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See also:

  • All venous thrombosis clinical trials
    		•  

    Kakkar study, 2003

    Treatments

    Studied treatment LMWH, 115 IU/kg qd followed by Bemiparin 3,500 IU qd
    Control treatment A: UFH, 30/40,000IU qd; B: LMWH, 115 IU/kg qd followed by Warfarin target INR 2-3

    Patients

    Patients patients with objective diagnosis of DVT by Venography/compression ultrasonography
    Baseline characteristics
    objective DVT diagnosis Venography/CUS 
    objective PR diagnosis VPLS 
    cancer (%) NA 
    Outcome assessment blinded Yes 

    Method and design

    Randomized effectives 221 / 103 (studied vs. control)
    Blinding open
    Follow-up duration 3 mo
    Number of centre multicenter
    Primary endpoint none defined


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    VTE during active anticoagulant treatment

    5 / 221
         3 / 103
         classic 0,78 [0,19;3,19]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial
    Studied treat. Control treat.
    VTE during active anticoagulant treatment 5 / 221 (2,3%) 3 / 103 (2,9%) 0,78 [0,19;3,19]  
    The primary endpoint (if exists) appears in blod characters

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    VTE during active anticoagulant treatment 2,26% 2,91% -6,5‰


    Reference(s)

    Trials register # NA
    • Kakkar VV, Gebska M, Kadziola Z, Saba N, Carrasco P. Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis.. Thromb Haemost 2003;89:674-80
      Pubmed | Hubmed | Fulltext

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