See also:

Patti et al. study, 2006	TRC7246
	download pdf: preoperative atorvastatin | cholesterol lowering intervention for CABG surgery

Treatments

Studied treatment	preoperative atorvastatin 40 mg/d, starting 7 days before operation
Control treatment	placebo

Patients

Patients

patients undergoing elective cardiac surgery with cardiopulmonary bypass, without previous statin treatment or history of AF

Method and design

Randomized effectives	101 / 99 (studied vs. control)
Blinding	double blind
Follow-up duration	30 days

Results

Endpoint Studied treat.
n/N Control treat.
n/N Graph RR [95% CI]

atrial fibrillation

35 / 101
56 / 99
0,61 [0,45;0,84]

myocardial infarction (fatal and non fatal)

3 / 101
3 / 99
classic 0,98 [0,20;4,74]

All cause death

2 / 101
2 / 99
classic 0,98 [0,14;6,82] 0 2 1.0

Relative risks
Endpoint	Events (%)		Relative Risk	95% CI	Endpoint definition in the trial	Ref
	Studied treat.	Control treat.
atrial fibrillation	35 / 101 (34,7%)	56 / 99 (56,6%)	0,61	[0,45;0,84]
myocardial infarction (fatal and non fatal)	3 / 101 (3,0%)	3 / 99 (3,0%)	0,98	[0,20;4,74]
All cause death	2 / 101 (2,0%)	2 / 99 (2,0%)	0,98	[0,14;6,82]
The primary endpoint (if exists) appears in blod characters
Reference(s) used for data extraction: 0:

Endpoint	studied treat.	control treat.	mean diff

Absolute risk reduction (for a follow-up of 30 days)
Endpoint	Events rate		Absolute risk reduction (ARR)
	Studied treat.	Control treat.
atrial fibrillation	34,65%	56,57%	-21,91%
myocardial infarction (fatal and non fatal)	2,97%	3,03%	-0,06%
All cause death	1,98%	2,02%	-0,04%

Meta-analysis of all similar trials:

cholesterol lowering intervention in CABG surgery for preoperative statins

Reference(s)

TrialResults-center ID	TRC7246
Trials register #	NA

• Patti G, Chello M, Candura D, Pasceri V, D'Ambrosio A, Covino E, Di Sciascio G. Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) study.. Circulation 2006;114:1455-61
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