Ang, 2008 trial summary

A randomised clinical trial investigating the effect of Bone marrow mononuclear cells versus control in Elective CABG patients with established myocardial scars diagnosed as akinetic or dyskinetic segments by dobutamine stress echocardiography and confirmed at surgery

Nat Clin Pract Cardiovasc Med 2008;5:663-70  




Studied treatment transplantation of autologous bone marrow cells
intramuscular or intracoronary administration of BMCs into nonviable scarred myocardium during CABG
Control treatment



Patients Elective CABG patients with established myocardial scars diagnosed as akinetic or dyskinetic segments by dobutamine stress echocardiography and confirmed at surgery
Group sizes -9 / -9



Blindness single-blinded Inclusion period
Follow-up duration Centers
Lost to FU geographical localisation
Primary endpoint Design



EndpointX1N1X0N0TE95% CI LV End-Systolic Volume - -9 - -9 no data ventricular tachycardia - -9 - -9 no data NT-proBNP - -9 - -9 no data NYHA deterioration - -9 - -9 no data Peak VO2 (mL/kg/min) - -9 - -9 no data NYHA class - -9 - -9 no data cardiac event - -9 - -9 no data Minnesota Living With Heart Failure Questionnaire - -9 - -9 no data 6-min Walk, m - -9 - -9 no data all-cause mortality - -9 - -9 no data LVEF - -9 - -9 no data acute heart failure - -9 - -9 no data0,22,01,0


Ang KL, Chin D, Leyva F, Foley P, Kubal C, Chalil S, Srinivasan L, Bernhardt L, Stevens S, Shenje LT, GaliƱanes M Randomized, controlled trial of intramuscular or intracoronary injection of autologous bone marrow cells into scarred myocardium during CABG versus CABG alone. Nat Clin Pract Cardiovasc Med 2008;5:663-70     [PMID: 18711405]   link to pdf  



Registering number (see trial on clinicaltrials.gov)
Code Name

 




Appears in following systematic reviews: