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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

DVT prophylaxis - anticoagulant - orthopedic surgery

DVT prophylaxis - antithrombotics - orthopedic surgery


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See also:

  • All DVT prophylaxis clinical trials
  • All clinical trials of antithrombotics
  • All clinical trials of Acenocoumarol
    		•  

    van Geloven study, 1977

    download pdf: Acenocoumarol | antithrombotics for DVT prophylaxis

    Treatments

    Studied treatment Acenocoumarol
    Control treatment UFH 4000 �x2

    Patients

    Patients THR

    Method and design

    Randomized effectives 11 / 11 (studied vs. control)
    Blinding double blind
    Follow-up duration NA


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    Symptomatic pulmonary embolism

    0 / 11
         0 / 11
         classic 1,00 [0,00;239,93]

    Deep vein thrombosis

    6 / 11
         5 / 11
         classic 1,20 [0,52;2,79]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    Deep vein thrombosis 6 / 11 (54,5%) 5 / 11 (45,5%) 1,20 [0,52;2,79]
    Symptomatic pulmonary embolism 0 / 11 (4,5%) 0 / 11 (4,5%) 1,00 [0,02;46,06]
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    Deep vein thrombosis 54,55% 45,45% 9,1%

    Meta-analysis of all similar trials:

    anticoagulant in DVT prophylaxis for orthopedic surgery

    antithrombotics in DVT prophylaxis for orthopedic surgery



    Reference(s)

    Trials register # NA
    • van Geloven F, Wittebol P, Sixma JJ. Comparison of postoperative coumarin, dextran 40 and subcutaneous heparin in the prevention of postoperative deep vein thrombosis.. Acta Med Scand 1977;202:367-72
      Pubmed | Hubmed | Fulltext

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