TOPCARE-CHD, 2006 trial summary

A randomised clinical trial investigating the effect of Bone marrow mononuclear cells versus control in patients with stable ischemic heart disease who had had a myocardial infarction at least 3 months previously

NCT00289822    N Engl J Med 2006;355:1222-32  




Studied treatment intracoronary transplantation of progenitor cells derived from bone marrow (BMC) or circulating blood
Control treatment



Patients patients with stable ischemic heart disease who had had a myocardial infarction at least 3 months previously
Group sizes -9 / -9



Blindness Inclusion period
Follow-up duration Centers
Lost to FU geographical localisation
Primary endpoint Design



EndpointX1N1X0N0TE95% CI LVEF - -9 - -9 no data acute heart failure - -9 - -9 no data LV End-Systolic Volume - -9 - -9 no data ventricular tachycardia - -9 - -9 no data NT-proBNP - -9 - -9 no data NYHA deterioration - -9 - -9 no data Peak VO2 (mL/kg/min) - -9 - -9 no data NYHA class - -9 - -9 no data cardiac event - -9 - -9 no data Minnesota Living With Heart Failure Questionnaire - -9 - -9 no data 6-min Walk, m - -9 - -9 no data all-cause mortality - -9 - -9 no data0,22,01,0


Assmus B, Honold J, Sch├Ąchinger V, Britten MB, Fischer-Rasokat U, Lehmann R, Teupe C, Pistorius K, Martin H, Abolmaali ND, Tonn T, Dimmeler S, Zeiher AM Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006;355:1222-32     [PMID: 16990385]   link to pdf  



Registering number NCT00289822 (see trial on clinicaltrials.gov)
Code Name

 




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