cardiac arrest clinical trials results

active compression-decompression CPR versus standard CPR
Aufderheide, 2011	active compression-decompression cardiopulmonary resuscitation versus standard cardiopulmonary resuscitation	adults (presumed age or age >=18 years) who had a nontraumatic arrest of presumed cardiac cause	open Follow-up duration: hospital discharge USA
amiodarone versus lidocaine
ALIVE, 2002	intravenous amiodarone plus lidocaine placebo versus intravenous lidocaine plus amiodarone placebo	out-of-hospital ventricular fibrillation resistant to three shocks, intravenous epinephrine, and a further shock; or recurrent ventricular fibrillation after initially successful defibrillation	double blind Follow-up duration: 1 day
amiodarone versus placebo
ARREST, 1999	intravenous amiodarone 300mg versus placebo	Patients with cardiac arrest by ventricular fibrillation (or pulseless ventricular tachycardia) and not resuscitated after receiving three or more precordial shocks	double blind
Automatic External Defibrillation versus Cardiopulmonary Resuscitation
HAT, NCT00047411	Automatic External Defibrillation versus Cardiopulmonary Resuscitation	people who have had an anterior myocardial infarction	open
PAD (Hallstrom), 2004	lay volunteers trained in cardiopulmonary resuscitation and the use of automated external defibrillators versus lay volunteers trained in cardiopulmonary resuscitation alone		open US, Canada
compression-only CPR versus standard CPR
Rea, 2010 NCT00219687	dispatcher instructions to bystanders for performing CPR with chest compression alone versus dispatcher instructions to bystanders for performing CPR with chest compression plus rescue breathing	persons 18 years of age or older with out-of-hospital cardiac arrest	open
Svensson, 2010 CT20080012	compression-only CPR versus standard CPR	Patients with suspected, witnessed, out-of-hospital cardiac arrest	open
Hallstrom, 2000	CPR by chest compression alone versus CPR by chest compression plus mouth-to-mouth ventilation		open
Hallstrom + preliminary study,	versus
compressions first versus defibrillation first
Jost, 2010	chest compressions before defibrillation versus immediate defibrillation before chest compressions		France
Baker, 2008	chest compressions before defibrillation versus immediate defibrillation before chest compressions		Australia
Jacobs, 2005	chest compressions before defibrillation versus immediate defibrillation before chest compressions		Australia
Wik, 2003	chest compressions before defibrillation versus immediate defibrillation before chest compressions		Norway
fish oil versus placebo
Raitt , 2006 NCT00004558	Fish oil 1.3g versus placebo (olive oil)		double blind
SOFA , 2006 NCT00110838	Fish oil 0.9g versus placebo (High-oleic sunflower oil)		double blind Follow-up duration: 356 days (14-379) Europe
Leaf, 2005	Fish oil 2.6g versus placebo (olive oil)
t-PA versus placebo
Abu-Laban, 2002	t-PA 100mg over a 15-minute period versus placebo	Victims of cardiac arrest with pulseless electrical activity for more than one minute and had had no palpable pulse for more than three minutes during resuscitative efforts and at the time of the initiation of the study drug	double blind Canda
tenecteplase versus placebo
TROICA, 2008 NCT00157261	tenecteplase (dose according to estimated body weight) versus placebo	adults with witnessed out-of-hospital cardiac arrest of presumed cardiac origin and with initiation of basic or advanced life support within 10 minutes after collapse	doubel blind Follow-up duration: 30 days Europe
TICA, 2004	tenecteplase 50 mg versus placebo	All victims of out of hospital cardiac arrest	double blind Australia
vasopressin versus epinephrine
Lindner, 1997	Vasopressin 40 U IV versus epinephrine 1 mg intravenously	patients in ventricular fibrillation resistant to electrical defibrillation	double blind Germany
Li, 1999	Vasopressin, 0.5 U/kg (low dose) or 1.0 U/kg (high dose) versus epinephrine		China
Lee, 2000	Vasopressin, 40 U (unknown route) versus epinephrine		na
Stiell, 2001	Vasopressin, 40 U IV versus epinephrine 1 mg intravenously	adults who had cardiac arrest and required drug therapy	double blind Canada
Wenzel, 2004	Vasopressin, 40 U IV versus epinephrine 1mg IV	adults who had had an out-of-hospital cardiac arrest	open Austria, Germany, Switzerland