DVT prophylaxis - new oral anticoagulant - elective major knee surgery clinical trials results meta-analysis

<h1> <a href="index.html"> <strong>DVT prophylaxis</strong> - new oral anticoagulant </a> - elective major knee surgery trial results systematic overview and meta-analysis </h1> <h2>Main characteristics of the included studies</h2> <table> <tr> <th>Trial</th> <th>Treatments</th> <th>Patients</th> <th>Methods</th> </tr> <tr> <td> <a href="index.html"> RE-MOBILIZE (220mg), 2008 </a> <br> </td> <td> dabigatran etexilate 220 mg for 12-15 days <br>  <i>versus</i> <br> Enoxaparin 30 BID </td> <td> Total knee replacement </td> <td> follow-up 12-15 days, median 14d<br> n=862/876<br> <br> double blind <br> US, Canada, Mexico, UK </td> </tr> <tr> <td> <a href="index.html"> RE-MODEL (220mg), 2007 </a> <br> </td> <td> dabigatran etexilate 220 mg q.d. 6-10 days <br>  <i>versus</i> <br> Enoxaparin 40 mg q.d. </td> <td> Total knee replacement </td> <td> follow-up 6-10 days, mean 8 days<br> n=694/699<br> <br> double blind <br> Europe, Australia, South Africa </td> </tr> <tr> <td> <a href="index.html"> RE-MODEL (150mg), 2007 </a> <br> </td> <td> dabigatran etexilate 150 mg q.d. for 6-10 days<br>  <i>versus</i> <br> Enoxaparin 40 mg q.d. </td> <td> Total knee replacement </td> <td> follow-up 6-10 days, mean 8 days<br> n=708/699<br> Parallel groups<br> double blind <br> Europe, Australia, South Africa </td> </tr> <tr> <td> <a href="index.html"> RE-MOBILIZE (150mg), 2008 </a> <br> </td> <td> dabigatran etexilate 150 mg q.d. for 12-15 days<br>  <i>versus</i> <br> Enoxaparin 40 mg q.d. for 12-15 days </td> <td> Total knee replacement </td> <td> follow-up 12-15 days, median 14d<br> n=877/876<br> Parallel groups<br> double blind <br> US, Canada, Mexico, UK </td> </tr> <tr> <td> <a href="index.html"> BISTRO II (225mg bid), 2005 </a> <br> </td> <td> dabigatran etexilate 225 mg twice daily for 6�10 days<br>  <i>versus</i> <br> subcutaneous enoxaparin 40 mg once daily </td> <td> patients undergoing total hip or knee replacement </td> <td> follow-up <br> n=393/392<br> Parallel groups<br> double blind <br> Europe and South Africa (2 centres) </td> </tr> <tr> <td> <a href="index.html"> ODIXa-KNEE, 2005 </a> <br> </td> <td> BAY 59-7939 5mg b.i.d. for 5�9 days<br>  <i>versus</i> <br> enoxaparin 30 mg b.i.d. for 5�9 days </td> <td> patients undergoing elective total knee replacement </td> <td> follow-up 5-9 days<br> n=102/105<br> Parallel groups<br> double blind <br> North America </td> </tr> <tr> <td> <a href="index.html"> RECORD 3, 2008 </a> <br> NCT00361894 </td> <td> rivaroxaban 10 mg once daily for 10- 14 days<br>  <i>versus</i> <br> enoxaparin 40 mg subcutaneous once daily </td> <td> patients undergoing total knee arthroplasty </td> <td> follow-up 13-17 days<br> n=1254/1277<br> Parallel groups<br> double blind <br> 19 countries worldwide </td> </tr> <tr> <td> <a href="index.html"> RECORD 4, 2009 </a> <br> NCT00362232 </td> <td> rivaroxaban 10mg once daily for 10 to 14 days<br>  <i>versus</i> <br> enoxaparin 30 mg twice daily by subcutaneous injection for 10 to 14 days </td> <td> patients who had undergone total-knee-replacement surgery </td> <td> follow-up 40 days<br> n=1584/1564<br> Parallel groups<br> double blind <br> 12 countries </td> </tr> <tr> <td> <a href="index.html"> ADVANCE-1, 2008 </a> <br> NCT00371683 </td> <td> apixaban 2.5 mg orally twice daily for 10 to 14 days<br>  <i>versus</i> <br> enoxaparin 30mg subcutaneously every 12 hours </td> <td> patients undergoing knee-replacement surgery </td> <td> follow-up 10-14 days<br> n=1599/1596<br> Parallel groups<br> double blind <br> 14 countries </td> </tr> <tr> <td> <a href="index.html"> ADVANCE 2 (CV185-047), 2010 </a> <br> NCT00452530 </td> <td> apixaban 2.5mg twice daily during 12 days<br>  <i>versus</i> <br> enoxaparin 40mg once daily 12 days </td> <td> patients undergoing elective unilateral or bilateral total knee replacement </td> <td> follow-up 12 days<br> n=1528/1529<br> Parallel groups<br> double blind <br> 27 countries </td> </tr> <tr> <td> <a href="index.html"> CV185-010, 2007 </a> <br> NCT00097357 </td> <td> apixaban 2.5mg BID, 5mg BID, 10mg BID, 5mgQD, 20mg QD for 12 days<br>  <i>versus</i> <br> enoxaparin 30mg twice daily for 12 days </td> <td> patients undergoing elective total knee replacement surgery </td> <td> follow-up 12 days<br> n=-9/-9<br> Parallel groups<br> double blind <br> </td> </tr> </table> <h2>References</h2> <p> <b>RE-MOBILIZE (220mg), 2008 : </b> The Oral Thrombin Inhibitor Dabigatran Etexilate vs the North American Enoxaparin Regimen for the Prevention of Venous Thromboembolism after Knee Arthroplasty Surgery. <i>J Arthroplasty 2008;:</i> [PMID 18534438] </p> <p> <b>RE-MODEL (220mg), 2007 : </b> Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, K�lebo P, Christiansen AV, Hantel S, Hettiarachchi R, Schnee J, B�ller HROral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. <i>J Thromb Haemost 2007 Nov;5:2178-85</i> [PMID 17764540] </p> <p> <b>RE-MODEL (150mg), 2007 : </b> Eriksson BI, Dahl OE, Rosencher N, Kurth AA, van Dijk CN, Frostick SP, K�lebo P, Christiansen AV, Hantel S, Hettiarachchi R, Schnee J, B�ller HROral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. <i>J Thromb Haemost 2007;5:2178-85</i> [PMID 17764540] 10.1111/j.1538-7836.2007.02748.x </p> <p> <b>RE-MOBILIZE (150mg), 2008 : </b> Ginsberg JS, Davidson BL, Comp PC, Francis CW, Friedman RJ, Huo MH, Lieberman JR, Muntz JE, Raskob GE, Clements ML, Hantel S, Schnee JM, Caprini JAOral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. <i>J Arthroplasty 2009;24:1-9</i> [PMID 18534438] 10.1016/j.arth.2008.01.132 </p> <p> <b>BISTRO II (225mg bid), 2005 : </b> Eriksson BI, Dahl OE, B�ller HR, Hettiarachchi R, Rosencher N, Bravo ML, Ahnfelt L, Piovella F, Stangier J, K�lebo P, Reilly PA new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial. <i>J Thromb Haemost 2005 Jan;3:103-11</i> [PMID 15634273] </p> <p> <b>ODIXa-KNEE, 2005 : </b> Turpie AG, Fisher WD, Bauer KA, Kwong LM, Irwin MW, K�lebo P, Misselwitz F, Gent MBAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study. <i>J Thromb Haemost 2005 Nov;3:2479-86</i> [PMID 16241946] </p> <p> <b>CV185-010, 2007 : </b> Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman DThe efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. <i>J Thromb Haemost 2007 Dec;5:2368-75</i> [PMID 17868430] </p> <p> <b>RECORD 3, 2008 : </b> Lassen MR, Ageno W, Borris LC, Lieberman JR, Rosencher N, Bandel TJ, Misselwitz F, Turpie AGRivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. <i>N Engl J Med 2008 Jun 26;358:2776-86</i> [PMID 18579812] </p> <p> <b>RECORD 4, 2009 : </b> Turpie AG, Lassen MR, Davidson BL, Bauer KA, Gent M, Kwong LM, Cushner FD, Lotke PA, Berkowitz SD, Bandel TJ, Benson A, Misselwitz F, Fisher WDRivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. <i>Lancet 2009;:</i> [PMID 19411100] </p> <p> <b>ADVANCE-1, 2008 : </b> Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Portman RJApixaban or enoxaparin for thromboprophylaxis after knee replacement. <i>N Engl J Med 2009;361:594-604</i> [PMID 19657123] </p> <p> <b>CV185-034, : </b> Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Portman RJApixaban or enoxaparin for thromboprophylaxis after knee replacement. <i>N Engl J Med 2009;361:594-604</i> [PMID 19657123] </p> <p> <b>ADVANCE 2 (CV185-047), 2010 : </b> Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Hornick PApixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. <i>Lancet 2010 Mar 6;375:807-15</i> [PMID 20206776] 10.1016/S0140-6736(09)62125-5 </p>