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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

diabetes - anti hypertensive agent - type1 and 2 diabetic patients with hypertension

hypertension - anti hypertensive agent - diabetic patients


Related trials

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See also:

  • All diabetes clinical trials
  • All hypertension clinical trials
  • All clinical trials of anti hypertensive agent
  • All clinical trials of amlodipine
    		•  

    ALLHAT (amlodipine vs chlor, diabetic subgroup) study, 2002

    Facebook    pdf : amlodipine - anti hypertensive agent for hypertension

    Treatments

    Studied treatment amlodipine
    Control treatment chlorthalidone

    Patients

    Patients diabetic (subgroup) participants aged 55 years or older with hypertension

    Method and design

    Randomized effectives 3323 / 5528 (studied vs. control)
    Design Parallel groups
    Blinding double-blind
    Primary endpoint fatal CHD or nonfatal MI


    Results

    Endpoint Studied treat.
    n/N     Control treat.
    n/N     Graph RR [95% CI]

    cardiovascular event (fatal and non fatal)

    NA / 3323
         NA / 5528
         1,06 [0,98;1,15]

    Cardiovascular death

    NA / 3323
         NA / 5528

    All cause death

    NA / 3323
         NA / 5528
         0,96 [0,87;1,06]

    stroke (fatal and non fatal)

    NA / 3323
         NA / 5528
         0,90 [0,75;1,08]

    myocardial infarction (fatal and non fatal)

    NA / 3323
         NA / 5528
         0,99 [0,87;1,13]     0 2 1.0

    Relative risks
    Endpoint Events (%) Relative Risk 95% CI Endpoint definition
    in the trial    		 Ref
    Studied treat. Control treat.
    The primary endpoint (if exists) appears in blod characters
    Reference(s) used for data extraction:

    Endpoint studied treat. control treat. mean diff

    Absolute risk reduction
    Endpoint Events rate Absolute risk
    reduction (ARR)
    Studied treat. Control treat.

    Meta-analysis of all similar trials:

    anti hypertensive agent in diabetes for type1 and 2 diabetic patients with hypertension

    anti hypertensive agent in hypertension for diabetic patients



    Reference(s)

    Trials register # NA
    • . Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).. JAMA 2002;288:2981-97
      Pubmed | Hubmed | Fulltext

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