stentSuggestingNCT00381420
SES-SMART, 2004sirolimus eluting stentbare-metal stentSuggesting
Ravel (diabetics), 2004sirolimus eluting stentbare-metal stentSuggesting
ISAR-DESIRE (SES vs PTCA), 2005sirolimus eluting stentballoon angioplastySuggesting
DIABETES, 2005sirolimus eluting stentbare-metal stentSuggesting
Pache et al, 2005sirolimus eluting stentbare-metal stentSuggesting
DECODE, 2005sirolimus eluting stentbare-metal stentSuggestingNCT00489164
SES-SMARt (diabetics), 2005sirolimus eluting stentbare-metal stentSuggesting
TAXi, 2005sirolimus eluting stentpaclitaxel eluting stent Risk of bias Negative
ISAR-DESIRE (SES vs PES), 2005sirolimus eluting stentpaclitaxel eluting stentSuggesting
ISAR-DIABETES, 2005sirolimus eluting stentpaclitaxel eluting stentNegative
SIRTAX (Windecker), 2005sirolimus eluting stentpaclitaxel eluting stent Risk of bias Suggesting
CORPAL, 2005sirolimus eluting stentpaclitaxel eluting stentNegative
BASKET (vs paclitaxel), 2005sirolimus eluting stentpaclitaxel eluting stentNegative
Di Lorenzo et al., 2005sirolimus eluting stentpaclitaxel eluting stentNegative
SIRTAX diabetics, 2005sirolimus eluting stentpaclitaxel eluting stentNegativeNCT00297661
PRISON II, 2006sirolimus eluting stentbare-metal stent Risk of bias SuggestingNCT00258596
SCANDSTENT, 2006sirolimus eluting stentbare-metal stentSuggestingNCT00151658
TYPHOON, 2006sirolimus eluting stentbare-metal stentSuggestingNCT00232830
REALITY, 2006sirolimus eluting stentpaclitaxel eluting stent Risk of bias SuggestingNCT00235092
ISAR-SMART 3, 2006sirolimus eluting stentpaclitaxel eluting stentNegativeNCT00146575
Zhang (SES vs PES), 2006sirolimus eluting stentpaclitaxel eluting stent Exploratory Negative
LONG DES II, 2006sirolimus eluting stentpaclitaxel eluting stent Risk of bias Suggesting
PROSIT, 2006sirolimus eluting stentpaclitaxel eluting stentNegative
Cervinka, 2006sirolimus eluting stentpaclitaxel eluting stentNegative
Han, 2006sirolimus eluting stentpaclitaxel eluting stentNegative
ISAR-TEST-1, 2006sirolimus eluting stentpaclitaxel eluting stent Risk of bias NegativeNCT00140530
REALITY (diabetics), 2006sirolimus eluting stentpaclitaxel eluting stentNegative
Kochiadakis, 2007sirolimus eluting stentbare-metal stent Exploratory -
SESAMI, 2007sirolimus eluting stentbare-metal stent Risk of bias SuggestingNCT00288210
SCORPIUS, 2007sirolimus eluting stentbare-metal stentSuggestingNCT00495898
Ortolani et al, 2007sirolimus eluting stentbare-metal stent -
Petronio et al, 2007sirolimus eluting stentpaclitaxel eluting stentNegative
Pan, 2007sirolimus eluting stentpaclitaxel eluting stent Exploratory Suggesting
MISSION, 2008sirolimus eluting stentbare-metal stent Risk of bias SuggestingISRCTN62825862
Tomai, 2008sirolimus eluting stentpaclitaxel eluting stent -
SORT OUT II, 2008sirolimus eluting stentpaclitaxel eluting stentNegativeNCT00388934
DES-DIABETES, 2008sirolimus eluting stentpaclitaxel eluting stent Risk of bias Suggesting
Thiele, 2009PCI withsirolimus ESMIDCAB Risk of bias - NCT00299429
ISAR-LEFT-MAIN, 2009sirolimus eluting stentpaclitaxel eluting stentNegativeNCT00133237
GISSOC II, 2010sirolimus eluting stentbare-metal stent Exploratory Suggesting NCT00220558
PRECOMBAT, 2011sirolimus eluting stentCABG - NCT00422968
TAxi (diabetics)sirolimus eluting stentpaclitaxel eluting stent -
Gao ongoing sirolimus eluting stentFirebird eluting stent - NCT00887211
MIDCAB Versus DES in Proximal LAD Lesions ongoing sirolimus eluting stentCABG - NCT00299429
Munich Study ongoing sirolimus eluting stentCABG -
FOCUS ongoing sirolimus eluting stentcutting ballon angioplasty - NCT00485004
DES-ISR ongoing sirolimus eluting stentpaclitaxel eluting stent - NCT00485030
Lipsia-Yukon-DM ongoing sirolimus eluting stentpaclitaxel eluting stent - NCT00368953
BASKET-PROVE, 2008 ongoing sirolimus eluting stentbare-metal stent -
zotarolimus eluting stent
ENDEAVOR II, 2006zotarolimus eluting stentbare-metal stentSuggesting
ENDEAVOR III, 2006zotarolimus eluting stentsirolimus eluting stentSuggesting NCT00217256
ZoMaxx I, 2008zotarolimus eluting stentpaclitaxel eluting stent -
ENDEAVOR IV, 2009zotarolimus eluting stentpaclitaxel eluting stent Risk of bias SuggestingNCT00217269
ZEST AMI (vs PES), 2009zotarolimus eluting stentpaclitaxel eluting stent Risk of bias NegativeNCT00422565
ZEST (vs PES), 2009zotarolimus eluting stentpaclitaxel eluting stentSuggestingNCT00418067
ZEST (vs SES), 2009zotarolimus eluting stentsirolimus eluting stent Risk of bias NegativeNCT00418067
ZEST AMI (vs SES), 2009zotarolimus eluting stentsirolimus eluting stentNegativeNCT00422565
RESOLUTE All comers, 2010zotarolimus eluting stenteverolimus eluting stent Risk of bias NegativeNCT00617084.)
