coronary artery disease - Drug eluting stent - all type of patients clinical trials results meta-analysis

<h1> <a href="index.html"> <strong>coronary artery disease</strong> - Drug eluting stent </a> - all type of patients trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="index.html"> Tomai, 2008 </a> <br> </td> <td> sirolimus-eluting stent<br>  <i>versus</i> <br> paclitaxel-eluting stent </td> <td> diabetic patient with multiple de novo coronary artery lesions </td> <td> follow-up 8 months<br> n=60/60<br> Cross over<br> NA <br> Italy </td> </tr> <tr> <td> <a href="index.html"> Kochiadakis, 2007 </a> <br> </td> <td> sirolimus-eluting stents<br>  <i>versus</i> <br> bare metal stent </td> <td> one-vesseldisease (>70% narrowing of the lumen of one major epicardialcoronary artery); stable coronary artery disease, age <70 years, and vessel referencediameter >=2.5 mm </td> <td> follow-up 4.8 months (mean)<br> n=38/43<br> Parallel groups<br> open <br> Greece </td> </tr> <tr> <td> <a href="index.html"> RAVEL, 2002 </a> <br> NCT00233805 </td> <td> coated Bx Velocity<br>  <i>versus</i> <br> Bx Velocity </td> <td> Stable or unstable AP, silent ischaemia; single primary target lesion in a native coronary artery </td> <td> follow-up 12 months<br> n=120/118<br> Parallel groups<br> double-blind <br> Global </td> </tr> <tr> <td> <a href="index.html"> SIRIUS, 2003 </a> <br> NCT00232765 </td> <td> SES<br>  <i>versus</i> <br> Bx Velocity </td> <td> Stable or unstable AP, signs of myocardial ischaemia </td> <td> follow-up 9 months<br> n=533/525<br> Parallel groups<br> double-blind <br> United States </td> </tr> <tr> <td> <a href="index.html"> C-SIRIUS, 2004 </a> <br> NCT00381420 </td> <td> coated Bx-VELOCITY<br>  <i>versus</i> <br> Bx-VELOCITY </td> <td> Stable or unstable AP, silent ischaemia </td> <td> follow-up 9 months<br> n=50/50<br> Parallel groups<br> double-blind <br> Canada </td> </tr> <tr> <td> <a href="index.html"> E-SIRIUS, 2003 </a> <br> NCT00235144 </td> <td> coated Bx Velocity<br>  <i>versus</i> <br> Bx Velocity </td> <td> Stable or unstable AP, silent ischaemia; single-vessel or multivessel coronary disease but with only one new lesion with an estimated stenosis of more than 50% but less than 100% in a major native coronary artery requiring treatment </td> <td> follow-up 9 months<br> n=175/177<br> Parallel groups<br> open <br> Europe </td> </tr> <tr> <td> <a href="index.html"> TAXUS I, 2003 </a> <br> </td> <td> TAXUS NIR<br>  <i>versus</i> <br> NIR stent </td> <td> Stable or unstable AP, silent ischaemia; single de novo or restenotic coronary lesions </td> <td> follow-up 12 months<br> n=31/30<br> Parallel groups<br> double-blind <br> Germany </td> </tr> <tr> <td> <a href="index.html"> TAXUS II, 2003 </a> <br> NCT00299026 </td> <td> TAXUS<br>  <i>versus</i> <br> NIR stent </td> <td> Stable or unstable AP, silent ischaemia; single de novo target lesion with estimatedstenosis >50% and <99%, </td> <td> follow-up 12 months<br> n=266/270<br> Parallel groups<br> double-blind <br> Global </td> </tr> <tr> <td> <a href="index.html"> TAXUS IV, 2004 </a> <br> NCT00292474 </td> <td> TAXUS<br>  <i>versus</i> <br> EXPRESS </td> <td> Stable or unstable AP, provokable ischaemia with a single, previously untreated coronary-artery stenosis (vessel diameter, 2.5 to 3.75 mm; lesion length, 10 to 28 mm) </td> <td> follow-up 9 months<br> n=662/652<br> Parallel groups<br> double-blind <br> United States </td> </tr> <tr> <td> <a href="index.html"> ASPECT, 2003 </a> <br> NCT00196079 </td> <td> coated Supra-G stent<br>  <i>versus</i> <br> Supra-G stent </td> <td> patientswith discrete coronary lesions (<15 mm in length, 2.25 to 3.5 mm in diameter) </td> <td> follow-up 6 months<br> n=117/58<br> Parallel groups<br> double-blind <br> NA </td> </tr> <tr> <td> <a href="index.html"> ELUTES, 2004 </a> <br> </td> <td> coated V-Flex Plus<br>  <i>versus</i> <br> V-Flex Plus </td> <td> single de novo type A or type B1 lesions 15 mm length in a nativecoronary artery </td> <td> follow-up 12 months<br> n=152/38<br> Parallel groups<br> open <br> Europe </td> </tr> <tr> <td> <a href="index.html"> DELIVER, 2004 </a> <br> </td> <td> non-polymer-based paclitaxel-coated ACHIEVE stent<br>  <i>versus</i> <br> stainless steel Multi-Link (ML) PENTA stent </td> <td> patients with focal de novo coronary lesions, <25 mm in length, in 2.5- to 4.0-mm vessels </td> <td> follow-up 9 months<br> n=524/519<br> Parallel groups<br> single-blind <br> US </td> </tr> <tr> <td> <a href="index.html"> PATENCY, 2002 </a> <br> </td> <td> Logic PTX paclitaxel Eluting CoronaryStents<br>  <i>versus</i> <br> uncoated control stents </td> <td> Patients with de novo lesions of 2.7- to 4.0-mm diameter and 25-mm length received 3.0, 3.5, or 4.0 mm 10- or 15-mm </td> <td> follow-up 9 months<br> n=24/26<br> Parallel groups<br> double blind <br> </td> </tr> <tr> <td> <a href="index.html"> SCORE, 2004 </a> <br> </td> <td> QuaDDS stents (paclitaxel)<br>  <i>versus</i> <br> uncoated control stents </td> <td> patients with focal, de novo coronary lesions </td> <td> follow-up 12 months<br> n=126/140<br> Parallel groups<br> open <br> Worldwide </td> </tr> <tr> <td> <a href="index.html"> ACTION, 2004 </a> <br> </td> <td> Multilink Tetra stent<br>  <i>versus</i> <br> uncoated Multilink Tetra stent </td> <td> Patients with stable angina pectoris orsilent ischemia and a single de novo lesion in a nativecoronary artery >=3.0 mm and <=4.0 mm in diameter thatcould be covered by an 18-mm stent </td> <td> follow-up 6 months<br> n=241/119<br> Parallel groups<br> single-blind <br> worldwide </td> </tr> <tr> <td> <a href="index.html"> FUTURE I, 2004 </a> <br> </td> <td> everolimus coated S-Stent<br>  <i>versus</i> <br> S-Stent </td> <td> de novo coronary lesions </td> <td> follow-up 12 months<br> n=27/15<br> Parallel groups<br> single-blind <br> Germany </td> </tr> <tr> <td> <a href="index.html"> FUTURE II, 2006 </a> <br> </td> <td> CHAMPION<br>  <i>versus</i> <br> bare-metal stent </td> <td> Patients with de novo lesions in vessels with a reference diameter of 2.75-4.0 mm and length  <td> follow-up 6 months<br> n=43/21<br> Parallel groups<br> double-blind <br> NA </td> </tr> <tr> <td> <a href="index.html"> TAXUS V (all patients), 2005 </a> <br> NCT00301522 </td> <td> TAXUS<br>  <i>versus</i> <br> bare metal EXPRESS-2 </td> <td> Stable or unstable AP, silent ischaemia with single coronary artery stenosis including complex or previously unstudied lesions (requiring 2.25-mm, 4.0-mm, and/or multiple stents) </td> <td> follow-up 9 months<br> n=577/579<br> Parallel groups<br> double-blind <br> United States </td> </tr> <tr> <td> <a href="index.html"> TAXUS VI, 2005 </a> <br> NCT00297804 </td> <td> TAXUS<br>  <i>versus</i> <br> Express2 stent </td> <td> Stable or unstable AP, silent ischaemia with long, complex coronary artery lesions </td> <td> follow-up 9 months (2y)<br> n=219/227<br> Parallel groups<br> double-blind <br> Europe </td> </tr> <tr> <td> <a href="index.html"> PASSION, 2006 </a> <br> ISRCTN65027270 </td> <td> Taxus Express2<br>  <i>versus</i> <br> Express2 or Libert� </td> <td> Myocardial Infarction with ST-Segment Elevation </td> <td> follow-up 12 months (5y)<br> n=310/309<br> Parallel groups<br> open <br> The Netherlands </td> </tr> <tr> <td> <a href="index.html"> HAAMU-STENT, 2006 </a> <br> </td> <td> Taxus Express<br>  <i>versus</i> <br> Bare-metal-stent </td> <td> AMI - STEMI patients undergoing PCI </td> <td> follow-up 12 months<br> n=70/75<br> Parallel groups<br> open <br> Finland </td> </tr> <tr> <td> <a href="index.html"> SES-SMART, 2004 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Bx Sonic </td> <td> Stable AP, ACS, silent myocardial ischaemia as shown by exercise stress test </td> <td> follow-up 8 months<br> n=129/128<br> Parallel groups<br> single-blind <br> Italian </td> </tr> <tr> <td> <a href="index.html"> DIABETES, 2005 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Bx Velocity/Sonic </td> <td> de novo lesions in native coronary arteriesin 1, 2, or 3 native vessels with symptoms or objective evidence of ischemia; vessel size smaller than 4.0 mm </td> <td> follow-up 9 months<br> n=80/80<br> Parallel groups<br> open <br> Spanish </td> </tr> <tr> <td> <a href="index.html"> Pache et al, 2005 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> BeStent 2 </td> <td> with symptomatic coronary artery disease and significant angiographic stenosis in native coronary vessels </td> <td> follow-up 12 months<br> n=250/250<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> PRISON II, 2006 </a> <br> NCT00258596 </td> <td> Cypher<br>  <i>versus</i> <br> BxVelocity </td> <td> Chronic total occlusion, positive exercise stress test </td> <td> follow-up 6 months<br> n=100/100<br> Parallel groups<br> single-blind <br> Belgium </td> </tr> <tr> <td> <a href="index.html"> SCANDSTENT, 2006 </a> <br> NCT00151658 </td> <td> Cypher<br>  <i>versus</i> <br> Sonic </td> <td> Stable or unstable AP, recent AMI (non ST-elevation); with one or more de novo complex lesions in native coronary vessels (occluded, bifurcational, ostial or angulated) </td> <td> follow-up 7 months<br> n=163/159<br> Parallel groups<br> open <br> Denmark </td> </tr> <tr> <td> <a href="index.html"> TYPHOON, 2006 </a> <br> NCT00232830 </td> <td> Cypher or CypherSelect<br>  <i>versus</i> <br> any commerciallyavailable uncoated stent </td> <td> AMI </td> <td> follow-up 12 months<br> n=356/359<br> Parallel groups<br> open <br> Worldwide (15 countries) </td> </tr> <tr> <td> <a href="index.html"> SESAMI, 2007 </a> <br> NCT00288210 </td> <td> Cypher<br>  <i>versus</i> <br> BX stent, Cordis </td> <td> AMI </td> <td> follow-up 12 months<br> n=160/160<br> Parallel groups<br> open <br> Italy </td> </tr> <tr> <td> <a href="index.html"> DECODE, 2005 </a> <br> NCT00489164 </td> <td> CYPHER (Up to 3 stents per patient were allowed)<br>  <i>versus</i> <br> Bx VELOCITY (Up to 3 stents per patient were allowed) </td> <td> Stable or unstable angina in diabetic patients with with up to 2 de novo lesions in up to 2 native coronary vessels </td> <td> follow-up 1 year<br> n=54/29<br> Parallel groups<br> open <br> US, Asia/Pacific </td> </tr> <tr> <td> <a href="index.html"> SCORPIUS, 2007 </a> <br> NCT00495898 </td> <td> Cypher<br>  <i>versus</i> <br> Bx-Velocity </td> <td> patients with diabetes and de novo coronary artery lesions </td> <td> follow-up 12 months<br> n=98/102<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> MISSION, 2008 </a> <br> ISRCTN62825862 </td> <td> Cypher<br>  <i>versus</i> <br> Vision </td> <td> primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (<9h) </td> <td> follow-up 12 months<br> n=158/152<br> Parallel groups<br> single-blind <br> the Netherlands </td> </tr> <tr> <td> <a href="index.html"> Ortolani et al, 2007 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Vision </td> <td> symptomatic coronary artery disease and target vessel diameter appropriate for implantation a 3-mm stent </td> <td> follow-up 9 months<br> n=-9/-9<br> Parallel groups<br> single-blind <br> </td> </tr> <tr> <td> <a href="index.html"> TAXi, 2005 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Unselected patients </td> <td> follow-up 6 months<br> n=102/100<br> Parallel groups<br> open <br> Switzerland. </td> </tr> <tr> <td> <a href="index.html"> ISAR-DESIRE (SES vs PES), 2005 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> In-stent restenosis. AP and/or positive test, previously stented, no AMI </td> <td> follow-up 1y<br> n=100/100<br> Parallel groups<br> open <br> germany </td> </tr> <tr> <td> <a href="index.html"> ISAR-DIABETES, 2005 </a> <br> </td> <td> Taxus<br>  <i>versus</i> <br> Cypher </td> <td> Diabetic patients. AP or positive stress, no AMI with clinically significant angiographic stenosis in a native coronary vessel� </td> <td> follow-up 9 months<br> n=125/125<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> SIRTAX (Windecker), 2005 </a> <br> </td> <td> sirolimus-eluting stents (Cypher)<br>  <i>versus</i> <br> paclitaxel-eluting stents (Taxus) </td> <td> Unselected patients. Stable AP, ACS, including AMI. at least one lesion with stenosis of at least 50 percent in a vessel with a reference diameter between 2.25 and 4.00 mm that was suitable for stent implantation </td> <td> follow-up 9 mo (5y)<br> n=503/509<br> Parallel groups<br> single-blind <br> Switzerland </td> </tr> <tr> <td> <a href="index.html"> CORPAL, 2005 </a> <br> </td> <td> sirolimus<br>  <i>versus</i> <br> paclitaxel </td> <td> Documented myocardial ischaemia, no AMI </td> <td> follow-up <br> n=331/321<br> Parallel groups<br> open <br> Spain </td> </tr> <tr> <td> <a href="index.html"> REALITY, 2006 </a> <br> NCT00235092 </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Relatively unselected patients. Stable or unstable documented silent ischaemia, no AMI with 1 or 2 de novo lesions (2.25-3.00 mm in diameter) in native coronary arteries </td> <td> follow-up 12 months<br> n=701/685<br> Parallel groups<br> open <br> Europe, Latin America, and Asiam </td> </tr> <tr> <td> <a href="index.html"> ISAR-SMART 3, 2006 </a> <br> NCT00146575 </td> <td> Taxus<br>  <i>versus</i> <br> Cypher </td> <td> Small vessels, de novo lesions in native coronary vessels with a diameter of <2.80 mm nondiabetic patients. AP or positive stress, no AMI </td> <td> follow-up <br> n=180/180<br> Parallel groups<br> NA <br> Germany </td> </tr> <tr> <td> <a href="index.html"> Zhang (SES vs PES), 2006 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Unselected patients. Stable or unstable AP, ACS with de novo coronary lesions </td> <td> follow-up 1y<br> n=246/203<br> Parallel groups<br> open <br> China </td> </tr> <tr> <td> <a href="index.html"> LONG DES II, 2006 </a> <br> </td> <td> SES<br>  <i>versus</i> <br> PES </td> <td> Long lesions. AP or positive stress, no AMI </td> <td> follow-up 9 months<br> n=250/250<br> Parallel groups<br> single-blind <br> Korea </td> </tr> <tr> <td> <a href="index.html"> PROSIT, 2006 </a> <br> </td> <td> SES Cordis<br>  <i>versus</i> <br> PES Boston Scientific </td> <td> AMI or persistent ischaemia 12-24h </td> <td> follow-up 1 year<br> n=154/154<br> Parallel groups<br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> SORT OUT II, 2008 </a> <br> NCT00388934 </td> <td> Cypher stent<br>  <i>versus</i> <br> Taxus stent(Boston Scientific Corp) </td> <td> Unselected patients (included ST-segment elevation myocardial infarction (STEMI), non-STEMI or unstable angina pectoris, and stable angina) </td> <td> follow-up <br> n=1065/1033<br> Parallel groups<br> open <br> Denmark. </td> </tr> <tr> <td> <a href="index.html"> Cervinka, 2006 </a> <br> </td> <td> sirolimus-eluting stent<br>  <i>versus</i> <br> paclitaxel-eluting stent </td> <td> Complex