new version V2017

fibrinolysis

Alteplase - Anistreplase - APSAC - Lanoteplase - Reteplase - Rt-PA - Saruplase - Streptokinase - T-pa - Tenecteplase - Urokinase      

TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

anistreplase
UNASEM, 1992anistreplaseplacebo Exploratory -
t-pa
Gold, 1987t-PAplacebo Exploratory -
Topol, 1988t-PAplacebo Exploratory Negative
Nicklas, 1989t-PAplacebo Exploratory Negative
Williams, 1990t-PAplacebo Exploratory Negative
Ardissino, 1990t-PAplacebo Exploratory Negative
van der Brand, 1991t-PAplacebo Exploratory Negative
Freeman, 1992t-PAplacebo Low risk of bias Negative
charbonnier, 1992t-PAplacebo Exploratory -
TIMI 3A, 1993t-PAplacebo Exploratory -
TIMI 3B, 1995t-PAplacebo Low risk of bias -

acute myocardial infarction

anistreplase
TEAM 2, 1991anistreplasestreptokinase -
APSAC
AIMS, 1988APSACplaceboSuggesting
German Multicenter Trial, 1988APSACplaceboSuggesting
APSIM, 1989APSACcontrolNegative
ISIS III (SK/APSAC), 1992APSACstreptokinaseNegative
TEAM 3, 1992APSACt-PA -
lanoteplase
InTIME-II, 2000lanoteplaseaccelerated t-PANegative
reteplase
INJECT, 1995reteplasestreptokinaseNegative
RAPID-2, 1996reteplaseaccelerated t-PA Exploratory Suggesting
GUSTO III, 1997reteplaseaccelerated t-PANegative
saruplase
PRIMI (vs SK), 1989saruplasestreptokinase -
PRIMI (vs UK), 1989saruplaseurokinase -
SESAM, 1997saruplaset-PA Exploratory Negative
COMPASS, 1998saruplasestreptokinaseNegative
streptokinase
ISAM, 1986streptokinaseplaceboNegative
GISSI I, 1986streptokinaseplaceboSuggesting
ISIS 2 pilot, 1987streptokinaseplacebo -
ISIS-2 (SK), 1988streptokinaseplaceboSuggesting
Western Washington Intravenous Trial, 1988streptokinaseplaceboNegative NCT00000507
EMERAS (all delay), 1993streptokinaseplaceboNegative
EMERAS (7-12h), 1993streptokinaseplacebo -
GUSTO tPA-SK Hiv, 1993t-PA + streptokinasestreptokinaseNegative
t-pa
ECSG, 1985t-PAstreptokinaseNegative
TIMI-1, 1987t-PAstreptokinase - NCT00000505
ASSET, 1988t-PAplaceboSuggesting
PAIMS, 1989t-PAstreptokinase -
White, 1989t-PAstreptokinase -
GISSI II, 1990t-PAstreptokinaseSuggesting
International Study Group, 1990t-PAstreptokinaseSuggesting
KAMIT, 1991t-PA half doset-PA Exploratory Negative
TAMI 5 (t-PA vs uroK), 1991t-PAurokinase -
TAPS, 1992accelerated t-PAAPSACNegative
TAMI 6, 1992t-PAplaceboNegative
ISIS III (SK/tPA), 1992t-PAstreptokinaseSuggesting
Cherng, 1992t-PAstreptokinaseNegative
RAAMI, 1992accelerated t-PAt-PA -
LATE, 1993t-PAplacebo Low risk of bias Negative
GUSTO tPA Hiv, 1993accelerated t-PAstreptokinaseSuggesting
Centre Illinois, 1993t-PAstreptokinase -
TIMI 4, 1994accelerated t-PAAPSAC -
COBALT, 1997bolus t-PAaccelerated t-PANegative
tenecteplase
ASSENT-2, 1999tenecteplaseaccelerated t-PASuggesting
urokinase
USIM, 1991urokinasecontrol -

cardiac arrest

t-pa
Abu-Laban, 2002t-PAplacebo Exploratory Negative
tenecteplase
TICA, 2004tenecteplaseplacebo Exploratory Negative
TROICA, 2008tenecteplaseplacebo Low risk of bias NegativeNCT00157261

pulmonary embolism

candesartan
Tebbe, 2009desmoteplasealteplase Exploratory -
rt-PA
PIOPED, 1990rt-PAplacebo Exploratory Negative
Levine, 1990rt-PAplacebo Low risk of bias Negative
PAIMS 2, 1992rt-PAno fibrinolysis Exploratory Negative
Goldhaber, 1993rt-PAno fibrinolysis Exploratory Negative
Konstantinides, 2002rt-PAplacebo Low risk of bias Negative
streptokinase
Tibbutt, 1974streptokinaseno fibrinolysis Exploratory Negative
Ly, 1978streptokinaseno fibrinolysis Exploratory Negative
Jerjes-Sanchez, 1995streptokinaseno fibrinolysis Exploratory -
tenecteplase
PEITHO ongoing tenecteplaseplacebo - NCT00639743
urokinase
UPET, 1973urokinaseplacebo Low risk of bias Negative
Marini, 1988urokinaseno fibrinolysis Exploratory -

venous thrombosis

heparin
Schweizer tPA, 1998tPA+heparinno fibrinolysisNegative
streptokinase
Kakkar (streptokinase), 1969streptokinaseno fibrinolysisNegative
Tsapogas, 1973streptokinaseno fibrinolysisNegative
Common, 1976streptokinaseno fibrinolysisNegative
Arneson, 1978streptokinaseno fibrinolysisNegative
Schulman, 1986streptokinaseno fibrinolysisNegative
Schweizer (systemic SK), 2000streptokinaseno fibrinolysis -
Elsharawy, 2002streptokinaseno fibrinolysisNegative
t-pa
Verhaeghe (high dose), 1989tPAno fibrinolysis -
Verhaeghe (low dose), 1989tPAno fibrinolysis -
Goldhaber (tPA alone), 1990tPAno fibrinolysisNegative
Turpie, 1990tPAno fibrinolysisNegative
Goldhaber (tPA+heparin), 1990tPAno fibrinolysis -
Schweizer (local tPA), 2000tPAno fibrinolysis -
urokinase
Kiil, 1981urokinaseno fibrinolysisNegative
Schweizer (urokinase), 1998urokinaseno fibrinolysisNegative
Schweizer (local urokinase), 2000urokinaseno fibrinolysis -
Schweizer (systemic urokinase), 2000urokinaseno fibrinolysis -