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Systematic review and meta-analysis
This trial is included in the following systematic reviews and meta-analyses:
Related trials
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STRIDE-1 (Barst), 2004 - Sitaxsentan vs Placebo
BREATH-2 (Humbert), 2004 - Epoprostenol + Bosentan vs Epoprostenol + placebo
Sastry, 2004 - Sildenafil vs Placebo
Barst, 2003 - Beraprost vs Placebo
BREATHE-1 (Rubin), 2002 - Bosentan vs Placebo
Langleben, 2002 - Terbogrel vs Placebo
AIR (Olschewski), 2002 - Iloprost vs Placebo
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Simmoneau, 2002 - Treprostinil vs Placebo
Channick, 2001 - Bosentan vs Placebo
Badesch, 2000 - Epoprostenol vs control
See also:
Channick study, 2001 |
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 pdf :
Bosentan
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All mecanism for pulmonary hypertension
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Treatments
| Studied treatment |
Bosentan
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| Control treatment |
Placebo
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Patients
| Patients | patients with pulmonary hypertension (primary or associated with scleroderma) |
Method and design
| Randomized effectives | 21 / 11 (studied vs. control) |
| Blinding | double blind |
| Follow-up duration | 12 weeks |
| Primary endpoint | six-minute walk distance |
Results
n/N
n/N
All cause death
| Relative risks | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Endpoint | Events (%) | Relative Risk | 95% CI | Endpoint definition in the trial |
Ref | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Studied treat. | Control treat. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| All cause death | 0 / 21 (2,4%) | 0 / 11 (4,5%) | 0,52 | [0,01;24,65] | 10044 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The primary endpoint (if exists) appears in blod characters | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Reference(s) used for data extraction:
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| Absolute risk reduction | ||||
| Endpoint | Events rate | Absolute risk reduction (ARR) |
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|---|---|---|---|---|
| Studied treat. | Control treat. | |||
Meta-analysis of all similar trials:
All mecanism in pulmonary hypertension for all patients
Reference(s)
| Trials register # | NA |
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Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, Badesch DB, Roux S, Rainisio M, Bodin F, Rubin LJ.
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Lancet 2001;358:1119-23
- 10.1016/S0140-6736(01)06250-X
Pubmed
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Hubmed
| Fulltext
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