direct antithrombins

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treatment    comparator  All cause death All cause death Coronary event Coronary event Adverse events Bleeding Cardiovascular death Major bleeding Major bleeding Minor bleeding Haemmorhagic stroke Fatal stroke Non fatal stroke Fatal bleeding thrombo-embolic event (cerebral or systemic) ischemic stroke  hypertransaminasemia intracranial hemorrhage TE event or ischemic stroke or systemic embolism stroke (fatal and non fatal)  myocardial infarction (fatal and non fatal)  myocardial infarction (fatal and non fatal)  Deep vein thrombosis  proximal DVT  distal DVT  non-fatal pulmonary embolism  asymptomatic DVT  total VTE and all-cause mortality  Venous thromboembolism Symptomatic venous thromboembolism (DVT, PE) major VTE (fatal and non fatal DVT,PE)  Gastrointestinal major bleeding  Non-lifethreatening major bleeding  Lifethreatening major bleeding Acute coronary syndrome Symptomatic deep-vein thrombosis major or clinically relevant non-major bleeding any bleedings systemic thrombo-embolic complication      
Dabigatranatrial fibrillation, in all type of patients vs warfarin standard dose by 10% by 10% NSNS- by 16% by 12% by 13% by 13% by 15% by 71% by 19% by 25% NS by 22% NS- by 64% NS by 22% by 36% by 36% --------- by 30% NS by 25% ----NS
Dabigatranthrombosis prevention, in all type of patients vs enoxaparinNSNSNSNS---NSNS--------------NSNSNSNSNS--NS---- by 635% ---
Dabigatranthrombosis prevention, in all type of patients vs enoxaparin (europe regimen)NSNSNSNS---NSNS--------------NSNSNSNSNS--NS---- by 73% NS--
Dabigatranthrombosis prevention, in all type of patients vs enoxaparin (US regimen)NSNSNSNS--- by 58% by 58% --------------NS by 26% NS- by 28% --NS-----NS--
Ximelagatranatrial fibrillation, in all type of patients vs warfarin standard doseNSNSNSNSNS by 16% NS by 27% by 27% NSNSNS--NSNS by 681% -NSNSNSNS----------------NS
Ximelagatranthrombosis prevention, in orthopedic surgery vs Dalteparin-------NSNS------------------- by 45% ----------
Ximelagatranthrombosis prevention, in orthopedic surgery vs Enoxaparin-------NSNS-------------------NS----------