lesionsand patients. Signs and/or symptoms myocardial ischaemia, including AMI </td> <td> follow-up 6 months<br> n=37/33<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Petronio et al, 2007 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Complex lesions. Stable AP or documented ischaemia, no AMI </td> <td> follow-up 9 months<br> n=50/50<br> Parallel groups<br> open <br> Italy </td> </tr> <tr> <td> <a href="index.html"> Han, 2006 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Multivessel disease. Stable or unstable AP, no AMI </td> <td> follow-up 19.5 months (mean)<br> n=210/206<br> Parallel groups<br> open <br> China </td> </tr> <tr> <td> <a href="index.html"> BASKET (vs paclitaxel), 2005 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Unselected patients; de-novo lesions </td> <td> follow-up 6 months<br> n=264/281<br> Parallel groups<br> open <br> Switzerland, </td> </tr> <tr> <td> <a href="index.html"> Di Lorenzo et al., 2005 </a> <br> </td> <td> sirolimus<br>  <i>versus</i> <br> paclitaxel </td> <td> ST-segment elevation myocardial infarction </td> <td> follow-up <br> n=90/90<br> Parallel groups<br> open <br> NA </td> </tr> <tr> <td> <a href="index.html"> ENDEAVOR II, 2006 </a> <br> </td> <td> AVE Zotarolimus-Eluting Driver<br>  <i>versus</i> <br> Driver </td> <td> single de novo native coronary artery stenosis </td> <td> follow-up 12 months<br> n=598/599<br> Parallel groups<br> double-blind <br> worldwide </td> </tr> <tr> <td> <a href="index.html"> Pasceri, 2003 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> </td> <td> </td> <td> follow-up 12 months<br> n=-9/-9<br> Parallel groups<br> <br> </td> </tr> <tr> <td> <a href="index.html"> SPIRIT I, 2005 </a> <br> NCT00180453 </td> <td> everolimus eluting sent, XIENCE<br>  <i>versus</i> <br> bare etal stent, MULTI-LINK VISION </td> <td> patients with de novo native coronary artery lesions </td> <td> follow-up 6 months (5yr)<br> n=28/32<br> Parallel groups<br> single-blind <br> </td> </tr> <tr> <td> <a href="index.html"> LEADERS, 2008 </a> <br> NCT00389220 </td> <td> BioMatrix III (biolimus-eluting stent withbiodegradable polymer)<br>  <i>versus</i> <br> Cypher SELECT (sirolimus-eluting stent with durable polymer) </td> <td> patients aged 18 years or older with chronic stable coronary artery disease or acute coronary syndromes </td> <td> follow-up 9 months<br> n=857/850<br> Parallel groups<br> open assessor-blind <br> Europe </td> </tr> <tr> <td> <a href="index.html"> GISSOC II, 2010 </a> <br> NCT00220558 </td> <td> Sirolimus Eluting Stent<br>  <i>versus</i> <br> Bare Metal Stent </td> <td> patients with Chronic Total Occlusion older than 1 month, and successful recanalization </td> <td> follow-up 8 months<br> n=78/74<br> Parallel groups<br> open <br> Italy </td> </tr> <tr> <td> <a href="index.html"> SPIRIT II, 2006 </a> <br> NCT00180310 </td> <td> everolimus eluting stent, XIENCE V<br>  <i>versus</i> <br> placitaxel eluting stent, TAXUS EXPRESS2 </td> <td> De novo lesions (maximim two) </td> <td> follow-up 6 months<br> n=223/77<br> Parallel groups<br> single-blind (patient) <br> </td> </tr> <tr> <td> <a href="index.html"> SYNTAX, 2009 </a> <br> NCT00114972 </td> <td> paclitaxel (taxus Express SR)<br>  <i>versus</i> <br> Coronary Artery Bypass Surgery (on- or off-pump bypass) </td> <td> patients with previously untreated three-vessel or left main coronary artery disease (or both) (complex lesions) </td> <td> follow-up 1 year<br> n=903/897<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> ENDEAVOR III, 2006 </a> <br> NCT00217256 </td> <td> ABT-578 coated Endeavor<br>  <i>versus</i> <br> Cypher </td> <td> single de novo lesions in native coronary arteries 2.5-3.5 mm in diameter </td> <td> follow-up 12 months (and 24 months)<br> n=327/109<br> Parallel groups<br> open <br> US </td> </tr> <tr> <td> <a href="index.html"> ENDEAVOR IV, 2009 </a> <br> NCT00217269 </td> <td> zotarolimus-eluting stent (Endeavor)<br>  <i>versus</i> <br> paclitaxel-eluting stent (Taxus) </td> <td> single de novo lesions in native coronary arteries with a reference vessel diameter of 2.5-3.5 mm </td> <td> follow-up mean 36 mo<br> n=773/775<br> Parallel groups<br> open <br> US </td> </tr> <tr> <td> <a href="index.html"> SPIRIT IV, 2010 </a> <br> NCT00307047 </td> <td> XIENCE V Everolimus Eluting Coronary Stent System<br>  <i>versus</i> <br> TAXUS EXPRESS2 Paclitaxel Eluting Coronary Stent System (TAXUS). </td> <td> patients with de novo native coronary artery lesions and reference vessel diameters between 2.5 mm to 4.25 mm and lesion lengths <= 28 mm </td> <td> follow-up 1 y (2y)<br> n=2458/1229<br> Parallel groups<br> 270 days (5 years) <br> USA </td> </tr> <tr> <td> <a href="index.html"> SPIRIT III, 2008 </a> <br> NCT00180479 </td> <td> everolimus-eluting stent, XIENCE V<br>  <i>versus</i> <br> paclitaxel-eluting stent, Taxus </td> <td> lesions 28 mm or less in length and with reference vessel diameter between 2.5 and 3.75 m </td> <td> follow-up 12 months<br> n=669/333<br> Parallel groups<br> single-blind <br> US </td> </tr> <tr> <td> <a href="index.html"> ISAR-TEST-1, 2006 </a> <br> NCT00140530 </td> <td> rapamycin-eluting stent Yukon<br>  <i>versus</i> <br> Taxus </td> <td> stable or unstable anginaor a positive stress test, stable or unstable anginaor a positive stress test </td> <td> follow-up 9 months<br> n=225/225<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> ISAR-LEFT-MAIN, 2009 </a> <br> NCT00133237 </td> <td> Paclitaxel-eluting stent<br>  <i>versus</i> <br> Sirolimus-eluting stent </td> <td> Unprotected Left Main Coronary Artery Disease </td> <td> follow-up 1 year<br> n=302/305<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> SORT OUT IV, 0 </a> <br> NCT00552877 </td> <td> everolimus-eluting stents<br>  <i>versus</i> <br> sirolimus-eluting stents </td> <td> unselected patients with coronary artery disease </td> <td> follow-up 9 months (3 years)<br> n=1390/1384<br> Parallel groups<br> open <br> Denmark </td> </tr> <tr> <td> <a href="index.html"> ZEST (vs SES), 2009 </a> <br> NCT00418067 </td> <td> zotarolimus-eluting stents<br>  <i>versus</i> <br> sirolimus-eluting stents </td> <td> Patients with coronary artery disease </td> <td> follow-up 1 year<br> n=883/878<br> Parallel groups<br> Open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> ZEST AMI (vs PES), 2009 </a> <br> NCT00422565 </td> <td> zotarolimus-eluting stent (Endeavor) <br>  <i>versus</i> <br> paclitaxel-eluting stent (Taxus Libert�) </td> <td> Acute Myocardial Infarction Patients (STEMI)requiring primary angioplasty with symptom onset <= 12 hours </td> <td> follow-up 1 year (mean)<br> n=108/110<br> <br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> Hong, 2005 </a> <br> </td> <td> drug-eluting stents<br>  <i>versus</i> <br> invasive direct coronary artery bypass (MIDCAB) surgery </td> <td> proximal left anterior descending (LAD) coronary artery stenosis </td> <td> follow-up 9 months<br> n=119/70<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Costar II, 2008 </a> <br> NCT00165035 </td> <td> CoStar stent (Conor MedSystems) PES<br>  <i>versus</i> <br> Taxus (Boston Scientific) PES </td> <td> patient undergoing percutaneous coronary intervention for a single lesion per vessel in up to three native epicardial vessels </td> <td> follow-up 8 months (1 year)<br> n=989/686<br> Parallel groups<br> single-blind <br> US, Germany, Belgium, and New Zealand </td> </tr> <tr> <td> <a href="index.html"> TRIAS-HR, 2008 </a> <br> ISRCTN74297220 </td> <td> Genous stent (antibody-coated bare-metal stent) followed by one month of dual antiplatelet therapy<br>  <i>versus</i> <br> Taxus or Cypher followed by at least six months of dual antiplatelet therapy </td> <td> high-risk patients (long lesions, small vessels, chronic total occlusions, or any lesion in a diabetic patient) </td> <td> follow-up 12 months<br> n=98/95<br> Parallel groups<br> single-blind <br> </td> </tr> <tr> <td> <a href="index.html"> Erglis, 2007 </a> <br> </td> <td> IVUS-guided paclitaxel-eluting stent (Taxus Express) after lesion pre-treatment with cutting balloon<br>  <i>versus</i> <br> IVUS-guided bare-metal (Express or Liberte) after lesion pre-treatment with cutting balloon </td> <td> percutaneous coronary intervention for unprotected left main artery stenosis </td> <td> follow-up 6 months<br> n=53/50<br> Parallel groups<br> open <br> NA </td> </tr> <tr> <td> <a href="index.html"> Kim, 2008 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> Korean diabetic patients with high-grade de novo coronary lesions (stenosis of>70 percent of the luminal diameter) requiring <3 stents </td> <td> follow-up 6 months<br> n=85/84<br> Parallel groups<br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> ISAR-DESIRE (SES vs PTCA), 2005 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> ballon angioplasty </td> <td> In-stent restenosis. AP and/or positive test, previously stented, no AMI </td> <td> follow-up 1y<br> n=100/100<br> Parallel groups<br> open <br> germany </td> </tr> <tr> <td> <a href="index.html"> ISAR-DESIRE (PES vs PTCA), 2005 </a> <br> </td> <td> TAXUS<br>  <i>versus</i> <br> ballon angioplasty </td> <td> In-stent restenosis. AP and/or positive test, previously stented, no AMI </td> <td> follow-up 1y<br> n=100/100<br> Parallel groups<br> open <br> germany </td> </tr> <tr> <td> <a href="index.html"> Pan, 2007 </a> <br> </td> <td> SES for provisional T-stenting<br>  <i>versus</i> <br> PES for provisional T-stenting </td> <td> patients with bifurcation lesions </td> <td> follow-up 24 months (mean)<br> n=103/102<br> Parallel groups<br> open <br> Spain </td> </tr> <tr> <td> <a href="index.html"> HORIZONS-AMI Stent, 2008 </a> <br> </td> <td> paclitaxel-eluting stents (Taxus)<br>  <i>versus</i> <br> BMS (Express) </td> <td> ST-elevation myocardial infarction </td> <td> follow-up 1 year<br> n=2257/749<br> Factorial plan<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> ISAR TEST 2 (vs SES), 2009 </a> <br> NCT00332397 </td> <td> dual DES (polymer-free stent consisting of probucol and rapamycin) <br>  <i>versus</i> <br> SES </td> <td> patients with De novo lesions in native coronary arteries </td> <td> follow-up 12 months<br> n=333/335<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> ISAR TEST 2 (vs ZES), 2009 </a> <br> NCT00332397 </td> <td> dual DES (polymer-free stent consisting of probucol and rapamycin)<br>  <i>versus</i> <br> permanent polymer zotarolimus-eluting stent (Endeavor) </td> <td> patients with De novo lesions in native coronary arteries </td> <td> follow-up 12 months<br> n=333/339<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> SORT-OUT-3, 2010 </a> <br> </td> <td> Zotarolimus-eluting stents<br>  <i>versus</i> <br> sirolimus-eluting stents (SES) </td> <td> Patients With Coronary Artery Disease undergoing PCI for any indication </td> <td> follow-up 9 months (18 mo)<br> n=1162/1171<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> ISAR TEST 3 (BP), 2009 </a> <br> </td> <td> biodegradable-polymer 0.4% rapamycin stent (180 mg rapamycin/cm2)<br>  <i>versus</i> <br> permanent-polymer rapamycin-eluting stent (Cypher) (140 mg rapamycin/cm2) </td> <td> Patients with de novo coronary lesions in native vessels </td> <td> follow-up 12 months<br> n=202/202<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> DES-DIABETES, 2008 </a> <br> </td> <td> sirolimus-eluting stent<br>  <i>versus</i> <br> paclitaxel-elutingstent </td> <td> diabetic patients with angina pectoris and/or a positive stress test and a native coronary lesion </td> <td> follow-up 9 months (1 year)<br> n=200/200<br> Factorial plan<br> open <br> Korea </td> </tr> <tr> <td> <a href="index.html"> ISAR TEST 3 (PF), 2009 </a> <br> </td> <td> polymer free 2% rapamycin (479 mg rapamycin/cm2) stent<br>  <i>versus</i> <br> permanent-polymer rapamycin-eluting stent (Cypher) (140 mg rapamycin/cm2) </td> <td> Patients with de novo coronary lesions in native vessels </td> <td> follow-up 12 months<br> n=201/202<br> <br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> GENIUS-STEMI, 2009 </a> <br> </td> <td> endothelial progenitor cell capture stent<br>  <i>versus</i> <br> cobalt chromium stent </td> <td> patients with ST-elevation myocardial infarction </td> <td> follow-up 6 months<br> n=50/50<br> Parallel groups<br> NA <br> </td> </tr> <tr> <td> <a href="index.html"> ZEST (vs PES), 2009 </a> <br> NCT00418067 </td> <td> zotarolimus-eluting stents<br>  <i>versus</i> <br> paclitaxel-eluting stents </td> <td> Patients with coronary artery disease </td> <td> follow-up 1 year<br> n=883/884<br> <br> NA <br> </td> </tr> <tr> <td> <a href="index.html"> Thiele, 2009 </a> <br> NCT00299429 </td> <td> sirolimus-eluting stent<br>  <i>versus</i> <br> MIDCAB surgery </td> <td> isolated LAD disease </td> <td> follow-up 12 months<br> n=65/65<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> PASEO, 2009 </a> <br> </td> <td> paclitaxel-eluting stents and sirolimus-eluting stents<br>  <i>versus</i> <br> bare metal stent </td> <td> patients with ST-elevation myocardial infarction within 12 hours from symptom onset </td> <td> follow-up 4.3 years<br> n=180/90<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> ISAR-TEST-4 (biodegradable polymer), 2009 </a> <br> NCT00598676). </td> <td> biodegradable polymer rapamycin-eluting stent<br>  <i>versus</i> <br> permanent polymer-based rapamycin-eluting or everolimus-eluting </td> <td> patients with stable coronary disease or acute coronary syndromes with de novo native-vessel stent implantation </td> <td> follow-up 12 mo<br> n=1299/1304<br> Parallel groups<br> open <br> Germany </td> </tr> <tr> <td> <a href="index.html"> COMPARE, 2009 </a> <br> NCT01016041 </td> <td> polymer based, everolimus-eluting stent (Xience V)<br>  <i>versus</i> <br> polymer-based, paclitaxel-eluting stent (Taxus Liberte) </td> <td> unselected patients </td> <td> follow-up 1 y (2y)<br> n=897/903<br> Parallel groups<br> open <br> the Netherlands </td> </tr> <tr> <td> <a href="index.html"> DEBATER (SES vs BMS), 2009 </a> <br> </td> <td> sirolimus-eluting stents<br>  <i>versus</i> <br> bare-metal stents </td> <td> patients undergoing PCI for STEMI withon 12 hours </td> <td> follow-up 1 y<br> n=424/446<br> Factorial plan<br> <br> </td> </tr> <tr> <td> <a href="index.html"> RESOLUTE All comers, 2010 </a> <br> NCT00617084.) </td> <td> zotarolimus-eluting stent<br>  <i>versus</i> <br> everolimus-eluting stent (Xience) </td> <td> adult patients with chronic, stable coronary artery disease or acute coronary syndromes, including myocardial infarction with or without ST-segment elevation </td> <td> follow-up 12 months (5y)<br> n=1140/1152<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Boudriot, 2008 </a> <br> </td> <td> DES<br>  <i>versus</i> <br> CABG </td> <td> </td> <td> follow-up 12 months<br> n=83/84<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> BASKET-PROVE (SES), 2010 </a> <br> ISRCTN72444640 </td> <td> first-generation sirolimus-eluting stent <br>  <i>versus</i> <br> BMS </td> <td> patients needing stents 3.0 mm or larger </td> <td> follow-up 2 years<br> n=775/765<br> Parallel groups<br> open <br> Switzerland, Denmark, Austria, Italy </td> </tr> <tr> <td> <a href="index.html"> BASKET-PROVE (EES), 2010 </a> <br> ISRCTN72444640 </td> <td> second generation everolimus-eluting stent<br>  <i>versus</i> <br> BMS </td> <td> patients needing stents 3.0 mm or larger </td> <td> follow-up 2 years<br> n=774/765<br> <br> open <br> Switzerland, Denmark, Austria, Italy </td> </tr> <tr> <td> <a href="index.html"> ISAR-CABG, 0 </a> <br> NCT00611910 </td> <td> DES<br>  <i>versus</i> <br> BMS </td> <td> Bypass Graft Lesions </td> <td> follow-up <br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> PERSEUS Workhorse, 2010 </a> <br> NCT00484315 </td> <td> platinum-chromium alloy, paclitaxel-eluting stent TAXUS Element<br>  <i>versus</i> <br> paclitaxel-eluting stent TAXUS Express 2 </td> <td> De Novo Coronary Artery Lesions; stent patients with lesions <28 mm in length in coronary vessels between 2.75 mm and 4.0 mm in diameter </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> BASKET-SAVAGE, 0 </a> <br> NCT00595647 </td> <td> Taxus<br>  <i>versus</i> <br> Libert� </td> <td> percutaneous coronary interventions of saphenous vein grafts </td> <td> follow-up <br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> DES-ISR, 0 </a> <br> NCT00485030 </td> <td> Cypher<br>  <i>versus</i> <br> Taxus </td> <td> patients Diffuse Type In-Stent Restenosis After Drug-Eluting Stents Implantation </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> FRE-RACE, 0 </a> <br> NCT00130546 </td> <td> Cypher select<br>  <i>versus</i> <br> Taxus </td> <td> de novo native coronary lesions with two or more coronary artery stenoses </td> <td> follow-up <br> n=-9/-9<br> Cross over<br> <br> </td> </tr> <tr> <td> <a href="index.html"> DIABEDES IV, 0 </a> <br> NCT00552994 </td> <td> Cypher select plus<br>  <i>versus</i> <br> Xience V </td> <td> diabetic patients </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> FOCUS, 0 </a> <br> NCT00485004 </td> <td> sirolimus-eluting implantation cypher<br>  <i>versus</i> <br> cutting balloon angioplasty </td> <td> focal in-stent restenosis after drug-eluting stent </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Lipsia-Yukon-DM, 0 </a> <br> NCT00368953 </td> <td> Yukon Choice stent system<br>  <i>versus</i> <br> Taxus Libert� stent system </td> <td> Patients With Diabetes Mellitus </td> <td> follow-up 9 months<br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Nordic Bifurcation Study, 0 </a> <br> NCT00376571 </td> <td> Strategy of Routine Stenting Both Main Vessel and Side Branch<br>  <i>versus</i> <br> Strategy of Routine Main Vessel Stenting and Optional Treatment of Side Branch </td> <td> bifurcation lesions </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> LEFT-MAIN-2, 0 </a> <br> NCT00598637 </td> <td> Xience<br>  <i>versus</i> <br> Endeavor Resolute </td> <td> unprotected left main coronary artery disease </td> <td> follow-up <br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> VELETI, 0 </a> <br> NCT00289835 </td> <td> TAXUS<br>  <i>versus</i> <br> standard medical treatment </td> <td> Moderate Vein Graft Lesions </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Leipzig, 0 </a> <br> NCT00176397 </td> <td> PCI With DES<br>  <i>versus</i> <br> CABG </td> <td> left main coronary stenosis </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> ZoMaxx phase 2, 0 </a> <br> NCT00140101 </td> <td> ZoMaxx drug-eluting stent<br>  <i>versus</i> <br> TAXUS Express2 </td> <td> de Novo Coronary Artery Lesions </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> PEPCAD IV, 0 </a> <br> NCT00462631 </td> <td> Paclitaxel-eluting PTCA-balloon dilation (SeQuentTM Please) followed by cobalt-chromium stent (CoroflexTM Blue) deployment<br>  <i>versus</i> <br> Taxus Libert� </td> <td> patients with diabetes mellitus </td> <td> follow-up <br> n=-9/-9<br> <br> open <br> </td> </tr> <tr> <td> <a href="index.html"> Nordic Bifurcation Stent Technique Study, 0 </a> <br> NCT00292305 </td> <td> crush stenting<br>  <i>versus</i> <br> culotte stenting </td> <td> bifurcation lesions </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> PROTECT, 0 </a> <br> NCT00476957 </td> <td> Medtronic Endeavor Zotarolimus Eluting Coronary Stent System<br>  <i>versus</i> <br> Cordis Cypher Sirolimus-eluting Coronary Stent </td> <td> unselected patients </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> MIDCAB Versus DES in Proximal LAD Lesions, 0 </a> <br> NCT00299429 </td> <td> sirolimus-coated stent<br>  <i>versus</i> <br> minimally invasive bypass surgery </td> <td> patients with isolated proximal left anterior descending coronary arteries </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> PRISON III, 2007 </a> <br> NCT00428454 </td> <td> Endeavor<br>  <i>versus</i> <br> Cypher </td> <td> patients with total coronary occlusions for at least 2 weeks with evidence of ischemia related to the occluded coronary artery </td> <td> follow-up 8 months<br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> FEMH-93005, 0 </a> <br> NCT00190099 </td> <td> <br>  <i>versus</i> <br> </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> GENESIS Trial CP-01, 0 </a> <br> NCT00322569 </td> <td> Corio Pimecrolimus<br>  <i>versus</i> <br> CoStar </td> <td> patients with de novo lesions of the native coronary arteries </td> <td> follow-up 6 months<br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> FREEDOM, 0 </a> <br> NCT00086450 </td> <td> percutaneous coronary stenting<br>  <i>versus</i> <br> CABG </td> <td> diabetic individuals with multivessel coronary artery disease </td> <td> follow-up 5 years<br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> TRIAS-Low-Risk , 0 </a> <br> </td> <td> <br>  <i>versus</i> <br> </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> COMBAT, 0 </a> <br> </td> <td> PCI<br>  <i>versus</i> <br> CABG </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Korean Randomized Study, 0 </a> <br> </td> <td> PCI<br>  <i>versus</i> <br> CABG </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Munich Study, 0 </a> <br> </td> <td> sirolimus<br>  <i>versus</i> <br> CABG </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> REVASCULARIZE, 0 </a> <br> </td> <td> PCI<br>  <i>versus</i> <br> CABG </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> VA CARDS, 0 </a> <br> NCT00326196 </td> <td> percutaneous coronary stenting with drug eluding stents<br>  <i>versus</i> <br> CABG </td> <td> angiographically significant coronary artery disease in diabetes </td> <td> follow-up <br> n=-9/-9<br> Parallel groups<br> open <br> </td> </tr> <tr> <td> <a href="index.html"> BASKET-PROVE, 2008 </a> <br> </td> <td> Cypher<br>  <i>versus</i> <br> Vision </td> <td> </td> <td> follow-up <br> n=-9/-9<br> <br> <br> </td> </tr> <tr> <td> <a href="index.html"> Gao, </a> <br> NCT00887211 </td> <td> ProStent rapamycin-eluting stent system<br>  <i>versus</i> <br> Firebird drug-eluting stents </td> <td> </td> <td> follow-up <br> n=-9/-9<br> Parallel groups<br> single blind <br> </td> </tr> </table> <h2>References</h2> <p> <b>Tomai, 2008 : </b> Tomai F, Reimers B, De Luca L, Galassi AR, Gaspardone A, Ghini AS, Ferrero V, Favero L, Gioffr G, Prati F, Tamburino C, Ribichini F, Head-to-head comparison of sirolimus- and paclitaxel-eluting stent in the same diabetic patient with multiple coronary artery lesions: a prospective, randomized, multicenter study. <i>Diabetes Care 2008;31:15-9.</i> [PMID 17909090] 10.2337/dc07-1377 </p> <p> <b>Kochiadakis, 2007 : </b> Kochiadakis GE, Marketou ME, Arfanakis DA, Sfiridaki K, Skalidis EI, Igoumenidis NE, Hamilos MI, Kolyvaki S, Chlouverakis G, Kantidaki E, Castanas E, Vardas PE, Reduced systemic inflammatory response to implantation of sirolimus-eluting stents in patients with stable coronary artery disease. <i>Atherosclerosis 2007;194:433-8.</i> [PMID 16997310] 10.1016/j.atherosclerosis.2006.08.029 </p> <p> <b>RAVEL, 2002 : </b> Morice MC, Serruys PW, Sousa JE, Fajadet J, Ban Hayashi E, Perin M, Colombo A, Schuler G, Barragan P, Guagliumi G, Molnr F, Falotico RA randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. <i>N Engl J Med 2002;346:1773-80</i> [PMID 12050336] </p> <p> <b>RAVEL, 2002 : </b> Morice MC, Serruys PW, Barragan P, Bode C, Van Es GA, Stoll HP, Snead D, Mauri L, Cutlip DE, Sousa ELong-term clinical outcomes with sirolimus-eluting coronary stents: five-year results of the RAVEL trial. <i>J Am Coll Cardiol 2007 Oct 2;50:1299-304</i> [PMID 17903626] </p> <p> <b>SIRIUS, 2003 : </b> Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RESirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. <i>N Engl J Med 2003;349:1315-23</i> [PMID 14523139] </p> <p> <b>SIRIUS, 2003 : </b> Weisz G, Moses JW, Teirstein PS, Holmes DR Jr, Raizner AE, Satler LF, Mishkel G, Wilensky RL, Wang P, Kuntz RE, Popma JJ, Leon MBSafety of sirolimus-eluting stenting and its effect on restenosis in patients with unstable angina pectoris (a SIRIUS substudy). <i>Am J Cardiol 2007 Apr 15;99:1044-50</i> [PMID 17437725] </p> <p> <b>SIRIUS, 2003 : </b> Holmes DR Jr, Leon MB, Moses JW, Popma JJ, Cutlip D, Fitzgerald PJ, Brown C, Fischell T, Wong SC, Midei M, Snead D, Kuntz REAnalysis of 1-year clinical outcomes in the SIRIUS trial: a randomized trial of a sirolimus-eluting stent versus a standard stent in patients at high risk for coronary restenosis. <i>Circulation 2004;109:634-40</i> [PMID 14769686] </p> <p> <b>SIRIUS, 2003 : </b> Weisz G, Leon MB, Holmes DR Jr, Kereiakes DJ, Popma JJ, Teirstein PS, Cohen SA, Wang H, Cutlip DE, Moses JWFive-year follow-up after sirolimus-eluting stent implantation results of the SIRIUS (Sirolimus-Eluting Stent in De-Novo Native Coronary Lesions) Trial. <i>J Am Coll Cardiol 2009 Apr 28;53:1488-97</i> [PMID 19389558] 10.1016/j.jacc.2009.01.050 </p> <p> <b>SIRIUS, 2003 : </b> Novack V, Nguyen MC, Rooney M, Chacko R, Novack L, Pencina M, Apruzzese P, Mauri L, Cohen SA, Moses J, Leon MB, Cutlip DEEffect of coronary target lesion revascularization on late cardiac events after insertion of sirolimus-eluting or bare metal stents. <i>Am J Cardiol 2010 Sep 15;106:774-9</i> [PMID 20816116] 10.1016/j.amjcard.2010.04.039 </p> <p> <b>C-SIRIUS, 2004 : </b> Schampaert E, Cohen EA, Schlter M, Reeves F, Traboulsi M, Title LM, Kuntz RE, Popma JJThe Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries (C-SIRIUS). <i>J Am Coll Cardiol 2004;43:1110-5</i> [PMID 15028375] </p> <p> <b>E-SIRIUS, 2003 : </b> Schofer J, Schlter M, Gershlick AH, Wijns W, Garcia E, Schampaert E, Breithardt GSirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial (E-SIRIUS). <i>Lancet 2003;362:1093-9</i> [PMID 14550694] </p> <p> <b>TAXUS I, 2003 : </b> Grube E, Silber S, Hauptmann KE, Mueller R, Buellesfeld L, Gerckens U, Russell METAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions. <i>Circulation 2003;107:38-42</i> [PMID 12515740] </p> <p> <b>TAXUS I, 2003 : </b> Grube E, Silber S, Hauptmann KE, Mueller R, Buellesfeld L, Gerckens U, Russell METAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions. <i>Circulation 2003 Jan 7;107:38-42</i> [PMID 12515740] </p> <p> <b>TAXUS II, 2003 : </b> Colombo A, Drzewiecki J, Banning A, Grube E, Hauptmann K, Silber S, Dudek D, Fort S, Schiele F, Zmudka K, Guagliumi G, Russell MERandomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions. <i>Circulation 2003;108:788-94</i> [PMID 12900339] </p> <p> <b>TAXUS II, 2003 : </b> Silber S, Colombo A, Banning AP, Hauptmann K, Drzewiecki J, Grube E, Dudek D, Baim DSFinal 5-year results of the TAXUS II trial: a randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for de novo coronary artery lesions. <i>Circulation 2009 Oct 13;120:1498-504</i> [PMID 19786634] </p> <p> <b>TAXUS IV, 2004 : </b> Stone GW, Ellis SG, Cox DA, Hermiller J, O'Shaughnessy C, Mann JT, Turco M, Caputo R, Bergin P, Greenberg J, Popma JJ, Russell MEA polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. <i>N Engl J Med 2004;350:221-31</i> [PMID 14724301] </p> <p> <b>TAXUS IV, 2004 : </b> Ellis SG, Stone GW, Cox DA, Hermiller J, O'Shaughnessy C, Mann T, Turco M, Caputo R, Bergin PJ, Bowman TS, Baim DSLong-Term Safety and Efficacy With Paclitaxel-Eluting Stents 5-Year Final Results of the TAXUS IV Clinical Trial (TAXUS IV-SR: Treatment of De Novo Coronary Disease Using a Single Paclitaxel-Eluting Stent). <i>JACC Cardiovasc Interv 2009 Dec;2:1248-59</i> [PMID 20129552] 10.1016/j.jcin.2009.10.003 </p> <p> <b>TAXUS IV, 2004 : </b> Ellis SG, Stone GW, Cox DA, Hermiller J, O'Shaughnessy C, Mann T, Turco M, Caputo R, Bergin PJ, Bowman TS, Baim DSLong-term safety and efficacy with paclitaxel-eluting stents: 5-year final results of the TAXUS IV clinical trial (TAXUS IV-SR: Treatment of De Novo Coronary Disease Using a Single Paclitaxel-Eluting Stent). <i>JACC Cardiovasc Interv 2009;2:1248-59</i> [PMID 20129552] 10.1016/j.jcin.2009.10.003 </p> <p> <b>ASPECT, 2003 : </b> Park SJ, Shim WH, Ho DS, Raizner AE, Park SW, Hong MK, Lee CW, Choi D, Jang Y, Lam R, Weissman NJ, Mintz GSA paclitaxel-eluting stent for the prevention of coronary restenosis. <i>N Engl J Med 2003;348:1537-45</i> [PMID 12700373] </p> <p> <b>ELUTES, 2004 : </b> Gershlick A, De Scheerder I, Chevalier B, Stephens-Lloyd A, Camenzind E, Vrints C, Reifart N, Missault L, Goy JJ, Brinker JA, Raizner AE, Urban P, Heldman AWInhibition of restenosis with a paclitaxel-eluting, polymer-free coronary stent: the European evaLUation of pacliTaxel Eluting Stent (ELUTES) trial. <i>Circulation 2004;109:487-93</i> [PMID 14744971] </p> <p> <b>DELIVER, 2004 : </b> ONeill WW, Knopf W, Lansky A, Fitzgerald P, Mahaffey K.Randomized comparison of paclitaxel-coated versus metallic stentsfor treatment of coronary lesions <i>American College of CardiologyScientific Session, March, 2003</i> [PMID ] </p> <p> <b>DELIVER, 2004 : </b> Knopf W, ONeill WW, Lansky A, Fitzgerald P, Mahaffey KERandomized comparison of paclitaxel-coated versus metallicstents for treatment of coronary lesions <i>TranscatheterCardiovascular Therapeutics Annual Meeting, September, 2003</i> [PMID ] </p> <p> <b>DELIVER, 2004 : </b> Lansky AJ, Costa RA, Mintz GS, Tsuchiya Y, Midei M, Cox DA, O'Shaughnessy C, Applegate RA, Cannon LA, Mooney M, Farah A, Tannenbaum MA, Yakubov S, Kereiakes DJ, Wong SC, Kaplan B, Cristea E, Stone GW, Leon MB, Knopf WD, O'Neill WWNon-polymer-based paclitaxel-coated coronary stents for the treatment of patients with de novo coronary lesions: angiographic follow-up of the DELIVER clinical trial. <i>Circulation 2004 Apr 27;109:1948-54</i> [PMID 15078794] </p> <p> <b>PATENCY, 2002 : </b> Heldman A, Farhat N, Fry E, et al.bPaclitaxel-eluting stent for cytostatic prevention of restenosis: the PATENCY Study <i>Transcatheter Cardiovascular Therapeutics Annual Meeting,September, 2002</i> [PMID ] </p> <p> <b>SCORE, 2004 : </b> Stone GW.Adverse outcomes from a taxane-loaded polymericsleeved stent: final results from the SCORE Tria <i>AmericanCollege of Cardiology Scientific Session, March, 2002</i> [PMID ] </p> <p> <b>SCORE, 2004 : </b> Grube E, Lansky A, Hauptmann KE, Di Mario C, Di Sciascio G, Colombo A, Silber S, Stumpf J, Reifart N, Fajadet J, Marzocchi A, Schofer J, Dumas P, Hoffmann R, Guagliumi G, Pitney M, Russell MEHigh-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularization: one-year results from the SCORE randomized trial. <i>J Am Coll Cardiol 2004 Oct 6;44:1368-72</i> [PMID 15464315] </p> <p> <b>ACTION, 2004 : </b> Serruys PW, Veldhof S, Stuteville M, et alActinomycin-elutingstent improves outcome by reducing neointimal hyperplasia <i>Transcatheter Cardiovascular Therapeutics Annual Meeting,September, 2002</i> [PMID ] </p> <p> <b>ACTION, 2004 : </b> Serruys PW, Ormiston JA, Sianos G, Sousa JE, Grube E, den Heijer P, de Feyter P, Buszman P, Schmig A, Marco J, Polonski L, Thuesen L, Zeiher AM, Bett JH, Suttorp MJ, Glogar HD, Pitney M, Wilkins GT, Whitbourn R, Veldhof S, Miquel K, Johnson R, Coleman L,Actinomycin-eluting stent for coronary revascularization: a randomized feasibility and safety study: the ACTION trial. <i>J Am Coll Cardiol 2004 Oct 6;44:1363-7</i> [PMID 15464314] </p> <p> <b>FUTURE I, 2004 : </b> Grube E, Sonoda S, Ikeno F, Honda Y, Kar S, Chan C, Gerckens U, Lansky AJ, Fitzgerald PJSix- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. <i>Circulation 2004;109:2168-71</i> [PMID 15123533] </p> <p> <b>FUTURE II, 2006 : </b> Grube E, Lansky A, Mehran R, Fitzgerald P, HoMulticenter evaluation of the bioabsorbable polymer-basedeverolimus-eluting stent: FUTURE-2 trial <i>TranscatheterCardiovascular Therapeutic Annual Meeting, September, 2003</i> [PMID ] </p> <p> <b>FUTURE II, 2006 : </b> Tsuchiya Y, Lansky AJ, Costa RA, Mehran R, Pietras C, Shimada Y, Sonoda S, Cristea E, Negoita M, Dangas GD, Moses JW, Leon MB, Fitzgerald PJ, Mller R, Strger H, Hauptmann KE, Grube EEffect of everolimus-eluting stents in different vessel sizes (from the pooled FUTURE I and II trials). <i>Am J Cardiol 2006 Aug 15;98:464-9</i> [PMID 16893698] </p> <p> <b>FUTURE II, 2006 : </b> Grube E, Sonoda S, Ikeno F, Honda Y, Kar S, Chan C, Gerckens U, Lansky AJ, Fitzgerald PJSix- and twelve-month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. <i>Circulation 2004 May 11;109:2168-71</i> [PMID 15123533] </p> <p> <b>TAXUS V (all patients), 2005 : </b> Stone GW, Ellis SG, Cannon L, Mann JT, Greenberg JD, Spriggs D, O'Shaughnessy CD, DeMaio S, Hall P, Popma JJ, Koglin J, Russell MEComparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial. <i>JAMA 2005;294:1215-23</i> [PMID 16160130] </p> <p> <b>TAXUS VI, 2005 : </b> Dawkins KD, Grube E, Guagliumi G, Banning AP, Zmudka K, Colombo A, Thuesen L, Hauptman K, Marco J, Wijns W, Popma JJ, Koglin J, Russell MEClinical efficacy of polymer-based paclitaxel-eluting stents in the treatment of complex, long coronary artery lesions from a multicenter, randomized trial: support for the use of drug-eluting stents in contemporary clinical practice. <i>Circulation 2005;112:3306-13</i> [PMID 16286586] </p> <p> <b>TAXUS VI, 2005 : </b> Grube E, Dawkins KD, Guagliumi G, Banning AP, Zmudka K, Colombo A, Thuesen L, Hauptman K, Marco J, Wijns W, Popma JJ, Buellesfeld L, Koglin J, Russell METAXUS VI 2-year follow-up: randomized comparison of polymer-based paclitaxel-eluting with bare metal stents for treatment of long, complex lesions. <i>Eur Heart J 2007;28:2578-82</i> [PMID 17938126] </p> <p> <b>TAXUS VI, 2005 : </b> Grube E, Dawkins K, Guagliumi G, Banning A, Zmudka K, Colombo A, Thuesen L, Hauptman K, Marco J, Wijns W, Joshi A, Mascioli STAXUS VI final 5-year results: a multicentre, randomised trial comparing polymer-based moderate-release paclitaxel-eluting stent with a bare metal stent for treatment of long, complex coronary artery lesions. <i>EuroIntervention 2009;4:572-7</i> [PMID 19378676] </p> <p> <b>PASSION, 2006 : </b> Laarman GJ, Suttorp MJ, Dirksen MT, van Heerebeek L, Kiemeneij F, Slagboom T, van der Wieken LR, Tijssen JG, Rensing BJ, Patterson MPaclitaxel-eluting versus uncoated stents in primary percutaneous coronary intervention. <i>N Engl J Med 2006;355:1105-13</i> [PMID 16971717] </p> <p> <b>PASSION, 2006 : </b> Dirksen MT, Vink MA, Suttorp MJ, Tijssen JG, Patterson MS, Slagboom T, Kiemeneij F, Laarman GJ <i>EuroIntervention 2008 May;4:64-70</i> [PMID 19112781] </p> <p> <b>HAAMU-STENT, 2006 : </b> Tierala I, Syvaenne M, Kupari MRandomised comparison of apaclitaxel-eluting and a bare metal stent in STEMI-PCI. TheHAAMU-STENT-study <i>Annual Scientifi c Meeting of theTranscatheter Cardiovascular Therapeutics; Washington, DC;Oct 2227, 2006. Abstract 178.</i> [PMID ] </p> <p> <b>SES-SMART, 2004 : </b> Ardissino D, Cavallini C, Bramucci E, Indolfi C, Marzocchi A, Manari A, Angeloni G, Carosio G, Bonizzoni E, Colusso S, Repetto M, Merlini PASirolimus-eluting vs uncoated stents for prevention of restenosis in small coronary arteries: a randomized trial. <i>JAMA 2004;292:2727-34</i> [PMID 15585732] </p> <p> <b>DIABETES, 2005 : </b> Sabat M, Jimnez-Quevedo P, Angiolillo DJ, Gmez-Hospital JA, Alfonso F, Hernndez-Antoln R, Goicolea J, Bauelos C, Escaned J, Moreno R, Fernndez C, Fernndez-Avils F, Macaya CRandomized comparison of sirolimus-eluting stent versus standard stent for percutaneous coronary revascularization in diabetic patients: the diabetes and sirolimus-eluting stent (DIABETES) trial. <i>Circulation 2005;112:2175-83</i> [PMID 16203930] </p> <p> <b>DIABETES, 2005 : </b> Jimnez-Quevedo P, Sabat M, Angiolillo DJ, Alfonso F, Hernndez-Antoln R, SanMartn M, Gmez-Hospital JA, Bauelos C, Escaned J, Moreno R, Fernndez C, Fernndez-Avils F, Macaya CLong-term clinical benefit of sirolimus-eluting stent implantation in diabetic patients with de novo coronary stenoses: long-term results of the DIABETES trial. <i>Eur Heart J 2007;28:1946-52</i> [PMID 17562666] </p> <p> <b>DIABETES, 2005 : </b> Maeng M, Jensen LO, Galloe AM, Thayssen P, Christiansen EH, Hansen KN, Helqvist S, Botker HE, Lassen JF, Thuesen L <i>Am J Cardiol 2009 Feb 1;103:345-9</i> [PMID 19166687] </p> <p> <b>Pache et al, 2005 : </b> Pache J, Dibra A, Mehilli J, Dirschinger J, Schmig A, Kastrati ADrug-eluting stents compared with thin-strut bare stents for the reduction of restenosis: a prospective, randomized trial. <i>Eur Heart J 2005;26:1262-8</i> [PMID 15737962] </p> <p> <b>PRISON II, 2006 : </b> Suttorp MJ, Laarman GJ, Rahel BM, Kelder JC, Bosschaert MA, Kiemeneij F, Ten Berg JM, Bal ET, Rensing BJ, Eefting FD, Mast EGPrimary Stenting of Totally Occluded Native Coronary Arteries II (PRISON II): a randomized comparison of bare metal stent implantation with sirolimus-eluting stent implantation for the treatment of total coronary occlusions. <i>Circulation 2006;114:921-8</i> [PMID 16908768] </p> <p> <b>SCANDSTENT, 2006 : </b> Kelbaek H, Thuesen L, Helqvist S, Klvgaard L, Jrgensen E, Aljabbari