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antithrombotics in thrombosis prevention for neurosurgery, clinical trials results

enoxaparin versus placebo
Agnelli, 1998
Enoxaparin, 40 mg/d subcutaneously within 24 hours postoperatively plus compression stockings for >=7 days
versus
compression stockings + placebo
Elective neurosurgery, 18 years or older, without excess bleeding risk
Follow-up duration: 30 days
Melon, 1987
Enoxaparin, 20 mg/d subcutaneously 18-24 hours postoperatively for 10 days
versus
placebo
Neurosurgery, adult, 45-90 kg of weight, without excess bleeding risk
Follow-up duration: NA
nadroparin versus placebo
Nurmohamed, 1996
Nadroparin, 7500 Institute Choay anti-Xa units per day subcutaneously 18-24 hours postoperatively plus compression for 10 days
versus
compression stockings + placebo
Craniotomy or spinal surgery for tumor or injury, 18 years or older, without excess bleeding risk
Follow-up duration: 56 days
UFH versus no treatment
Cerrato, 1978
Unfractionated heparin, 5000 IU subcutaneously 3 times a day, starting 2 hours preoperatively for +7 days
versus
no treatment
Elective neurosurgery for tumors, 40 years or older
Follow-up duration: NA

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