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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

hypertension - strategy - non diabetic patients

hypertension - strategy - all type of patients


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HOT, 1994 - more intensive blood pressure lowering strategie vs less intensive blood pressure lowering strategie

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See also:

  • All hypertension clinical trials
  • All clinical trials of strategy
  • All clinical trials of more intensive blood pressure lowering strategie
  •  

    MDRD study, 1994

    Facebook    pdf : more intensive blood pressure lowering strategie - strategy for hypertension

    Treatments

    Studied treatment low target blood pressure (mean arterial pressure < 92 mm Hg)
    Control treatment usual target blood pressure (mean arterial pressure < 107 mm Hg)

    Patients

    Patients patients with predominantly nondiabetic kidney disease and a glomerular filtration rate of 13 to 55 mL/min per 1.73 m2
    Baseline characteristics
    Number of antihypertensive drugs 1.91/1.5 

    Method and design

    Randomized effectives 840
    Blinding open
    Follow-up duration 2.2 y
    Number of centre 15


    Results

    No results available for this trial - no clinical endpoint reported

    Meta-analysis of all similar trials:

    strategy in hypertension for non diabetic patients

    strategy in hypertension for all type of patients



    Reference(s)

    Trials register # NA
    • Klahr S, Levey AS, Beck GJ, Caggiula AW, Hunsicker L, Kusek JW, Striker G. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group.. N Engl J Med 1994;330:877-84
      Pubmed | Hubmed | Fulltext
    • Lazarus JM, Bourgoignie JJ, Buckalew VM, Greene T, Levey AS, Milas NC, Paranandi L, Peterson JC, Porush JG, Rauch S, Soucie JM, Stollar C. Achievement and safety of a low blood pressure goal in chronic renal disease. The Modification of Diet in Renal Disease Study Group.. Hypertension 1997;29:641-50
      Pubmed | Hubmed | Fulltext
    • Peterson JC, Adler S, Burkart JM, Greene T, Hebert LA, Hunsicker LG, King AJ, Klahr S, Massry SG, Seifter JL. Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study.. Ann Intern Med 1995;123:754-62
      Pubmed | Hubmed | Fulltext
    • Sarnak MJ, Greene T, Wang X, Beck G, Kusek JW, Collins AJ, Levey AS. The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study.. Ann Intern Med 2005;142:342-51
      Pubmed | Hubmed | Fulltext

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