Related trials
ROADMAP, 2010 - olmesartan vs placebo
ADVANCE, 2007 - perindopril and indapamide vs placebo
LIFE (diabetic subgroup), 2002 - losartan vs atenolol
ALLHAT (lisi vs chlor, diabetic subgroup), 2002 - lisinopril vs chlorthalidone
IDNT irbesartan, 2001 - Irbesartan vs placebo
IPDM, 2001 - irbesartan vs placebo
RENAAL, 2001 - losartan vs placebo
IDNT (irbesartan vs amlodipine), 2001 - Irbesartan vs amlodipine
STOP-2 ACEI (diabetic subgroup), 2000 - ACE inhibitor vs diuretic or beta-blocker
STOP-2 (ACEI vs CCB) (diabetic subgroup), 2000 - ACE inhibitor vs CCB
HOPE (diabetic subgroup), 2000 - ACE inhibitor vs placebo
CAPP (diabetic subgroup), 1999 - captopril vs diuretic or beta-blocker
UKPDS 38, 1998 - captopril or atenolol vs control
UKPDS 39, 1998 - captopril vs atenolol
ORIENT, - olmesartan vs placebo
See also:
All diabetes clinical trials
All clinical trials of anti hypertensive agent
All clinical trials of perindopril and indapamide
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Treatments
Studied treatment |
fixed combination of perindopril and indapamide
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Control treatment |
placebo
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Concomittant treatment |
current therapy |
Patients
Patients |
patients with type 2 diabetes irrespective of initial blood pressure levels or the use of other blood pressure lowering drugs |
Method and design
Randomized effectives |
NA / NA (studied vs. control) |
Primary endpoint |
composites of major macrovascular and microvascular events |
Results
No results available for this trial
- no clinical endpoint reported
Meta-analysis of all similar trials:
angiotensin renin system blockade in diabetes for all type of patients
angiotensin-receptor blockers in diabetes for all type of patients
anti hypertensive agent in diabetes for patients with or without hypertension
Reference(s)
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Rationale and design of the ADVANCE study: a randomised trial of blood pressure lowering and intensive glucose control in high-risk individuals with type 2 diabetes mellitus. Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation..
J Hypertens Suppl 2001 Nov;19:S21-8
Pubmed
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Hubmed
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Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B.
Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial..
Lancet 2007 Sep 8;370:829-40
Pubmed
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Hubmed
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