TWENTE, 2012zotarolimus eluting stenteverolimus eluting stent - NCT01066650
PROTECT, 2012zotarolimus eluting stentsirolimus eluting stent Risk of bias - NCT00476957
ZoMaxx phase 2 ongoing zotarolimus eluting stentpaclitaxel eluting stent - NCT00140101
DIABEDES IV ongoing zotarolimus eluting stentsirolimus eluting stent - NCT00552994
PRISON III, 2007 ongoing zotarolimus eluting stentsirolimus eluting stent - NCT00428454

stable angina

angioplasty
AMIST (Reeves), 2004angioplastyMIDCAB Risk of bias -
biolimus eluting stent
LEADERS, 2008biolimus eluting stentsirolimus eluting stentNegativeNCT00389220
Coronary Artery Bypass Surgery
Texas, 1977CABGmedical treatmentNegative
Oregon, 1979CABGmedical treatmentNegative
New zealand 1, 1981CABGmedical treatmentNegative
CASS, 1983CABGmedical treatmentNegativeNCT00000489
VA, 1984CABGmedical treatmentSuggesting
ECSS (European), 1988CABGmedical treatmentSuggesting
Allen, 2000TMR+CABGCABG -
Loubani, 2003TMR+CABGCABG Exploratory -
Zhao, 2006TMR+CABGCABG Exploratory -
MASS II, 2007CABGmedical treatmentNegative
STICH (ventricular reconstruction), 2009CABG+surgical ventricular reconstructionCABGNegativeNCT00023595
BARI 2D, 2009CABG or PCImedical treatment Risk of bias NegativeNCT00006305
dactinomycin eluting stent
ACTION, 2004dactinomycin eluting stentbare-metal stentSuggesting
drug-eluting stents
Hong, 2005PCI withdrug-eluting stentsCABG Risk of bias -
Boudriot, 2008DESCABG Exploratory Negative
FREEDOM, 2012PCI with drug-eluting stentsCABG Risk of bias Negative NCT00086450
ISAR-CABG ongoing drug-eluting stentsbare-metal stent - NCT00611910
Leipzig ongoing drug-eluting stentsCABG - NCT00176397
VA CARDS ongoing PCI withdrug-eluting stentsCABG Risk of bias - NCT00326196
everolimus eluting stent
ISAR-TEST 4 (EES vs SES)everolimus eluting stentsirolimus eluting stentSuggesting
FUTURE I, 2004everolimus eluting stentbare-metal stentNegative
SPIRIT I, 2005everolimus eluting stentbare-metal stent Exploratory NegativeNCT00180453
FUTURE II, 2006everolimus eluting stentbare-metal stent -
SPIRIT II, 2006everolimus eluting stentpaclitaxel eluting stent Risk of bias NegativeNCT00180310
SPIRIT III, 2008everolimus eluting stentpaclitaxel eluting stent Exploratory SuggestingNCT00180479
COMPARE, 2009everolimus eluting stentpaclitaxel eluting stent Risk of bias SuggestingNCT01016041
SPIRIT IV, 2010everolimus eluting stentpaclitaxel eluting stent Risk of bias SuggestingNCT00307047
SORT OUT IV, 2012everolimus eluting stentsirolimus eluting stent Risk of bias - NCT00552877
LEFT-MAIN-2 ongoing everolimus eluting stentzotarolimus eluting stent - NCT00598637
paclitaxel
PATENCY, 2002paclitaxel, non-polymeric eluting stentbare-metal stentNegative
TAXUS I, 2003paclitaxel eluting stentbare-metal stentNegative
TAXUS II, 2003paclitaxel eluting stentbare-metal stentSuggestingNCT00299026
ASPECT, 2003paclitaxel, non-polymeric eluting stentbare-metal stentSuggestingNCT00196079
TAXUS IV, 2004paclitaxel eluting stentbare-metal stent Low risk of bias SuggestingNCT00292474
ELUTES, 2004paclitaxel, non-polymeric eluting stentbare-metal stentNegative