A randomised clinical trial investigating the effect of Multiple risk factor interventions versus control in high-risk men aged 35 to 57 years
Studied treatment | special intervention (SI) program consisting of stepped-care treatment for hypertension, counseling for cigarette smoking, and dietary advice for lowering blood cholesterol levels |
Control treatment | no intervention |
Age (yr) | 46 y |
Age range (yr) | 35-47 |
interventions | Diet, smoking, weight, antihypertensive drugs |
Patients | high-risk men aged 35 to 57 years |
Group sizes | 6428 / 6438 |
Blindness | open | Inclusion period | |
Follow-up duration | 6 yr | Centers | |
Lost to FU | geographical localisation | ||
Primary endpoint | Design | Parallel groups |
Randomisation of individuals
Mortality rates after 10.5 years for participants in the Multiple Risk Factor Intervention Trial. Findings related to a priori hypotheses of the trial. The Multiple Risk Factor Intervention Trial Research Group. JAMA 1990;263:1795-801 [PMID: 2179590] link to pdf add to Mendeley
Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA 1982;248:1465-77 [PMID: 7050440] link to pdf add to Mendeley
ClinicalTrial.gov record NCT00000487?acronym=
All trials of Multiple risk factor interventions
Appears in following systematic reviews: