CADUCEUS, 2012 trial summary    PDF trial summary

A randomised clinical trial investigating the effect of Cardiopoietic stem cell versus control in patients with left ventricular dysfunction after myocardial infarction

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NCT00893360    Lancet 2012;379:895-904  



Studied treatment
Control treatment



Patients patients with left ventricular dysfunction after myocardial infarction
Group sizes17 / -9
Inclusion criteriapatients 2-4 weeks after myocardial infarction (with left ventricular ejection fraction of 25-45%)



Blindness Inclusion period May 5, 2009, and Dec 16, 2010
Follow-up duration Centers
Lost to FU geographical localisation
Primary endpoint Design
PeriodeInclusionMay 5, 2009, and Dec 16, 2010



EndpointX1N1X0N0TE95% CI 6-min Walk, m - -9 - -9 no data all-cause mortality - -9 - -9 no data LVEF - -9 - -9 no data acute heart failure - -9 - -9 no data LV End-Systolic Volume - -9 - -9 no data ventricular tachycardia - -9 - -9 no data NT-proBNP - -9 - -9 no data NYHA deterioration - -9 - -9 no data Peak VO2 (mL/kg/min) - -9 - -9 no data NYHA class - -9 - -9 no data cardiac event - 17 - -9 no data Minnesota Living With Heart Failure Questionnaire - -9 - -9 no data0,22,01,0

Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 2012;379:895-904     [PMID: 22336189]   link to pdf   add to Mendeley  

ClinicalTrial.gov record NCT00893360



Registering number NCT00893360 (see trial on clinicaltrials.gov)
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