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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

pulmonary hypertension - All mecanism - all patients


Related trials

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STRIDE-2 (Barst), 2006 - Sitaxsentan vs Placebo

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SERAPH (Wilkins), 2005 - Bosentan vs Sildenafil

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BREATH-2 (Humbert), 2004 - Epoprostenol + Bosentan vs Epoprostenol + placebo

Sastry, 2004 - Sildenafil vs Placebo

Barst, 2003 - Beraprost vs Placebo

BREATHE-1 (Rubin), 2002 - Bosentan vs Placebo

Langleben, 2002 - Terbogrel vs Placebo

AIR (Olschewski), 2002 - Iloprost vs Placebo

ALPHABET (Galie), 2002 - Beraprost vs Placebo

Simmoneau, 2002 - Treprostinil vs Placebo

Channick, 2001 - Bosentan vs Placebo

Badesch, 2000 - Epoprostenol vs control

Barst, 1996 - Epoprostenol vs control

Rubin, 1990 - Epoprostenol vs control



See also:

  • All pulmonary hypertension clinical trials
  • All clinical trials of All mecanism
  • All clinical trials of Beraprost
    		•  

    Barst study, 2003

    Facebook    pdf : Beraprost - All mecanism for pulmonary hypertension

    Treatments

    Studied treatment Beraprost
    Control treatment Placebo

    Patients

    Method and design

    Randomized effectives 60 / 56 (studied vs. control)
    Follow-up duration 36 weeks
    Primary endpoint VO2 max


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    All cause death

    1 / 60
         2 / 56
         classic 0,47 [0,04;5,01]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    All cause death 1 / 60 (1,7%) 2 / 56 (3,6%) 0,47 [0,04;5,01]   10044 
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:
  • 10044: Gali� N, Manes A, Negro L, Palazzini M, Bacchi Reggiani ML, Branzi AEur Heart J 2009;:

    • Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.
    All cause death 1,67% 3,57% -19,0‰

    Meta-analysis of all similar trials:

    All mecanism in pulmonary hypertension for all patients



    Reference(s)

    Trials register # NA
    • Barst RJ, McGoon M, Mc Laughlin VV, Tapson V, Rich S, Rubin L, Wasserman K,. . J Am Coll Cardiol 2003;41:2125
      Pubmed | Hubmed | Fulltext

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