S, Saunamki K, Krusell LR, Jensen GV, Btker HE, Lassen JF, Andersen HR, Thayssen P, Galle A, van Weert AThe Stenting Coronary Arteries in Non-stress/benestent Disease (SCANDSTENT) trial. <i>J Am Coll Cardiol 2006;47:449-55</i> [PMID 16412876] </p> <p> <b>SCANDSTENT, 2006 : </b> Kelbaek H, Klvgaard L, Helqvist S, Lassen JF, Krusell LR, Engstrm T, Btker HE, Jrgensen E, Saunamki K, Aljabbari S, Thayssen P, Galle A, Jensen GV, Thuesen LLong-term outcome in patients treated with sirolimus-eluting stents in complex coronary artery lesions: 3-year results of the SCANDSTENT (Stenting Coronary Arteries in Non-Stress/Benestent Disease) trial. <i>J Am Coll Cardiol 2008 May 27;51:2011-6</i> [PMID 18498953] </p> <p> <b>TYPHOON, 2006 : </b> Spaulding C, Henry P, Teiger E, Beatt K, Bramucci E, Carri D, Slama MS, Merkely B, Erglis A, Margheri M, Varenne O, Cebrian A, Stoll HP, Snead DB, Bode CSirolimus-eluting versus uncoated stents in acute myocardial infarction. <i>N Engl J Med 2006;355:1093-104</i> [PMID 16971716] </p> <p> <b>SESAMI, 2007 : </b> Menichelli M, Parma A, Pucci E, Fiorilli R, De Felice F, Nazzaro M, Giulivi A, Alborino D, Azzellino A, Violini RRandomized trial of Sirolimus-Eluting Stent Versus Bare-Metal Stent in Acute Myocardial Infarction (SESAMI). <i>J Am Coll Cardiol 2007;49:1924-30</i> [PMID 17498576] </p> <p> <b>SESAMI, 2007 : </b> Violini R, Musto C, De Felice F, Nazzaro MS, Cifarelli A, Petitti T, Fiorilli RMaintenance of Long-Term Clinical Benefit With Sirolimus-Eluting Stents in Patients With ST-Segment Elevation Myocardial Infarction 3-Year Results of the SESAMI (Sirolimus-Eluting Stent Versus Bare-Metal Stent In Acute Myocardial Infarction) Trial. <i>J Am Coll Cardiol 2010 Feb 23;55:810-814</i> [PMID 20170821] 10.1016/j.jacc.2009.09.046 </p> <p> <b>DECODE, 2005 : </b> Chan C, Zambahari R, Kaul U, Cohen SA, Buchbinder M.Outcomesin diabetic patients with multivessel disease and long lesions: resultsfrom the DECODE study <i>Am J Cardiol 2005; 96 (suppl 7A): 31H</i> [PMID ] </p> <p> <b>SCORPIUS, 2007 : </b> Baumgart D.One year results of the SCORPIUS-Trial - a Germanmulticenter investigation on the eff ectiveness of sirolimus-elutingstents in diabetic patients <i>Annual Scientifi c Meeting of theTranscatheter Cardiovascular Therapeutics. Washington, DC;Oct 2227, 2006. Abstract 288.</i> [PMID ] </p> <p> <b>SCORPIUS, 2007 : </b> Baumgart D, Klauss V, Baer F, Hartmann F, Drexler H, Motz W, Klues H, Hofmann S, Vlker W, Pfannebecker T, Stoll HP, Nickenig GOne-year results of the SCORPIUS study: a German multicenter investigation on the effectiveness of sirolimus-eluting stents in diabetic patients. <i>J Am Coll Cardiol 2007 Oct 23;50:1627-34</i> [PMID 17950142] </p> <p> <b>MISSION, 2008 : </b> van der Hoeven BL, Liem S, Jukema JW, et al.Prospectiverandomised trial to evaluate the effi cacy and safety of drug-elutingstents versus barem-metal stents for the treatment of acutemyocardial infarction (the MISSION! intervention study) <i>AnnualScientifi c Meeting of the American Heart Association. Chicago, IL,USA; Nov 1215, 2006.</i> [PMID ] </p> <p> <b>MISSION, 2008 : </b> van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJSirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study. <i>J Am Coll Cardiol 2008 Feb 12;51:618-26</i> [PMID 18261680] </p> <p> <b>Ortolani et al, 2007 : </b> Ortolani P, Marzocchi A, Marrozzini C, Palmerini T, Saia F, Taglieri N, Aquilina M, Baldazzi F, Silenzi S, Cooke RM, Reggiani ML, Branzi ARandomized comparative trial of a thin-strut bare metal cobalt-chromium stent versus a sirolimus-eluting stent for coronary revascularization. <i>Catheter Cardiovasc Interv 2007;69:790-8</i> [PMID 17290437] </p> <p> <b>TAXi, 2005 : </b> Goy JJ, Stauffer JC, Siegenthaler M, Benot A, Seydoux CA prospective randomized comparison between paclitaxel and sirolimus stents in the real world of interventional cardiology: the TAXi trial. <i>J Am Coll Cardiol 2005;45:308-11</i> [PMID 15653032] </p> <p> <b>TAXi, 2005 : </b> Berger A, Stauffer JC, Seydoux C, Siegenthaler M, Benot A, Goy JJThree-year follow-up of the first prospective randomized comparison between paclitaxel and sirolimus stents: the TAXi-LATE trial. <i>Catheter Cardiovasc Interv 2007 Aug 1;70:163-6</i> [PMID 17630653] </p> <p> <b>ISAR-DESIRE (SES vs PES), 2005 : </b> Kastrati A, Mehilli J, von Beckerath N, Dibra A, Hausleiter J, Pache J, Schhlen H, Schmitt C, Dirschinger J, Schmig ASirolimus-eluting stent or paclitaxel-eluting stent vs balloon angioplasty for prevention of recurrences in patients with coronary in-stent restenosis: a randomized controlled trial. <i>JAMA 2005;293:165-71</i> [PMID 15644543] </p> <p> <b>ISAR-DIABETES, 2005 : </b> Dibra A, Kastrati A, Mehilli J, Pache J, Schhlen H, von Beckerath N, Ulm K, Wessely R, Dirschinger J, Schmig APaclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients. <i>N Engl J Med 2005;353:663-70</i> [PMID 16105990] </p> <p> <b>SIRTAX (Windecker), 2005 : </b> Windecker S, Remondino A, Eberli FR, Jni P, Rber L, Wenaweser P, Togni M, Billinger M, Tller D, Seiler C, Roffi M, Corti R, Stsch G, Maier W, Lscher T, Hess OM, Egger M, Meier BSirolimus-eluting and paclitaxel-eluting stents for coronary revascularization. <i>N Engl J Med 2005;353:653-62</i> [PMID 16105989] </p> <p> <b>CORPAL, 2005 : </b> de Lezo J, Medina A, Pan M, et al.de Lezo J, Medina A, Pan M, et al. 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Zeiher AM, Grube E, Haase J, Thuesen L, Hamm CW, Veldhof S, Dorange C, Serruys PWOne-year results of a durable polymer everolimus-eluting stent in de novo coronary narrowings (The SPIRIT FIRST Trial). <i>EuroIntervention 2005 Nov;1:266-72</i> [PMID 19758915] </p> <p> <b>SPIRIT I, 2005 : </b> Tsuchida K, Garca-Garca HM, Ong AT, Valgimigli M, Aoki J, Rademaker TA, Morel MA, van Es GA, Bruining N, Serruys PWRevisiting late loss and neointimal volumetric measurements in a drug-eluting stent trial: analysis from the SPIRIT FIRST trial. <i>Catheter Cardiovasc Interv 2006 Feb;67:188-97</i> [PMID 16400664] </p> <p> <b>PERSEUS Workhorse, 2010 : </b> Allocco DJ, Cannon LA, Britt A, Heil JE, Nersesov A, Wehrenberg S, Dawkins KD, Kereiakes DJA prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: design and statistical methods of the PERSEUS clinical program. <i>Trials 2010 Jan 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sirolimus-eluting and bare metal stent for treatment of patients with total coronary occlusions: results of the GISSOC II-GISE multicentre randomized trial. <i>Eur Heart J 2010;:</i> [PMID 20566487] 10.1093/eurheartj/ehq199 </p> <p> <b>SPIRIT II, 2006 : </b> Garg S, Serruys P, Onuma Y, Dorange C, Veldhof S, Miquel-H�bert K, Sudhir K, Boland J, Huber K, Garcia E, Te Riele JA3-Year Clinical Follow-Up of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients With De Novo Coronary Artery Lesions The SPIRIT II Trial (Clinical Evaluation of the Xience V Everolimus Eluting Coronary Stent System in the Treatment of Patients with de novo Native Coronary Artery Lesions). <i>JACC Cardiovasc Interv 2009 Dec;2:1190-8</i> [PMID 20129545] 10.1016/j.jcin.2009.10.002 </p> <p> <b>SPIRIT II, 2006 : </b> Onuma Y, Tanimoto S, Ruygrok P, Neuzner J, Piek JJ, Seth A, Schofer JJ, Richardt G, Wiemer M, Carri� D, Thuesen L, Dorange C, Miquel-Hebert K, Veldhof S, Serruys PWEfficacy of 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