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antithrombotics in thrombosis prevention for hip Fracture, clinical trials results

aspirin versus placebo
PEP hip-fracture, 2000
aspirin 160mg/d started preoperatively and continued for 35 days
versus
placebo
patients undergoing surgery for hip fractureDouble blind
Follow-up duration: 35 days
Australia, New Zealand, South Africa,
certoparine + DHE versus Unfractionated heparin
Lassen, 1989
certoparin 3000+0.5mg DHE x1
versus
placebo
Hip fracturedouble blind
Follow-up duration: 6 days
dalteparin versus placebo
Jorgensen, 1989
dalteparin 5000 x1
versus
Placebo
Hip fracturedouble blind
Follow-up duration: 9 days
extended prophylaxis versus standard prophylaxis
PENTHIFRA–PLUS (Eriksson), 2003
25-31 days of fondaparinux 2.5-mg once-daily
versus
6-8 days of fondaparinux 2.5-mg once-daily
patients undergoing hip fracture surgerydouble blind
Follow-up duration: 19-23 days
fondaparinux versus enoxaparin
PENTHIFRA (Eriksson), 2001
fondaparinux 2.5-mg once-daily subcutaneous, starting 6 hours after surgery
versus
enoxaprin 40mg once daily
hip fracture surgerydouble blind
Follow-up duration: 11 days
21 countries
nadroparin versus placebo
Sourmelis, 1995
nadroparin 3075x1 preop, 6150x1 post op
versus
Placebo
Hip fracturedouble blind
Follow-up duration: 10-12 days
semuloparin versus enoxaparin
SAVE-HIP 2, 2012
NCT00721760
Semuloparin 20 mg once-daily
versus
Enoxaparin 40 mg once-daily
hip fracture surgery

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