MAGIC, 2001 trial summary    PDF trial summary

A randomised clinical trial investigating the effect of myoblasts versus placebo in patient with severe ischaemic heart failure

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Lancet 2001;357:279-80  



Studied treatment autologous skeletal myoblasts into the postinfarction scar during coronary artery bypass grafting of remote myocardial areas
Control treatment placebo
cell type Skeletal myoblasts
Cell injection procedure Epimyocardial



Patients patient with severe ischaemic heart failure
Group sizes63 / 34



Blindness Inclusion period
Follow-up duration 6 mo Centers
Lost to FU geographical localisation
Primary endpoint Design



EndpointX1N1X0N0TE95% CI 6-min Walk, m - 53 - 30 no data all-cause mortality 9 63 2 34 Out of scale2,43[0,49; 11,95] LVEF - 53 - 30 no data acute heart failure - -9 - -9 no data LV End-Systolic Volume - -9 - -9 no data ventricular tachycardia 9 63 2 34 Out of scale2,43[0,49; 11,95] NT-proBNP - -9 - -9 no data NYHA deterioration - -9 - -9 no data Peak VO2 (mL/kg/min) - -9 - -9 no data NYHA class - -9 - -9 no data cardiac event - 63 - 34 no data Minnesota Living With Heart Failure Questionnaire - -9 - -9 no data0,22,01,0

MenaschĂ© P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, Schwartz K, Vilquin JT, Marolleau JP Myoblast transplantation for heart failure. Lancet 2001;357:279-80     [PMID: 11214133]   link to pdf   add to Mendeley  



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