new version V2017

prevention

     

TrialStudied treatmentControl treatmentpatientsROBResultNCT

atrial fibrillation

atorvastatin
MIRACL (AF ancillary study), 2001atorvastatinplacebo Exploratory Negative
MIRACL (sub-group) (Schwartz), 2004atorvastatinplacebo Exploratory Suggesting
Ozaydin, 2006atorvastatincontrol Exploratory Suggesting
Dernellis, 2006atorvastatinplacebo Exploratory Suggesting
ARMYDA-3 (AF ancillary study), 2006atorvastatinplaceboSuggesting
Chello, 2006atorvastatinplacebo Exploratory Negative
Almroth, 2009atorvastatin placebo Risk of bias Suggesting
STOP-AF ongoing atorvastatinplacebo - NCT00252967
candesartan
CHARM (AF ancillary study), 2005candesartanplaceboSuggesting
CAPRAF (Tveit), 2007candesartanplacebo Risk of bias - NCT00130975
enalapril
Ueng, 2003enalaprilcontrolSuggesting
SOLVD (AF ancillary study), 2003enalaprilplaceboSuggesting
gemfibrozil
VA HIT (AF ancillary study), 1999gemfibrozilplacebo Exploratory Negative
irbesartan
Madrid, 2002irbesartancontrolSuggesting
ACTIVE I, 2009irbesartanplacebo Low risk of bias SuggestingNCT00249795
lisinopril
Van den Burg, 1995lisinoprilplaceboNegative
GISSI-3 (AF ancillary study), 2003lisinoprilplaceboNegative
losartan
LIFE (AF ancillary study), 2005losartanatenololSuggesting
olmesartan
ANTIPAF ongoing olmesartanplacebo Low risk of bias - NCT00098137
pravastatin
Tveit, 2004pravastatincontrol Exploratory Negative
ramipril
Brown ongoing ramiprilplacebo - NCT00141778
rosuvastatin
GISSI HF (subgroup and ancillary study), 2009rosuvastatin placebo Exploratory NegativeNCT00336336
valsartan
Val-HeFT (AF ancillary study), 2003valsartanplaceboSuggesting
GISSI-AF (Disertori), 2009valsartanplacebo Low risk of bias NegativeNCT00376272

diabetes type 2

diet
Liao, 2002AHA 2 dietAHA 1 diet Exploratory Negative
glargine
GRACE - ORIGIN (glargine), 2012insulin glargineplacebo -
glipizide
Eriksson, 2006glipizideplacebo Exploratory Negative
metformin
Jarret, 1979lifestyle modification + metformincontrol Exploratory Negative
Sirtori, 1984metforminplacebo -
Giugliano, 1993metforminplacebo -
Crave, 1995metforminplacebo -
Charles, 1998metforminplaceboNegative
Li, 1999metforminplacebo Exploratory Negative
Morel, 1999metforminplacebo -
Charles, 2000metforminplacebo -
Moghetti, 2000metforminplacebo -
Pasquali, 2000metforminplacebo -
Freemark, 2001metforminplacebo -
Kay, 2001metforminplacebo -
Lehtovirta, 2001metforminplaceboNegative
Ng, 2001metforminplacebo -
US-DPP (metformin) (Knowler), 2002metforminplacebo Low risk of bias Negative
Fleming, 2002metforminplacebo -
Kelly, 2002metforminplacebo -
Kocak, 2002metforminplacebo -
Sturrock, 2002metforminplacebo -
EDIT (Holman), 2003metforminplacebo -
Choux, 2003metforminplacebo -
Baillargeon, 2004metforminplacebo -
Gambineri, 2004metforminplacebo -
Hoeger, 2004metforminplacebo -
Rodriguez, 2004metforminplacebo -
Rodriguez-Moctezuma, 2004metforminplaceboNegative
James, 2005metformincontrol -
Orchard, 2005metforminplaceboSuggesting
Stakos, 2005metforminplacebo -
Vitale, 2005metforminplacebo -
IDDP (Ramachandran), 2006lifestyle modification + metformincontrol Risk of bias Negative
Bridger, 2006metforminplacebo -
Srinivasan, 2006metforminplacebo -
Tang, 2006metforminplacebo -
CANOE, 2010rosiglitazone and metforminplacebo Low risk of bias SuggestingNCT00116932
nateglinide
NAVIGATOR nateglinide, 2010nateglinideplacebo Low risk of bias Negative NCT00097786
orlistat
Heymsfield, 2000orlistatplacebo Low risk of bias Negative
XENDOS (Chiasson), 2002orlistatplacebo Risk of bias Negative
ramipril
DREAM ramipril, 2006ramiprilplacebo Low risk of bias Negative NCT00095654
rosiglitazone
DREAM rosiglitazone, 2006rosiglitazoneplacebo Low risk of bias Suggesting NCT00095654
troglitazone
TRIPOD (Buchanan), 2002troglitazoneplacebo Exploratory -
US DDP troglitazone (Knowler), 2005troglitazoneplacebo Low risk of bias -
valsartan
NAVIGATOR valsartan, 2010valsartanplacebo Low risk of bias SuggestingNCT00097786
voglibose
Voglibose Ph-3, 2009vogliboseplacebo Low risk of bias SuggestingUMIN 000001109-

impaired fasting glucose

glargine
GRACE - ORIGIN (glargine), 2012insulin glargineplacebo -
metformin
US-DPP (metformin) (Knowler), 2002metforminplacebo Low risk of bias Negative
CANOE, 2010rosiglitazone and metforminplacebo Low risk of bias SuggestingNCT00116932
nateglinide
NAVIGATOR nateglinide, 2010nateglinideplacebo Low risk of bias Negative NCT00097786
ramipril
DREAM ramipril, 2006ramiprilplacebo Low risk of bias Negative NCT00095654
rosiglitazone
DREAM rosiglitazone, 2006rosiglitazoneplacebo Low risk of bias Suggesting NCT00095654
valsartan
NAVIGATOR valsartan, 2010valsartanplacebo Low risk of bias SuggestingNCT00097786
voglibose
Voglibose Ph-3, 2009vogliboseplacebo Low risk of bias SuggestingUMIN 000001109-

post stroke

folic acid
VISP (Toole), 2004high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6 Low risk of bias Negative
VITATOPS, 2010folic acid, vit B12 and vit B6placebo Low risk of bias SuggestingNCT00097669ÐX&