C CURE, 2013 trial summary

A randomised clinical trial investigating the effect of Cardiopoietic stem cell versus control in patients with heart failure of ischemic origin

NCT00810238    J Am Coll Cardiol 2013;62:2453  




Studied treatment autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy
bone marrow was harvested and isolated mesenchymal stem cells were exposed to a cardiogenic cocktail. Derived cardiopoietic stem cells, meeting release criteria under Good Manufacturing Practice, were delivered by endomyocardial injections guided by left ventricular electromechanical mapping
Control treatment



Patients patients with heart failure of ischemic origin
Group sizes -9 / -9



Blindness Inclusion period
Follow-up duration Centers
Lost to FU geographical localisation
Primary endpoint Design



EndpointX1N1X0N0TE95% CI cardiac event - -9 - -9 no data0,22,01,0


Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschel Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol 2013;61:2329-38     [PMID: 23583246]   link to pdf  

Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschelde JL, Crespo-Diaz R, Homsy C, Tendera M, Waldman S, Wijns W, Terzic A Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol 2013;61:2329-38     [PMID: 23583246]   link to pdf  

Mielewczik M, Cole GD, Nowbar AN, Schilling R, Whinnett ZI, Bordachar P, Wilmshurst P, Chambers JC, Olshansky B, Morgan J, Israel C, Sethi AS, van Houwelingen M, Cleland JG, Schmidt G, Francis DP The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE). J Am Coll Cardiol 2013;62:2453     [PMID: 24355589]   link to pdf  



Registering number NCT00810238 (see trial on clinicaltrials.gov)
Code Name NCT00810238

 




Appears in following systematic reviews: