IRIS, 2016 trial summary    PDF trial summary

A randomised clinical trial investigating the effect of pioglitazone versus placebo in


NCT00091949    N Engl J Med 2016 Apr 7;374:1321-31  

Studied treatment
Control treatment

Group sizes-9 / -9
primary prevention
history of cardiovascular

Blindness Inclusion period
Follow-up duration Centers
Lost to FU geographical localisation
Primary endpoint Design

EndpointX1N1X0N0TE95% CI0,22,01,0

Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP Jr, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Sp Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. N Engl J Med 2016 Apr 7;374:1321-31     [PMID: 26886418]   link to pdf   add to Mendeley record NCT00091949

Registering number NCT00091949 (see trial on
Code Name