A randomised clinical trial investigating the effect of half-dose t-PA versus no fibrinolysis in patients presenting with moderate PE
Studied treatment |
half-dose thrombolysis half-dose thrombolysis (for those >50 kg, 10 mg in one minute followed by 40 mg in two hours; for those <50 kg, 0.5 mg/kg total dose: 10 mg in one minute followed by the remainder in two hours) and concomitant anticoagulation with around a 20% to 30% reduced dose of enoxaparin or heparin |
Control treatment | standard regimen of anticoagulants alone |
Patients | patients presenting with moderate PE |
Group sizes | -9 / -9 |
Blindness | open | Inclusion period | |
Follow-up duration | 28 months | Centers | single center |
Lost to FU | geographical localisation | ||
Primary endpoint | Pulmonary hypertension | Design | Parallel groups |
Systolic blood pressure | |||
Diastolic blood pressure | |||
delay from onset | |||
diagnostic test |
Links
Appears in following systematic reviews: