ADVANCE trial

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Systematic review and meta-analysis

This trial is included in the following systematic reviews and meta-analyses:

Related trials

ROADMAP, 2010 - olmesartan vs placebo

Treatments

Studied treatment	fixed combination of perindopril and indapamide
Control treatment	placebo
Concomittant treatment	current therapy

patients with type 2 diabetes irrespective of initial blood pressure levels or the use of other blood pressure lowering drugs

Randomized effectives	NA / NA (studied vs. control)
Primary endpoint	composites of major macrovascular and microvascular events

No results available for this trial - no clinical endpoint reported

Meta-analysis of all similar trials:

Trials register #	NCT00145925
Study web site link	,

. Rationale and design of the ADVANCE study: a randomised trial of blood pressure lowering and intensive glucose control in high-risk individuals with type 2 diabetes mellitus. Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation.. J Hypertens Suppl 2001 Nov;19:S21-8
Pubmed | Hubmed | Fulltext

Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial.. Lancet 2007 Sep 8;370:829-40
Pubmed | Hubmed | Fulltext