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antithrombotics in thrombosis prevention for general surgery, clinical trials results

antixarin versus unfractionated heparin
Limmer, 1994	Antixarin 2500 anti Xa units versus UFH 15 000 units	General surgery	Open
ardeparin versus unfractionated heparin
Godwin, 1993	Ardeparin 90 and 50 units/kg b.i.d versus UFH 10 000 units	Abdominopelvic surgery	Blind
aspirin versus control
Clagett, 1975	A1300 versus control		open
Zekert VI, 1982	A1500 versus control		open
aspirin versus placebo
MRC, 1972	A600 versus placebo	general surgery	double-blind
Loew DVT, 1974	A600 versus Placebo		double-blind
Erfurt-A, 1979	A1500 versus Placebo		double-blind
Zekert V, 1980	A1500+Hep??? versus Placebo		double-blind
Vinazzer I, 1980	A1500+Hep v Hep versus Placebo		double-blind
Vinazzer II, 1977	A1000+Hepv Hep versus Placebo		double-blind
PEP hip-fracture, 2000	aspirin 160mg/d started preoperatively and continued for 35 days versus placebo	patients undergoing surgery for hip fracture	Double blind Follow-up duration: 35 days Australia, New Zealand, South Africa,
PEP elective arthroplasty, 2000	aspirin 160mg/d started preoperatively and continued for 35 daysA versus placebo	Patients undergoing elective hip or knee arthroplasty	Double blind Follow-up duration: 35 days New Zealand
certoparin versus unfractionated heparin
Schmitz-Huebner, 1984	Certoparin (dose 1 and dose 2) b.i.d. versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 1 month
Sasahara, 1986	Certoparin 3000 + DHE versus UFH 10 000 units +DHE	Abdominal surgery	Blind Follow-up duration: 7 days
Voigt, 1986	Certoparin 3000 + DHE versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 10 days
Welzel, 1988	Certoparin 2500 + DHE versus UFH 10 000 units+DHE	Abdominal surgery	Open Follow-up duration: 7 days
Kakkar, 1989	Certoparin 3000 + DHE versus UFH 10 000 units+DHE	Abdominal surgery	Blind
Adolf, 1989	Certoparin 3000 versus UFH 15 000 units	Abdominal surgery	Blind Follow-up duration: 1 month
Heilmann, 1989	Certoparin 3000 versus UFH 15 000 units	Gynaecological surgery	Blind Follow-up duration: 10 days
Baumgartner, 1989	Certoparin 3000 + DHE versus UFH 5 000 units+DHE	Abdominal surgery	Blind Follow-up duration: 10 days
Hoffmann and Largiade, 1990	Certoparin 3000 + DHE versus UFH 10 000 units	Abdominal surgery	NA
Koppenhagen, 1990	Certoparin 3000 anti Xa units versus UFH 15 000 units	Abdominal surgery	Blind
Schielke, 1991	Certoparin 3000 anti Xa units + DHE versus UFH 10 000 units + DHE	Abdominal surgery	Open
Koppenhagen, 1992	Certoparin 3000 anti Xa units versus UFH 15 000 units	Abdominal surgery	Blind
Hoffmann and Largiader, 1992	Certoparin 3000 anti Xa units versus UFH 10 000 units	Abdominothoracic surgery	Blind
Heilmann, 1997	Certoparin 3000 anti Xa units versus UFH 15 000 units	Gynaecological and breast surgery	Blind
Haas, 1999	Certoparin 3000 anti Xa units versus UFH 15 000 units	General surgery	Blind
dalteparin versus placebo
Ockelford , 1989	Dalteparin 2500 anti-Xa units versus Placebo	general surgery	Blind
dalteparin versus unfractionated heparin
Briel, 1988	Dalteparin 5000 versus UFH 10 000 units+DHE	Gynaecological surgery	NA
Bergqvist, 1986	Dalteparin 5000 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 1 month
Onarheim, 1986	Dalteparin 5000 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 1 month
Koller, 1986	Dalteparin 7500 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 30 days
Koller, 1986	Dalteparin 2500 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 30 days
Fricker, 1988	Dalteparin 5000 versus UFH 15 000 units	Abdominopelvic surgery	Open Follow-up duration: 1-2 months
Bergqvist, 1988	Dalteparin 5000 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 1 month
Caen, 1988	Dalteparin 2500 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: 1 month
Borstad, 1988	Dalteparin 5000 versus UFH 10 000 units	Gynaecological surgery	Blind
Creperio, 1990	Dalteparin 2500 versus UFH 10 000 units	General surgery	Blind
Hartl, 1990	Dalteparin 2500 versus UFH 10 000 units	Abdominal surgery	Blind Follow-up duration: > 7 days
Borstad, 1992	Dalteparin 2500 anti Xa units versus UFH 10 000 units	Gynaecological surgery	Blind
Kakkar, 1993	Dalteparin 2500 anti Xa units versus UFH 10 000 units	Abdominal surgery	Blind
dipyridamol + aspirin versus control
Parodi I, 1973	Dip,A1000+Dip versus control		open
Parodi II, 1973	A1500,Dip,A+Dip versus control		open
Australian I, 1975	A1000+Dip versus control		open
Australian II, 1976	A1000+Dip versus control		open
Toulouse I, 1979	A990+Dip versus control		open
Zekert-III, 1977	A1500,A1300+Dip,A1000+Dip versus control		open
Harjola DVT, 1982	A1500,Dip,A+Dip versus control		open
Weiss, 1977	A990+Dip versus control		open
dipyridamol + aspirin versus placebo
Encke IA, 1976	A990,A+Dip versus Placebo		double-blind
Encke IB, 1976	A1500,A990+Dip versus Placebo		double-blind
enoxaparin versus no treatment
Ho [43],	Enoxaparin 4000 anti-Xa units versus No treatment		Open
enoxaparin versus unfractionated heparin
Samama 2, 1988	Enoxaparin 4000 versus UFH 15 000 units	General surgery	Open Follow-up duration: 7 days
Samama 1, 1988	Enoxaparin 2000 versus UFH 15 000 units	General surgery	Open Follow-up duration: 7 days
Samama 3, 1988	Enoxaparin 6000 versus UFH 15 000 units	General surgery	Open Follow-up duration: 7 days
Kaaja, 1992	Enoxaparin 2000 anti Xa units versus UFH 10 000 units	Gynaecological surgery	Blind
Gazzaniga (ISG), 1993	Enoxaparin 2000 anti Xa units versus UFH 10 000 units	General and vascular surgery	Open
Nurmohamed, 1995	Enoxaparin 2000 anti Xa units versus UFH 15 000 units	General surgery	Blind
McLeod (Canadian), 1995	Enoxaparin 4000 anti Xa units versus UFH 15 000 units	Colorectal surgery	Blind
Gonzalez, 1996	Bemiparin 2500 anti Xa units versus UFH 10 000 units	Abdominal surgery	Blind
ENOXACAN, 1997	Enoxaparin 4000 anti Xa units versus UFH 15 000 units	Abdominopelvic surgery	Blind
fluxum versus placebo
Valle , 1988	Parnaparin 3200 anti-Xa units versus Placebo	general surgery	Blind
hydroxychloroquine versus placebo
Carter IA, 1971	Hydroxy versus placebo		double-blind
Carter IB, 1971	Hydroxy versus placebo		double-blind
Carter II, 1974	Hydroxy versus Placebo		double-blind
New York, 1977	Hydroxy versus placebo		double-blind
Vermont, 1975	Hydroxy versus placebo		double-blind
nadroparin versus no treatment
Marassi [41],	Nadroparin 2850 anti-Xa units versus No treatment		Open
nadroparin versus placebo
Balas [40],	Nadroparin 2850 anti-Xa units versus Placebo		Blind
Pezzuoli, 1989	Nadroparin 2850 anti-Xa units versus Placebo	general surgery	Blind
nadroparin versus unfractionated heparin
Kakkar and Murray, 1985	Nadroparin 2850 versus UFH 10 000 units	General surgery	Blind Follow-up duration: 10 days
EFS, 1988	Nadroparin 2850 versus UFH 15 000 units	Abdominal surgery	Open Follow-up duration: 1 month
Dahan, 1989	Nadroparin 2850 versus UFH 15 000 units	Thoracic surgery	Open
Barbui, 1990	Nadroparin 2850 anti Xa units versus UFH 10 000 units	General surgery	Open
Eurin, 1994	Nadroparin 2850 anti Xa units versus UFH 15 000 units	Abdominopelvic surgery	Open
parnaparin versus unfractionated heparin
Catania, 1988	Parnaparin 3200 versus UFH 15 000 units	Abdominal surgery	Open
Salcuni, 1988	Parnaparin 3200 versus UFH 15 000 units	Abdominal surgery	Open
Verardi, 1989	Parnaparin 6400 versus UFH 10 000 units	Abdominal/urological surgery	NA
Garcea, 1992	Parnaparin 3200 anti Xa units versus UFH 15 000 units	Abdominal surgery	Open
reviparin versus unfractionated heparin
Kakkar, 1993	Reviparin 1750 anti Xa units versus UFH 10 000 units	General and gynaecological surgery	Blind
sp versus control
Veth, 1985	Sp+Hep v Hep versus control		open
sp versus placebo
Athens, 1981	Sp versus placebo		double-blind
SSHA versus unfractionated heparin
ToÈrngren, 1984	SSHA 50 mg and 37.5 mg versus UFH 10 000 units	General surgery	Blind Follow-up duration: Discharge
Suloctidil versus placebo
Turpie, 1985	Suloctidil versus Placebo		double-blind
ticlopidine versus placebo
Lasierra, 1982	Ticlopidine versus placebo		double-blind
Walker, 1974	ticlopidine versus placebo		double-blind
tinzaparin versus placebo
Bergqvist [42],	Tinzaparin 3500 anti-Xa units versus Placebo		Blind
tinzaparin versus unfractionated heparin
Leizorovicz, 1991	Tinzaparin 2500 and 3500 anti Xa units versus UFH 10 000 units	Abdominothoracic and gynaecological surgery	Blind
UFH versus aspirin
Loew, 1977	UFH twice daily for 7 days versus aspirin	all other general surgery
Vinazzer, 1980	UFH twice daily for A days versus aspirin	all other general surgery
UFH versus DHE
Muiticentre, 1984	UFH twice daily for 5-7 days versus DHE	all other general surgery
Muiticentre 53,S4, 1984	UFH twice daily for 5-7 days versus DHE	all other general surgery
UFH versus no treatment
Abernethy, 1974	UFH twice daily for 7 days versus no treatment	all other general surgery
Abraham-Inpijn, 1979	UFH twice daily for 7 days versus no treatment	all other general surgery
Bergqvist, 1980	UFH twice daily for 5 days versus no treatment	all other general surgery
Caloghera, 1984	UFH 3 times daily for 7 days versus no treatment	all other general surgery
Clarke-Pearson, 1983	UFH twice daily for 7 days versus no treatment	all other general surgery
Gallus, 1973	UFH 3 times daily for A versus no treatment	all other general surgery
Gallus, 1976	UFH 3 times daily for 7 days versus no treatment	all other general surgery
Gordon-Smith, 1972	UFH twice daily for 5 days versus no treatment	all other general surgery
Groote Schuur, 1979	UFH 3 times daily for 6 days versus no treatment	all other general surgery
Gruber, 0	UFH 3 times daily for 7 days versus no treatment	All other general surgery
Kakkar (IMT), 0	UFH 3 times daily for 7 days versus no treatment	All other general surgery
Kettunen, 1974	UFH 3 times daily for 7 days versus no treatment	all other general surgery
Koppenhagen, 1982	UFH twice daily versus no treatment	all other general surgery
Kraytman, 1976	UFH 3 times daily for 6 days versus no treatment	all other general surgery
Kraytman, 1977	UFH 3 times daily for 6 days versus no treatment	all other general surgery
Marchelli, 1983	UFH 3 times daily for ? versus no treatment	all other general surgery
Multiunit, 1974	UFH twice daily for 7 days versus no treatment	all other general surgery
Nicolaides, 1972	UFH twice daily for 7 days versus no treatment	all other general surgery
Plante, 1979	UFH twice daily for 8 days versus no treatment	all other general surgery
Sagar, 1974	UFH twice daily for 5 days versus no treatment	all other general surgery
Spebar, 1981	UFH twice daily for 5-7 days versus no treatment	all other general surgery
Ziemski, 1979	UFH 3 times daily for 2 days versus no treatment	all other general surgery
UFH versus oral anticoagulant
van Geloven, 1977	UFH twice daily for 4 days versus Oral anticoagulant	all other general surgery
UFH versus placebo
Belch, 1980	UFH twice daily for 7 days versus placebo	all other general surgery
Covey, 1975	UFH twice daily for 8 days versus placebo	all other general surgery
Jourdan, 1984	UFH twice daily for 5 days versus placebo	all other general surgery
Kakkar, 1972	UFH twice daily for 7 days versus placebo	All other general surgery
Kiil, 1978	UFH twice daily for 7 days versus placebo	All other general surgery
Kraytman, 1977	UFH 3 times daily for 6 days versus placebo	all other general surgery
Kruse-Blinkenberg, 1980	UFH 3 times daily for 8 days versus placebo	all other general surgery
Lahnborg, 1975	UFH twice daily for 5 days versus placebo	all other general surgery
Lahnborg, 1976	UFH twice daily for 5 days versus placebo	all other general surgery
Lawrence, 1977	UFH twice daily for 5 days versus placebo	all other general surgery
Marchetti, 1982	UFH 3 times daily versus placebo	all other general surgery
Muiticentre, 1984	UFH twice daily for 5-7 days versus placebo	all other general surgery
Ribaudo, 1975	UFH twice daily for A days versus placebo	all other general surgery
Roberts, 1975	UFH twice daily for 7 days versus placebo	all other general surgery
Strand, 1975	UFH twice daily for 7 days versus placebo	all other general surgery
Taberner, 1978	UFH twice daily for 7 days versus placebo	all other general surgery
Torngren, 0	UFH twice daily for 6-8 days versus placebo	all other general surgery
Torngren, 1978	UFH 3 times daily for 6-8 days versus placebo	all other general surgery
Torngren, 1978	UFH twice daily for 6-8 days versus placebo	all other general surgery
Wu, 1977	UFH twice daily for 7 days versus placebo	all other general surgery

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