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antithrombotics in thrombosis prevention for elective hip replacement, clinical trials results

apixaban versus enoxaparin
ADVANCE 3, 2010 NCT00423319	apixaban 2.5mg twice daily for 35 days versus enoxaparin 40mg once daily for 35 days	patients undergoing elective total hip replacement surgery	double blind Follow-up duration: 35 days (+60) 21 countries
Aspirin versus no treatment
Rocha, 1986	Aspirin 250mg or 1000mg daily versus control (combination of heparin plus dihydroergotamine)	total hip replacement	open Follow-up duration: 1 weeks
Aspirin versus placebo
Stockholm-I, 1975	Aspirin 2000mg daily versus placebo	elective surgery of the hip	double blind Follow-up duration: 2 weeks
Harris-I, 1977	Aspirin 1200mg daily versus placebo	patients over 40 years of age, who had undergone total hip replacement	double-blind Follow-up duration: 1 weeks
Sautter, 1983	Aspirin 900mg daily + sulfinpyrazone versus placebo	patient with total hip replacement	Follow-up duration: 3 weeks
certoparine + DHE versus Unfractionated heparin
Haas , 1987	Sandoz +0.5mg DHE versus Unfractionated heparin	Elective hip
Lassen, 1988	certoparin 3000+0.5mg DHE, x1 versus Placebo	Elective hip	double blind Follow-up duration: 6 days
dabigatran 150mg versus enoxaparin
RE-NOVATE (150mg), 2007 NCT00168818	dabigatran etexilate 150 mg q.d. 28-35 days versus Enoxaparin 40 mg q.d. for 28-25 days	Total hip replacement	double blind Follow-up duration: 28-35 days, median 33d Europe, Australia, South Africa
dabigatran 220mg versus enoxaparin
RE-NOVATE 2, 0 NCT00657150	dabigatran 220mg once daily for 28-35 Days versus enoxaparin 40mg subcutaneous once daily for 28-35 Days	patients undergoing total hip-replacement surgery	double-blind Follow-up duration: 28-35 days (mean 32d)
RE-NOVATE (220mg), 2007 NCT00168818	dabigatran etexilate 220 mg q.d. for 28-35 days versus Enoxaparin 40 mg q.d. for 23-35 days	Total hip replacement	double blind Follow-up duration: 28-35 days, median 33d Europe, Australia, South Africa
dalteparin versus Dextran
Matzsch , 1991	dalteparin versus Dextran	Elective hip
Eriksson , 1988	dalteparin versus Dextran	Elective hip
Matzsch , 1988	dalteparin versus Dextran	Elective hip
dalteparin versus placebo
Torholm, 1991	dalteparin 5000x1 versus Placebo	Elective hip	double blind Follow-up duration: 9 days
dalteparin versus Unfractionated heparin
Binsack , 1986	dalteparin versus Unfractionated heparin	Elective hip
Barre , 1987	dalteparin versus Unfractionated heparin	Elective hip
Dechavanne , 1989	dalteparin versus Unfractionated heparin	Elective hip
Eriksson , 1989	dalteparin versus Unfractionated heparin	Elective hip
Haas , 1985	dalteparin versus Unfractionated heparin	Elective hip
desirudin versus enoxaparin
Ericksson, 1997	desirudin 15mg SC twice daily for 8-12 days versus enoxaparin 40mg once daily for 8-12 days	Patients who undergo total hip replacement	double blind Europe
desirudin versus UFH
REVASC, 1997	desirudin 15mg twice daily versus unfractionated heparin 5000 IU three times a day	patients having a primary elective total hip replacement
Eriksson, 1996	recombinant hirudin, desirudin (CGP 39393) 10, 15, or 20 mg twice daily started just before surgery and continued for 8-11 days versus unfractionated heparin 5000 IU three times daily started just before surgery and continued for 8-11 days	patients undergoing elective hip surgery	double blind Europe
edoxaban versus enoxaparin (short duration)
STARS J-V, 0 NCT01181167	edoxaban 30 mg once daily for 11 to 14 days versus subcutaneous enoxaparin 2,000 IU, equivalent to 20 mg, twice daily (BID) for 11 to 14 days	total hip arthroplasty	double-blind japan
enoxaparin versus Dextran
DES Group , 1991	Enoxaparin versus Dextran	Elective hip
enoxaparin versus no treatment
Warwick, 1995	enoxaparin 4000x1 + elastic stockings versus no treatment + elastic stockings	Elective hip	open Follow-up duration: 8-10 days
enoxaparin versus placebo
Kalodiki, 1996	enoxaparin 4000x1 versus Placebo	Elective hip	double blind Follow-up duration: discharge (8-12 days )
Samama, 1997	enoxaparin 4000x1+elastic stockings versus Placebo+elastic stockings	Elective hip	double blind Follow-up duration: 8-12 days
Turpie, 1986	Enoxaparin 3000 x2 versus Placebo	Elective hip	double blind Follow-up duration: 14 days or discharge
enoxaparin versus Unfractionated heparin
Levine , 1991	Enoxaparin versus Unfractionated heparin	Elective hip
Planes , 1988	Enoxaparin versus Unfractionated heparin	Elective hip
fluxum versus Unfractionated heparin
Chiapuzzo , 1988	Fluxum versus Unfractionated heparin	Elective hip
Pini , 1989	Fluxum versus Unfractionated heparin	Hip
fondaparinux versus enoxaparin
EPHESUS (Lassen), 2002	fondaparinux 2.5-mg once-daily subcutaneous, starting 6 hours after surgery versus enoxaprin 40mg once daily	elective hip replacement surgery	double blind Follow-up duration: 11 days (6 weeks) 16 European countries
PENTATHLON (Turpie), 2002	fondaparinux 2.5-mg once-daily subcutaneous, starting 6 hours after surgery versus enoxaparin 30mg twice daily (North america recommendation)	elective hip replacement surgery	double blind Follow-up duration: 11 days USA, Canada, Australia
Hydroxychloroquine versus placebo
Cooke, 1977	Hydroxychloroquine versus placebo	elective surgery on the hip	double-blind Follow-up duration: 2 weeks
Hume-A, 1977	Hydroxychloroquine versus placebo	total hip replacement	Follow-up duration: 2 weeks
Stockholm-II, 1981	Hydroxychloroquine versus placebo	total hip replacement	Follow-up duration: 2 weeks
nadroparin versus no treatment
Yoo, 1997	nadroparin 41/kgx1 days 1-3, 62/kg x1 days 4-11+elastic stockings versus no treatment	Elective hip	open Follow-up duration: 10 days
nadroparin versus Unfractionated heparin
Leyvraz, 1991	Fraxiparin versus Unfractionated heparin	Elective hip
rivaroxaban versus enoxaparin
RECORD 1, 2008 NCT00329628	rivaroxaban 10mg once daily for 35 days versus enoxaparin 40mg subcutaneous once daily for 31-39 days	patients undergoing total hip arthroplasty	double blind Follow-up duration: 36 days (range 30-42) 27 countries worldwide
rivaroxaban versus enoxaparin (short duration)
ODIXa-HIP 10mg, 2006	rivaroxaban 10mg daily for 5–9 days versus once-daily subcutaneous enoxaparin dose of 40 mg for 5–9 days	patients undergoing elective total hip replacement	double blind Follow-up duration: 5-9 days Europe, Israel
rivaroxaban (long duration) versus enoxaparin (short duration)
RECORD 2, 2008 NCT00332020	extended thromboprophylaxis with rivaroxaban 10mg once daily for 31-39 days versus enoxaparin 40mg subcutaneous once daily for 10-14 days	patients undergoing elective total hip replacement	double blind Follow-up duration: 30-42 days 21 countries worldwide
semuloparin versus enoxaparin
SAVE-HIP1, 2012 NCT00697099	Semuloparin 20 mg once-daily versus Enoxaparin 40 mg once-daily
SR123781A versus enoxaparin
DRIVE, 2008 NCT00338897	SR123781A for 5-10 days, doses ranging from 0.25 to 4.0 mg daily for 10 days versus enoxaparin 40 mg	patients undergoing total hip replacement surgery	double blind Follow-up duration: 5-10 days 12 countries
tinzaparin versus placebo
Lassen, 1991	tinzaparin 50/kg x1 +elastic stockings versus Placebo+elastic stockings	Elective hip	double blind Follow-up duration: 8-10 days
ximelagatran versus Enoxaparin
Platinum (Colwell), 2003	Ximelagatran 24 mg orally b.d., starting at least 12 h after surgery for 7–12 days versus Enoxaparin 30 mg s.c. b.d.,starting at least 12 h after surgery for 7–12 days	adults undergoing hip replacement	double-blind Follow-up duration: 7–12 days USA, Canada, Israel, Mexico,Argentina, South Africa
METHRO III, 2002	Melagatran 3 mg s.c. 4–12h after surgery, then ximelagatran24 mg orally b.d. for 7–10 days versus Enoxaparin 40 mg s.c. o.d. 12 h before surgery for 7–10 days	hip or knee replacement	double-blind Follow-up duration: 8–11 days Europe, South Africa
EXPRESS, 2003	Melagatran 2 mg s.c. up to 30 min before surgery, then melagatran 3 mg at least 8 hafter surgery, then ximelagatran 24 mg orally b.d. for 8–11 days versus Enoxaparin 40 mg s.c. o.d.,starting 12 h before surgery for 8–11 days	hip or knee replacement	double-blind Follow-up duration: 8–11 days Europe

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